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First published online on November 29, 2007
This version published online on May 12, 2008
Endocrine Reviews, doi:10.1210/er.2007-0033
Endocrine Reviews, doi:10.1210/er.2007-0033
Endocrine Reviews 0 (2008): 200700332-
Copyright © 2008 by The Endocrine Society
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Submitted on September 19, 2007
Accepted on November 13, 2007

Cytokines and {beta}-Cell Biology: from Concept to Clinical Translation

Marc Y. Donath, Joachim Størling, Lukas A. Berchtold, Nils Billestrup, and Thomas Mandrup-Poulsen*

The Clinic for Endocrinology and Diabetes (M.Y.D.), University Hospital Zurich, CH-8091 Zurich, Switzerland; Department for Translational Diabetology (J.S., L.A.B., N.B., T.M.-P.), Steno Diabetes Center, DK-2820 Gentofte, Denmark; and Core Unit for Medical Research Methodology (T.M.-P.), Institute of Biomedicine, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark

* To whom correspondence should be addressed. E-mail: tmpo{at}steno.dk.

The tale of cytokines and the {beta}-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate the accumulating compelling preclinical data into clinical trials. The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation.




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