| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Departmento de Inmunología y Oncología, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, E-28049 Madrid, Spain
* To whom correspondence should be addressed. E-mail: jlpompa{at}cnb.uam.es.
Notch is an evolutionarily conserved local cell signaling mechanism that participates in a variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis, adhesion, epithelial-mesenchymal transition, migration, and angiogenesis. These processes can be subverted in Notch-mediated pathological situations. In the first part of this review, we will discuss the role of Notch in vertebrate central nervous system development, somitogenesis, cardiovascular and endocrine development, with attention to the mechanisms by which Notch regulates cell fate specification and patterning in these tissues. In the second part, we will review the molecular aspects of Notch-mediated neoplasias, where Notch can act as an oncogene or as a tumor suppressor. From all these studies, it becomes evident that the outcome of Notch signaling is strictly context-dependent and differences in the strength, timing, cell type, and context of the signal may affect the final outcome. It is essential to understand how Notch integrates inputs from other signaling pathways and how specificity is achieved, because this knowledge may be relevant for future therapeutic applications.
This article has been cited by other articles:
 |
|
 |
|
  K.-W. Hsu, R.-H. Hsieh, Y.-H. W. Lee, C.-H. Chao, K.-J. Wu, M.-J. Tseng, and T.-S. Yeh The Activated Notch1 Receptor Cooperates with {alpha}-Enolase and MBP-1 in Modulating c-myc Activity Mol. Cell. Biol., August 1, 2008; 28(15): 4829 - 4842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cordle, C. RedfieldZ, M. Stacey, P. A. van der Merwe, A. C. Willis, B. R. Champion, S. Hambleton, and P. A. Handford Localization of the Delta-like-1-binding Site in Human Notch-1 and Its Modulation by Calcium Affinity J. Biol. Chem., April 25, 2008; 283(17): 11785 - 11793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bai, R. Kopan, W. Zou, M. J. Hilton, C.-t. Ong, F. Long, F. P. Ross, and S. L. Teitelbaum NOTCH1 Regulates Osteoclastogenesis Directly in Osteoclast Precursors and Indirectly via Osteoblast Lineage Cells J. Biol. Chem., March 7, 2008; 283(10): 6509 - 6518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Ning, D. Y. Greenblatt, M. Kunnimalaiyaan, and H. Chen Suberoyl Bis-Hydroxamic Acid Activates Notch-1 Signaling and Induces Apoptosis in Medullary Thyroid Carcinoma Cells Oncologist, February 1, 2008; 13(2): 98 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kennard, H. Liu, and B. Lilly Transforming Growth Factor- (TGF- 1) Down-regulates Notch3 in Fibroblasts to Promote Smooth Muscle Gene Expression J. Biol. Chem., January 18, 2008; 283(3): 1324 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Karsan Notch and Integrin Affinity: A Sticky Situation Sci. Signal., January 15, 2008; 1(2): pe2 - pe2. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
