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First published online on June 20, 2006
Endocrine Reviews, doi:10.1210/er.2006-0021
Endocrine Reviews, doi:10.1210/er.2006-0021
Endocrine Reviews 0 (2006): 200600211-
Copyright © 2006 by The Endocrine Society
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Expanding the Scales: The Multiple Roles of MCH in Regulating Energy Balance and Other Biological Functions

Pavlos Pissios, Richard L. Bradley, and Eleftheria Maratos-Flier*

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215

* To whom correspondence should be addressed. E-mail: emaratos{at}bidmc.harvard.edu.

Melanin-concentrating hormone (MCH) is a cyclic peptide originally identified as a 17-amino acid circulating hormone in teleost fish, where it is secreted by the pituitary, in response to stress and environmental stimuli. In fish, MCH lightens skin color by stimulating aggregation of melanosomes, pigment-containing granules in melanophores, cells of neuroectodermal origin found in fish scales. Although the peptide structure between fish and mammals is highly conserved, in mammals, MCH has no demonstrable effects on pigmentation; instead, based on a series of pharmacological and genetic experiments, MCH has emerged as a critical hypothalamic regulator of energy homeostasis, having effects on both feeding behavior and energy expenditure.
Key words: melanin-concentrating hormone • energy balance • MCH receptor




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