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Endocrine Research Unit (J.D.V.), Department of Internal Medicine, Mayo Medical School, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905; Department of Pediatrics (J.N.R.), State University of New York at Buffalo, Buffalo, New York 14214-3000; Pediatric Endocrinology (E.J.R.), National Children's Hospital, San Jose 1000, Costa Rica; and Division of Endocrinology and Metabolism (C.Y.B.), Department of Internal Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112-2699
* To whom correspondence should be addressed. E-mail: Veldhuis.Johannes{at}mayo.edu.
Integrative neuroendocrine control of the gonadotropic and somatotropic axes in childhood, puberty, and young adulthood proceeds via multiple convergent and divergent pathways in the human and experimental animal. Emerging ensemble concepts are required to embody independent, parallel, and interacting mechanisms that subserve physiological adaptations and pathological disruption of reproduction and growth. Significant advances in systems biology will be needed to address these challenges.
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