help button home button Endocrine Society Endocrine Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
First published online on November 23, 2004
Endocrine Reviews, doi:10.1210/er.2002-0017
A more recent version of this article appeared on April 1, 2005
This Article
Right arrow Author Manuscript (PDF)
Right arrow All Versions of this Article:
26/2/203    most recent
Final Manuscript
Author Manuscript
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Smith, R. G.
Right arrow Articles by Sun, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith, R. G.
Right arrow Articles by Sun, Y.

Molecular Endocrinology and Physiology of the Aging Central Nervous System

Roy G. Smith Ph.D,*, Lorena Betancourt M.D,, and Yuxiang Sun Ph.D

Huffington Center on Aging and Department of Molecular and Cellular Biology and Department of Medicine, Baylor College of Medicine, Houston, Texas

* To whom correspondence should be addressed. E-mail: rsmith{at}bcm.tmc.edu.

Aging is associated with a progressive decline in physical and cognitive functions. The impact of age-dependent endocrine changes regulated by the central nervous system (CNS) on the dynamics of neuronal behavior, neurodegeneration, cognition, biological rhythms, sexual behavior, and metabolism are reviewed. We also briefly review how functional deficits associated with increases in glucocorticoids and cytokines and declining production of sex steroids, GH and insulin-like growth factor are likely exacerbated by age-dependent molecular misreading and alterations in components of signal transduction pathways and transcription factors.
Key words: aging • brain • cognition • neuroendocrinology • neurogenesis • complexity • GnRH • estradiol • testosterone • dopamine • GHS-R • growth hormone • IGF-1 • GHRH • GnRH • LH • somatostatin • galanin • POMC • CRH




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
X. Shi, F. A. Schaller, N. Tierney, P. Chanthavong, S. Chen, P. B. Raven, and M. L. Smith
Physically Active Lifestyle Enhances Vagal-Cardiac Function but Not Central Autonomic Neural Interaction in Elderly Humans
Experimental Biology and Medicine, February 1, 2008; 233(2): 209 - 218.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Almeida, L. Han, M. Martin-Millan, L. I. Plotkin, S. A. Stewart, P. K. Roberson, S. Kousteni, C. A. O'Brien, T. Bellido, A. M. Parfitt, et al.
Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids
J. Biol. Chem., September 14, 2007; 282(37): 27285 - 27297.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
M. G. S. Frutos, L. Cacicedo, C. F. Mendez, D. Vicent, M. Gonzalez, and F. Sanchez-Franco
Pituitary Alterations Involved in the Decline of Growth Hormone Gene Expression in the Pituitary of Aging Rats
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2007; 62(6): 585 - 597.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. Schumacher, R. Guennoun, A. Ghoumari, C. Massaad, F. Robert, M. El-Etr, Y. Akwa, K. Rajkowski, and E.-E. Baulieu
Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System
Endocr. Rev., June 1, 2007; 28(4): 387 - 439.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
L. Fontana and S. Klein
Aging, Adiposity, and Calorie Restriction
JAMA, March 7, 2007; 297(9): 986 - 994.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Bondanelli, M. R. Ambrosio, A. Onofri, A. Bergonzoni, S. Lavezzi, M. C. Zatelli, D. Valle, N. Basaglia, and E. C. degli Uberti
Predictive Value of Circulating Insulin-Like Growth Factor I Levels in Ischemic Stroke Outcome
J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3928 - 3934.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2004 by The Endocrine Society