This Article Full Text Full Text (PDF) All Versions of this Article: 26/7/916    most recent Final Manuscript Author Manuscript Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Russo, V. C. Articles by Werther, G. A. Search for Related Content PubMed PubMed Citation Articles by Russo, V. C. Articles by Werther, G. A.

The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain

Murdoch Children’s Research Institute (V.C.R., G.A.W.), Centre for Hormone Research, Royal Children’s Hospital, Parkville 3052, Victoria, Australia; Department of Paediatrics (V.C.R., G.A.W.), University of Melbourne, Parkville 3052, Victoria, Australia; Liggins Institute and National Research Centre for Growth and Development (P.D.G.), University of Auckland, Auckland 1020, New Zealand; and Department of Neurology (E.L.F.), University of Michigan, Ann Arbor, Michigan 48109

Correspondence: Address all correspondence and requests for reprints to: Vincenzo C. Russo, Ph.D., Centre for Hormone Research, Murdoch Children’s Research Institute, Royal Children’s Hospital, Flemington Road, Parkville, Victoria 3052, Australia. E-mail: vince.russo{at}mcri.edu.au

In recent years, much interest has been devoted to defining the role of the IGF system in the nervous system. The ubiquitous IGFs, their cell membrane receptors, and their carrier binding proteins, the IGFBPs, are expressed early in the development of the nervous system and are therefore considered to play a key role in these processes. In vitro studies have demonstrated that the IGF system promotes differentiation and proliferation and sustains survival, preventing apoptosis of neuronal and brain derived cells. Furthermore, studies of transgenic mice overexpressing components of the IGF system or mice with disruptions of the same genes have clearly shown that the IGF system plays a key role in vivo.

This article has been cited by other articles:

				A. Peri and M. Serio Neuroprotective effects of the Alzheimer's disease-related gene seladin-1 J. Mol. Endocrinol., November 1, 2008; 41(5): 251 - 261. [Abstract] [Full Text] [PDF]

				M. M. Chitnis, J. S.P. Yuen, A. S. Protheroe, M. Pollak, and V. M. Macaulay The Type 1 Insulin-Like Growth Factor Receptor Pathway Clin. Cancer Res., October 15, 2008; 14(20): 6364 - 6370. [Abstract] [Full Text] [PDF]

				S Giannini, S Benvenuti, P Luciani, C Manuelli, I Cellai, C Deledda, A Pezzatini, G B Vannelli, E Maneschi, C M Rotella, et al. Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system: the involvement of the neuroprotective factor DHCR24 (Seladin-1) J. Endocrinol., September 1, 2008; 198(3): 523 - 532. [Abstract] [Full Text] [PDF]

				S. Lonn, N. Rothman, W. R. Shapiro, H. A. Fine, R. G. Selker, P. M. Black, J. S. Loeffler, A. A. Hutchinson, and P. D. Inskip Genetic variation in insulin-like growth factors and brain tumor risk Neuro-oncol, August 1, 2008; 10(4): 553 - 559. [Abstract] [Full Text] [PDF]

				M. Ishii and N. Maeda Spatiotemporal expression of chondroitin sulfate sulfotransferases in the postnatal developing mouse cerebellum Glycobiology, August 1, 2008; 18(8): 602 - 614. [Abstract] [Full Text] [PDF]

				K. Raikkonen, A.-K. Pesonen, K. Heinonen, E. Kajantie, P. Hovi, A.-L. Jarvenpaa, J. G. Eriksson, and S. Andersson Depression in Young Adults With Very Low Birth Weight: The Helsinki Study of Very Low-Birth-Weight Adults Arch Gen Psychiatry, March 1, 2008; 65(3): 290 - 296. [Abstract] [Full Text] [PDF]

				R. L. Chen, N. A. Kassem, M. Sadeghi, and J. E. Preston Insulin-Like Growth Factor-II Uptake Into Choroid Plexus and Brain of Young and Old Sheep J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2008; 63(2): 141 - 148. [Abstract] [Full Text] [PDF]

				M J E Walenkamp and J M Wit Genetic disorders in the GH IGF-I axis in mouse and man Eur. J. Endocrinol., August 1, 2007; 157(suppl_1): S15 - S26. [Abstract] [Full Text] [PDF]

				H. Chung, S. Seo, M. Moon, and S. Park IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4 J. Endocrinol., July 1, 2007; 194(1): 77 - 85. [Abstract] [Full Text] [PDF]

				S. Lonn, P. D. Inskip, M. N. Pollak, S. J. Weinstein, J. Virtamo, and D. Albanes Glioma Risk in Relation to Serum Levels of Insulin-Like Growth Factors Cancer Epidemiol. Biomarkers Prev., April 1, 2007; 16(4): 844 - 846. [Abstract] [Full Text] [PDF]

				P. Klover and L. Hennighausen Postnatal Body Growth Is Dependent on the Transcription Factors Signal Transducers and Activators of Transcription 5a/b in Muscle: A Role for Autocrine/Paracrine Insulin-Like Growth Factor I Endocrinology, April 1, 2007; 148(4): 1489 - 1497. [Abstract] [Full Text] [PDF]

				L. Y. Sun and A. J. D'Ercole Insulin-Like Growth Factor-I Stimulates Histone H3 and H4 Acetylation in the Brain in Vivo Endocrinology, November 1, 2006; 147(11): 5480 - 5490. [Abstract] [Full Text] [PDF]

				N. Wilczak, J. W. Elting, D. Chesik, I. P. Kema, and J. De Keyser Intravenous Tissue Plasminogen Activator in Patients With Stroke Increases the Bioavailability of Insulin-Like Growth Factor-1 Stroke, September 1, 2006; 37(9): 2368 - 2371. [Abstract] [Full Text] [PDF]