| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Molecular and Medical Pharmacology (D.J.M.), University of California Los Angeles School of Medicine, Los Angeles, California 90095; The Prostate Centre at Vancouver General Hospital (D.J.M., S.D., C.C.N.), Vancouver, British Columbia, Canada V6H 3Z6; and University of Southern California/Norris Cancer Center, Keck School of Medicine (G.A.C.), Los Angeles, California 90033
Correspondence: Address all correspondence and requests for reprints to: David J. Mulholland, Department of Molecular and Medical Pharmacology, 650 Charles E. Young Drive, Center for Health Sciences 23-234, University of California Los Angeles School of Medicine, Los Angeles, California 90095. E-mail: dmulholland{at}mednet.ucla.edu
The cross-regulation of Wnt/ß-catenin/Tcf ligands, kinases, and transcription factors with members of the nuclear receptor (NR) family has emerged as a clinically and developmentally important area of endocrine cell biology. Interactions between these signaling pathways result in a diverse array of cellular effects including altered cellular adhesion, tissue morphogenesis, and oncogenesis. Analyses of NR interactions with canonical Wnt signaling reveal two broad themes: Wnt/ß-catenin modulation of NRs (theme I), and ligand-dependent NR inhibition of the Wnt/ß-catenin/Tcf cascade (theme II). ß-Catenin, a promiscuous Wnt signaling member, has been studied intensively in relation to the androgen receptor (AR). ß-Catenin acts as a coactivator of AR transcription and is also involved in cotrafficking, increasing cell proliferation, and prostate pathogenesis. T cell factor, a transcriptional mediator of ß-catenin and AR, engages in a dynamic reciprocity of nuclear ß-catenin, p300/CREB binding protein, and transcriptional initiation factor 2/GC receptor-interaction protein, thereby facilitating hormone-dependent coactivation and transrepression. ß-Catenin responds in an equally dynamic manner with other NRs, including the retinoic acid (RA) receptor (RAR), vitamin D receptor (VDR), glucocorticoid receptor (GR), progesterone receptor, thyroid receptor (TR), estrogen receptor (ER), and peroxisome proliferator-activated receptor (PPAR). The NR ligands, vitamin D3, trans/cis RA, glucocorticoids, and thiazolidines, induce dramatic changes in the physiology of cells harboring high Wnt/ß-catenin/Tcf activity. Wnt signaling regulates, directly or indirectly, developmental processes such as ductal branching and adipogenesis, two processes dependent on NR function. ß-Catenin has been intensively studied in colorectal cancer; however, it is now evident that ß-catenin may be important in cancers of the breast, prostate, and thyroid. This review will focus on the cross-regulation of AR and Wnt/ß-catenin/Tcf but will also consider the dynamic manner in which RAR/RXR, GR, TR, VDR, ER, and PPAR modulate canonical Wnt signaling. Although many commonalities exist by which NRs interact with the Wnt/ß-catenin signaling pathway, striking cell line and tissue-specific differences require deciphering and application to endocrine pathology.
This article has been cited by other articles:
 |
|
 |
|
  L. Jin, Y. Li, C.-J. Chen, M. A. Sherman, K. Le, and J. E. Shively Direct Interaction of Tumor Suppressor CEACAM1 with Beta Catenin: Identification of Key Residues in the Long Cytoplasmic Domain Experimental Biology and Medicine, July 1, 2008; 233(7): 849 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ray, F. Xu, H. Wang, and S. K. Das Cooperative Control via Lymphoid Enhancer Factor 1/T Cell Factor 3 and Estrogen Receptor-{alpha} for Uterine Gene Regulation by Estrogen Mol. Endocrinol., May 1, 2008; 22(5): 1125 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Guo, J. Flanagan, R. Jasuja, J. Kirkland, L. Jiang, and S. Bhasin The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/{beta}-Catenin Signaling Pathways J. Biol. Chem., April 4, 2008; 283(14): 9136 - 9145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Costa, D Foti, F Paonessa, E Chiefari, L Palaia, G Brunetti, E Gulletta, A Fusco, and A Brunetti The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-{gamma} (PPAR{gamma}) and thiazolidinedione-PPAR{gamma} agonists Endocr. Relat. Cancer, March 1, 2008; 15(1): 325 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wohrle, B. Wallmen, and A. Hecht Differential Control of Wnt Target Genes Involves Epigenetic Mechanisms and Selective Promoter Occupancy by T-Cell Factors Mol. Cell. Biol., December 1, 2007; 27(23): 8164 - 8177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kitagawa, W. J. Ray, H. Glantschnig, P. V. Nantermet, Y. Yu, C.-T. Leu, S.-i. Harada, S. Kato, and L. P. Freedman A Regulatory Circuit Mediating Convergence between Nurr1 Transcriptional Regulation and Wnt Signaling Mol. Cell. Biol., November 1, 2007; 27(21): 7486 - 7496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. T. Raitakari, T. Ronnemaa, R. Huupponen, L. Viikari, M. Fan, J. Marniemi, N. Hutri-Kahonen, J. S.A. Viikari, and T. Lehtimakimd Variation of the Transcription Factor 7-Like 2 (TCF7L2) Gene Predicts Impaired Fasting Glucose in Healthy Young Adults: The Cardiovascular Risk in Young Finns Study Diabetes Care, September 1, 2007; 30(9): 2299 - 2301. [Full Text] [PDF]
|
|
|
|
|
|
V. J. Armstrong, M. Muzylak, A. Sunters, G. Zaman, L. K. Saxon, J. S. Price, and L. E. Lanyon Wnt/beta-Catenin Signaling Is a Component of Osteoblastic Bone Cell Early Responses to Load-bearing and Requires Estrogen Receptor {alpha} J. Biol. Chem., July 13, 2007; 282(28): 20715 - 20727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nilsson, K. Dahlman-Wright, C. Karelmo, J.-A. Gustafsson, and K. R. Steffensen Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter Nucleic Acids Res., July 10, 2007; (2007) gkm492v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cianferotti, M. Cox, K. Skorija, and M. B. Demay Vitamin D receptor is essential for normal keratinocyte stem cell function PNAS, May 29, 2007; 104(22): 9428 - 9433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Lin, S. Reierstad, C.-C. Huang, and S. E. Bulun Novel Estrogen Receptor-{alpha} Binding Sites and Estradiol Target Genes Identified by Chromatin Immunoprecipitation Cloning in Breast Cancer Cancer Res., May 15, 2007; 67(10): 5017 - 5024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Zapata-Gonzalez, F. Rueda, J. Petriz, P. Domingo, F. Villarroya, A. de Madariaga, and J. C. Domingo 9-cis-Retinoic Acid (9cRA), a Retinoid X Receptor (RXR) Ligand, Exerts Immunosuppressive Effects on Dendritic Cells by RXR-Dependent Activation: Inhibition of Peroxisome Proliferator-Activated Receptor {gamma} Blocks Some of the 9cRA Activities, and Precludes Them to Mature Phenotype Development J. Immunol., May 15, 2007; 178(10): 6130 - 6139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Duque As a Matter of Fat: New Perspectives on the Understanding of Age-Related Bone Loss IBMS BoneKEy, April 1, 2007; 4(4): 129 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Chen, C. K. Yang, M. Xia, C.-Y. Ou, and M. R. Stallcup Role of GAC63 in transcriptional activation mediated by {beta}-catenin Nucleic Acids Res., March 19, 2007; 35(6): 2084 - 2092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. I. zur Nieden, F. D. Price, L. A. Davis, R. E. Everitt, and D. E. Rancourt Gene Profiling on Mixed Embryonic Stem Cell Populations Reveals a Biphasic Role for {beta}-Catenin in Osteogenic Differentiation Mol. Endocrinol., March 1, 2007; 21(3): 674 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kousteni, M. Almeida, L. Han, T. Bellido, R. L. Jilka, and S. C. Manolagas Induction of Osteoblast Differentiation by Selective Activation of Kinase-Mediated Actions of the Estrogen Receptor Mol. Cell. Biol., February 15, 2007; 27(4): 1516 - 1530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Clee and A. D. Attie The Genetic Landscape of Type 2 Diabetes in Mice Endocr. Rev., February 1, 2007; 28(1): 48 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lecka-Czernik, C. Ackert-Bicknell, M. L. Adamo, V. Marmolejos, G. A. Churchill, K. R. Shockley, I. R. Reid, A. Grey, and C. J. Rosen Activation of Peroxisome Proliferator-Activated Receptor {gamma} (PPAR{gamma}) by Rosiglitazone Suppresses Components of the Insulin-Like Growth Factor Regulatory System in Vitro and in Vivo Endocrinology, February 1, 2007; 148(2): 903 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rider, K. Isuzugawa, M. Twarog, S. Jones, B. Cameron, K. Imakawa, and J. Fang Progesterone initiates Wnt-{beta}-catenin signaling but estradiol is required for nuclear activation and synchronous proliferation of rat uterine stromal cells J. Endocrinol., December 1, 2006; 191(3): 537 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Yang, R. Kurotani, A. Yamada, S. Kimura, and F. J. Gonzalez Peroxisome Proliferator-Activated Receptor {alpha} Activation during Pregnancy Severely Impairs Mammary Lobuloalveolar Development in Mice Endocrinology, October 1, 2006; 147(10): 4772 - 4780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zhang, L. Qi, D. J. Hunter, J. B. Meigs, J. E. Manson, R. M. van Dam, and F. B. Hu Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene and the Risk of Type 2 Diabetes in Large Cohorts of U.S. Women and Men Diabetes, September 1, 2006; 55(9): 2645 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, H. Wang, Y. Zuo, and S. R. Farmer Functional Interaction between Peroxisome Proliferator-Activated Receptor {gamma} and {beta}-Catenin Mol. Cell. Biol., August 1, 2006; 26(15): 5827 - 5837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Poutanen Toward understanding the endocrine regulation of gonadal somatic cells. Endocrinology, August 1, 2006; 147(8): 3662 - 3665. [Full Text] [PDF]
|
|
|
|
|
|
S. Takayama, I. Rogatsky, L. E. Schwarcz, and B. D. Darimont The Glucocorticoid Receptor Represses Cyclin D1 by Targeting the Tcf-beta-Catenin Complex J. Biol. Chem., June 30, 2006; 281(26): 17856 - 17863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Almeida, L. Han, C. A. O'Brien, S. Kousteni, and S. C. Manolagas Classical Genotropic Versus Kinase-Initiated Regulation of Gene Transcription by the Estrogen Receptor {alpha} Endocrinology, April 1, 2006; 147(4): 1986 - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Mhyre, R. A. Shapiro, and D. M. Dorsa Estradiol Reduces Nonclassical Transcription at Cyclic Adenosine 3',5'-Monophosphate Response Elements in Glioma Cells Expressing Estrogen Receptor Alpha Endocrinology, April 1, 2006; 147(4): 1796 - 1804. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
