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Transforming Growth Factor-ß1 to the Bone

Department of Medical Genetics (K.J., W.V.H.), University of Antwerp, 2610 Antwerp, Belgium; Department of Molecular Cell Biology (P.t.D.), Leids Universitair Medisch Centrum, 2333 AL Leiden, The Netherlands; and Department of Biochemistry (S.J.), University of Lausanne, 1066 Epalinges-Lausanne, Switzerland

Correspondence: Address all correspondence and requests for reprints to: Professor Dr. Wim Van Hul, Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, Building T6, Universiteitsplein 1, 2610 Antwerp, Belgium. E-mail: wim.vanhul{at}ua.ac.be

TGF-ß1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-ß1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-ß1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-ß1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-ß1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.

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