This Article Full Text Full Text (PDF) All Versions of this Article: 26/1/63    most recent Final Manuscript Author Manuscript Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Böttcher, R. T. Articles by Niehrs, C. Search for Related Content PubMed PubMed Citation Articles by Böttcher, R. T. Articles by Niehrs, C.

Fibroblast Growth Factor Signaling during Early Vertebrate Development

Division of Molecular Embryology, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany

Correspondence: Address all correspondence and requests for reprints to: Ralph T. Böttcher, Department of Molecular, Cellular and Developmental Biology, Yale University, Kline Biology Tower-244, 266 Whitney Avenue, New Haven, Connecticut 06511. E-mail: ralph.boettcher{at}yale.edu

Fibroblast growth factors (FGFs) have been implicated in diverse cellular processes including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation. This review presents our current understanding on the roles of FGF signaling, the pathways employed, and its regulation. We focus on FGF signaling during early embryonic processes in vertebrates, such as induction and patterning of the three germ layers as well as its function in the control of morphogenetic movements.

This article has been cited by other articles:

				A. N. Meyer, C. W. McAndrew, and D. J. Donoghue Nordihydroguaiaretic Acid Inhibits an Activated Fibroblast Growth Factor Receptor 3 Mutant and Blocks Downstream Signaling in Multiple Myeloma Cells Cancer Res., September 15, 2008; 68(18): 7362 - 7370. [Abstract] [Full Text] [PDF]

				I. Dostalova, P. Kavalkova, D. Haluzikova, Z. Lacinova, M. Mraz, H. Papezova, and M. Haluzik Plasma Concentrations of Fibroblast Growth Factors 19 and 21 in Patients with Anorexia Nervosa J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3627 - 3632. [Abstract] [Full Text] [PDF]

				E. T. Costa, F. L. Forti, T. G.F. Matos, A. Dermargos, F. Nakano, J. Salotti, K. M. Rocha, P. F. Asprino, C. K. Yoshihara, M. M. Koga, et al. Fibroblast Growth Factor 2 Restrains Ras-Driven Proliferation of Malignant Cells by Triggering RhoA-Mediated Senescence Cancer Res., August 1, 2008; 68(15): 6215 - 6223. [Abstract] [Full Text] [PDF]

				K. A. Schalper, N. Palacios-Prado, M. A. Retamal, K. F. Shoji, A. D. Martinez, and J. C. Saez Connexin Hemichannel Composition Determines the FGF-1-induced Membrane Permeability and Free [Ca2+]i Responses Mol. Biol. Cell, August 1, 2008; 19(8): 3501 - 3513. [Abstract] [Full Text] [PDF]

				F. Rentzsch, J. H. Fritzenwanker, C. B. Scholz, and U. Technau FGF signalling controls formation of the apical sensory organ in the cnidarian Nematostella vectensis Development, May 15, 2008; 135(10): 1761 - 1769. [Abstract] [Full Text] [PDF]

				L. M. Cotton, M. K. O'Bryan, and B. T. Hinton Cellular Signaling by Fibroblast Growth Factors (FGFs) and Their Receptors (FGFRs) in Male Reproduction Endocr. Rev., April 1, 2008; 29(2): 193 - 216. [Abstract] [Full Text] [PDF]

				V. Kolsch, P. G. Charest, and R. A. Firtel The regulation of cell motility and chemotaxis by phospholipid signaling J. Cell Sci., March 1, 2008; 121(5): 551 - 559. [Abstract] [Full Text] [PDF]

				M. Walmsley, D. Cleaver, and R. Patient Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development Blood, February 1, 2008; 111(3): 1157 - 1166. [Abstract] [Full Text] [PDF]

				A. Shimada, M. Yabusaki, H. Niwa, H. Yokoi, K. Hatta, D. Kobayashi, and H. Takeda Maternal-zygotic medaka mutants for fgfr1 reveal its essential role in the migration of the axial mesoderm but not the lateral mesoderm Development, January 15, 2008; 135(2): 281 - 290. [Abstract] [Full Text] [PDF]

				E. Rottinger, A. Saudemont, V. Duboc, L. Besnardeau, D. McClay, and T. Lepage FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development Development, January 15, 2008; 135(2): 353 - 365. [Abstract] [Full Text] [PDF]

				K. Watanabe, S. Hamada, C. Bianco, M. Mancino, T. Nagaoka, M. Gonzales, V. Bailly, L. Strizzi, and D. S. Salomon Requirement of Glycosylphosphatidylinositol Anchor of Cripto-1 for trans Activity as a Nodal Co-receptor J. Biol. Chem., December 7, 2007; 282(49): 35772 - 35786. [Abstract] [Full Text] [PDF]

				M. Wagner and M. A. Q. Siddiqui Signal Transduction in Early Heart Development (I): Cardiogenic Induction and Heart Tube Formation Experimental Biology and Medicine, July 1, 2007; 232(7): 852 - 865. [Abstract] [Full Text] [PDF]

				Q. Guo and J. Y. H. Li Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation Development, June 15, 2007; 134(12): 2251 - 2260. [Abstract] [Full Text] [PDF]

				C.-S. Hong and J.-P. Saint-Jeannet The Activity of Pax3 and Zic1 Regulates Three Distinct Cell Fates at the Neural Plate Border Mol. Biol. Cell, June 1, 2007; 18(6): 2192 - 2202. [Abstract] [Full Text] [PDF]

				B. L. Allen, T. Tenzen, and A. P. McMahon The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development Genes & Dev., May 15, 2007; 21(10): 1244 - 1257. [Abstract] [Full Text] [PDF]

				R. Goetz, A. Beenken, O. A. Ibrahimi, J. Kalinina, S. K. Olsen, A. V. Eliseenkova, C. Xu, T. A. Neubert, F. Zhang, R. J. Linhardt, et al. Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members Mol. Cell. Biol., May 1, 2007; 27(9): 3417 - 3428. [Abstract] [Full Text] [PDF]

				M. Cordenonsi, M. Montagner, M. Adorno, L. Zacchigna, G. Martello, A. Mamidi, S. Soligo, S. Dupont, and S. Piccolo Integration of TGF-{beta} and Ras/MAPK Signaling Through p53 Phosphorylation Science, February 9, 2007; 315(5813): 840 - 843. [Abstract] [Full Text] [PDF]

				E. Sanchez-Heras, F. V. Howell, G. Williams, and P. Doherty The Fibroblast Growth Factor Receptor Acid Box Is Essential for Interactions with N-Cadherin and All of the Major Isoforms of Neural Cell Adhesion Molecule J. Biol. Chem., November 17, 2006; 281(46): 35208 - 35216. [Abstract] [Full Text] [PDF]

				V. S. Aggarwal, J. Liao, A. Bondarev, T. Schimmang, M. Lewandoski, J. Locker, A. Shanske, M. Campione, and B. E. Morrow Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy Hum. Mol. Genet., November 1, 2006; 15(21): 3219 - 3228. [Abstract] [Full Text] [PDF]

				S. Maegawa, M. Varga, and E. S. Weinberg FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer Development, August 15, 2006; 133(16): 3265 - 3276. [Abstract] [Full Text] [PDF]

				D. D. Michael, I. M. Alvarez, O. M. Ocon, A. M. Powell, N. C. Talbot, S. E. Johnson, and A. D. Ealy Fibroblast Growth Factor-2 Is Expressed by the Bovine Uterus and Stimulates Interferon-{tau} Production in Bovine Trophectoderm Endocrinology, July 1, 2006; 147(7): 3571 - 3579. [Abstract] [Full Text] [PDF]

				V. V. Kiselyov, E. Bock, V. Berezin, and F. M. Poulsen NMR structure of the first Ig module of mouse FGFR1. Protein Sci., June 1, 2006; 15(6): 1512 - 1515. [Abstract] [Full Text] [PDF]

				M. Poulain, M. Furthauer, B. Thisse, C. Thisse, and T. Lepage Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling Development, June 1, 2006; 133(11): 2189 - 2200. [Abstract] [Full Text] [PDF]

				J. L. Tomsig and T. T. Turner Growth Factors and the Epididymis J Androl, May 1, 2006; 27(3): 348 - 357. [Full Text] [PDF]

				J. Lu, R. Hou, C. J. Booth, S.-H. Yang, and M. Snyder Defined culture conditions of human embryonic stem cells PNAS, April 11, 2006; 103(15): 5688 - 5693. [Abstract] [Full Text] [PDF]

				R. V. Hoch and P. Soriano Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development Development, February 15, 2006; 133(4): 663 - 673. [Abstract] [Full Text] [PDF]

				A. Logan, Z. Ahmed, A. Baird, A. M. Gonzalez, and M. Berry Neurotrophic factor synergy is required for neuronal survival and disinhibited axon regeneration after CNS injury Brain, February 1, 2006; 129(2): 490 - 502. [Abstract] [Full Text] [PDF]

				B. Xie, E. Tassi, M. R. Swift, K. McDonnell, E. T. Bowden, S. Wang, Y. Ueda, Y. Tomita, A. T. Riegel, and A. Wellstein Identification of the Fibroblast Growth Factor (FGF)-interacting Domain in a Secreted FGF-binding Protein by Phage Display J. Biol. Chem., January 13, 2006; 281(2): 1137 - 1144. [Abstract] [Full Text] [PDF]

				M. Delfino-Machin, J. S. Lunn, D. N. Breitkreuz, J. Akai, and K. G. Storey Specification and maintenance of the spinal cord stem zone Development, October 1, 2005; 132(19): 4273 - 4283. [Abstract] [Full Text] [PDF]

				M.-C. Delfini, J. Dubrulle, P. Malapert, J. Chal, and O. Pourquie Control of the segmentation process by graded MAPK/ERK activation in the chick embryo PNAS, August 9, 2005; 102(32): 11343 - 11348. [Abstract] [Full Text] [PDF]

				T. Biederer Progress from the Postsynaptic Side: Signaling in Synaptic Differentiation Sci. Signal., March 8, 2005; 2005(274): pe9 - pe9. [Abstract] [Full Text] [PDF]