| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Harvard Medical School (C.B., S.S., C.R.K., A.B.G.), Boston, Massachusetts 02115; Joslin Diabetes Center (C.B., S.S., C.R.K., A.B.G.), Boston, Massachusetts 02215; and Beth Israel Deaconess Medical Center (S.S., C.R.K., A.B.G.), Boston, Massachusetts 02215
Correspondence: Address all correspondence and requests for reprints to: Allison B. Goldfine, M.D., Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215. E-mail: allison.goldfine{at}joslin.harvard.edu
Type 2 diabetes is a complex disorder with diminished insulin secretion and insulin action contributing to the hyperglycemia and wide range of metabolic defects that underlie the disease. The contribution of glucose metabolic pathways per se in the pathogenesis of the disease remains unclear. The cellular fate of glucose begins with glucose transport and phosphorylation. Subsequent pathways of glucose utilization include aerobic and anaerobic glycolysis, glycogen formation, and conversion to other intermediates in the hexose phosphate or hexosamine biosynthesis pathways. Abnormalities in each pathway may occur in diabetic subjects; however, it is unclear whether perturbations in these may lead to diabetes or are a consequence of the multiple metabolic abnormalities found in the disease. This review is focused on the cellular fate of glucose and relevance to human type 2 diabetes.
This article has been cited by other articles:
 |
|
 |
|
  S. Patel, B. W. Doble, K. MacAulay, E. M. Sinclair, D. J. Drucker, and J. R. Woodgett Tissue-Specific Role of Glycogen Synthase Kinase 3{beta} in Glucose Homeostasis and Insulin Action Mol. Cell. Biol., October 15, 2008; 28(20): 6314 - 6328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Copeland, J. W. Bullen, and G. W. Hart Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E17 - E28. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Essop Cardiac metabolic adaptations in response to chronic hypoxia J. Physiol., November 1, 2007; 584(3): 715 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Rodgers and P. Puigserver Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1 PNAS, July 31, 2007; 104(31): 12861 - 12866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N.M. Weijers and D. J. Bekedam Relationship between Gestational Diabetes Mellitus and Type 2 Diabetes: Evidence of Mitochondrial Dysfunction Clin. Chem., March 1, 2007; 53(3): 377 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chen, B. Brar, C. S. Choi, D. Rousso, J. Vaughan, Y. Kuperman, S. N. Kim, C. Donaldson, S. M. Smith, P. Jamieson, et al. Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle PNAS, October 31, 2006; 103(44): 16580 - 16585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. La Fontaine, L. B. Harkless, C. E. Davis, M. A. Allen, and P. K. Shireman Current concepts in diabetic microvascular dysfunction. J Am Podiatr Med Assoc, May 1, 2006; 96(3): 245 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Marshall, O. Nadeau, and K. Yamasaki Glucosamine-induced Activation of Glycogen Biosynthesis in Isolated Adipocytes: EVIDENCE FOR A RAPID ALLOSTERIC CONTROL MECHANISM WITHIN THE HEXOSAMINE BIOSYNTHESIS PATHWAY J. Biol. Chem., March 25, 2005; 280(12): 11018 - 11024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Del Guerra, R. Lupi, L. Marselli, M. Masini, M. Bugliani, S. Sbrana, S. Torri, M. Pollera, U. Boggi, F. Mosca, et al. Functional and Molecular Defects of Pancreatic Islets in Human Type 2 Diabetes Diabetes, March 1, 2005; 54(3): 727 - 735. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
