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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions¹

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390

Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.

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				J. Xie and M. S. Roberson 3', 5'-Cyclic Adenosine 5'-Monophosphate Response Element-Dependent Transcriptional Regulation of the Secretogranin II Gene Promoter Depends on Gonadotropin-Releasing Hormone-Induced Mitogen-Activated Protein Kinase Activation and the Transactivator Activating Transcription Factor 3 Endocrinology, February 1, 2008; 149(2): 783 - 792. [Abstract] [Full Text] [PDF]

				A. Yogi, C. Mercure, J. Touyz, G. E. Callera, A. C.I. Montezano, A. B. Aranha, R. C. Tostes, T. Reudelhuber, and R. M. Touyz Renal Redox-Sensitive Signaling, but Not Blood Pressure, Is Attenuated by Nox1 Knockout in Angiotensin II-Dependent Chronic Hypertension Hypertension, February 1, 2008; 51(2): 500 - 506. [Abstract] [Full Text] [PDF]

				Y. Wang, M. Zhu, M. Ayalew, and J. A. Ruff Down-regulation of Pkc1-mediated Signaling by the Deubiquitinating Enzyme Ubp3 J. Biol. Chem., January 25, 2008; 283(4): 1954 - 1961. [Abstract] [Full Text] [PDF]

				M.-H. Lee, H. M. El-Shewy, D. K. Luttrell, and L. M. Luttrell Role of -Arrestin-mediated Desensitization and Signaling in the Control of Angiotensin AT1a Receptor-stimulated Transcription J. Biol. Chem., January 25, 2008; 283(4): 2088 - 2097. [Abstract] [Full Text] [PDF]

				L. Li, E. Abdel Fattah, G. Cao, C. Ren, G. Yang, A. A. Goltsov, A. C. Chinault, W.-W. Cai, T. L. Timme, and T. C. Thompson Glioma Pathogenesis-Related Protein 1 Exerts Tumor Suppressor Activities through Proapoptotic Reactive Oxygen Species c-Jun NH2 Kinase Signaling Cancer Res., January 15, 2008; 68(2): 434 - 443. [Abstract] [Full Text] [PDF]

				J.-A. Ko, Y. Liu, R. Yanai, T.-i. Chikama, T. Takezawa, and T. Nishida Upregulation of Tight-Junctional Proteins in Corneal Epithelial Cells by Corneal Fibroblasts in Collagen Vitrigel Cultures Invest. Ophthalmol. Vis. Sci., January 1, 2008; 49(1): 113 - 119. [Abstract] [Full Text] [PDF]

				D. J. Weiss, C. D. Souza, O. A. Evanson, M. Sanders, and M. Rutherford Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium J. Leukoc. Biol., January 1, 2008; 83(1): 48 - 55. [Abstract] [Full Text] [PDF]

				C. G. Ziegler, F. Sicard, P. Lattke, S. R. Bornstein, M. Ehrhart-Bornstein, and A. W. Krug Dehydroepiandrosterone Induces a Neuroendocrine Phenotype in Nerve Growth Factor-Stimulated Chromaffin Pheochromocytoma PC12 Cells Endocrinology, January 1, 2008; 149(1): 320 - 328. [Abstract] [Full Text] [PDF]

				G. W. Pearson and T. Hunter Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells J. Cell Biol., December 31, 2007; 179(7): 1555 - 1567. [Abstract] [Full Text] [PDF]

				J. Wang, J.-Y. Zhou, and G. S. Wu ERK-Dependent MKP-1 Mediated Cisplatin Resistance in Human Ovarian Cancer Cells Cancer Res., December 15, 2007; 67(24): 11933 - 11941. [Abstract] [Full Text] [PDF]

				H. Vaidyanathan, J. Opoku-Ansah, S. Pastorino, H. Renganathan, M. L. Matter, and J. W. Ramos ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15 PNAS, December 11, 2007; 104(50): 19837 - 19842. [Abstract] [Full Text] [PDF]

				M. Nakamura, B. Han, T. Nishishita, Y. Bai, and K. Kakudo Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers J. Mol. Endocrinol., December 1, 2007; 39(6): 375 - 384. [Abstract] [Full Text] [PDF]

				M.-Y. Han, H. Kosako, T. Watanabe, and S. Hattori Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Regulates Actin Organization and Cell Motility by Phosphorylating the Actin Cross-Linking Protein EPLIN Mol. Cell. Biol., December 1, 2007; 27(23): 8190 - 8204. [Abstract] [Full Text] [PDF]

				T. Vomastek, M. P. Iwanicki, H.-J. Schaeffer, A. Tarcsafalvi, J. T. Parsons, and M. J. Weber RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility Mol. Cell. Biol., December 1, 2007; 27(23): 8296 - 8305. [Abstract] [Full Text] [PDF]

				W. O. Sampaio, C. Henrique de Castro, R. A.S. Santos, E. L. Schiffrin, and R. M. Touyz Angiotensin-(1-7) Counterregulates Angiotensin II Signaling in Human Endothelial Cells Hypertension, December 1, 2007; 50(6): 1093 - 1098. [Abstract] [Full Text] [PDF]

				D. Gu, W. A. Beltran, Z. Li, G. M. Acland, and G. D. Aguirre Clinical Light Exposure, Photoreceptor Degeneration, and AP-1 Activation: A Cell Death or Cell Survival Signal in the Rhodopsin Mutant Retina? Invest. Ophthalmol. Vis. Sci., November 1, 2007; 48(11): 4907 - 4918. [Abstract] [Full Text] [PDF]

				H. J. Bootsma, M. Egmont-Petersen, and P. W. M. Hermans Analysis of the In Vitro Transcriptional Response of Human Pharyngeal Epithelial Cells to Adherent Streptococcus pneumoniae: Evidence for a Distinct Response to Encapsulated Strains Infect. Immun., November 1, 2007; 75(11): 5489 - 5499. [Abstract] [Full Text] [PDF]

				J. Cheetham, D. A. Smith, A. da Silva Dantas, K. S. Doris, M. J. Patterson, C. R. Bruce, and J. Quinn A Single MAPKKK Regulates the Hog1 MAPK Pathway in the Pathogenic Fungus Candida albicans Mol. Biol. Cell, November 1, 2007; 18(11): 4603 - 4614. [Abstract] [Full Text] [PDF]

				E. Szatmari, K. B. Kalita, G. Kharebava, and M. Hetman Role of Kinase Suppressor of Ras-1 in Neuronal Survival Signaling by Extracellular Signal-Regulated Kinase 1/2 J. Neurosci., October 17, 2007; 27(42): 11389 - 11400. [Abstract] [Full Text] [PDF]

				S.-W. Kim, J. S. Hong, S.-H. Ryu, W.-C. Chung, J.-H. Yoon, and J. S. Koo Regulation of Mucin Gene Expression by CREB via a Nonclassical Retinoic Acid Signaling Pathway Mol. Cell. Biol., October 1, 2007; 27(19): 6933 - 6947. [Abstract] [Full Text] [PDF]

				C.-H. Teng, W.-N. Huang, and T.-C. Meng Several Dual Specificity Phosphatases Coordinate to Control the Magnitude and Duration of JNK Activation in Signaling Response to Oxidative Stress J. Biol. Chem., September 28, 2007; 282(39): 28395 - 28407. [Abstract] [Full Text] [PDF]