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Novel Nonimmunological Forms of β-Cell Dysfunction: Diabetic Syndromes and Pathogenic Mechanisms

Editor-in-Chief, Endocrine Reviews Guest Associate Editor, Endocrine Review Pacific Northwest Diabetes Research Institute Seattle, Washington 98122

This special edition of Endocrine Reviews features our annual Recent Progress in Hormone Research (RPHR) issue. RPHR has a venerable past history that no one in The Endocrine Society wants forgotten. It began as a group of reports from the Laurentian Conference in 1947, and, although this conference has given way to others, RPHR continues to be published unabated in Endocrine Reviews. These articles are meant to be shorter and more focused on the authors’ own work, although the usual fastidious attention to proper referencing of seminal work by others that is a hallmark of Endocrine Reviews remains emphasized.

These eight articles address the gamut of nonimmunologically based diabetes from genetics to molecular biology, from pathogenesis to clinical presentations, from the young to the old, and from laboratory data to therapeutics. Here you will find gene studies of monogenic diabetes in the young; an update on genetic studies of nonimmunological forms of diabetes encountered with the first 6 months of life; syndromes of ketosis in diabetes unrelated to type 1 diabetes; the pathogenic role of islet amyloid and toxic oligomers in type 2 diabetes; the role of the unfolded protein response in preserving β-cell homeostasis during unbridled synthesis of proteins in the endoplasmic reticulum; the role of cytokines in the pathogenesis of type 2 diabetes; elucidation of mechanisms of glucolipotoxicity that derive from chronic hyperglycemia and add a second wave of insult to β-cells after establishment of diabetes; and the promise and limitations that incretin-like drugs have in therapy of type 2 diabetes.

We know you will find these articles accessible and the concepts within them exciting to think about. The authors have been selected because they are acknowledged experts in their areas of interest. Given the current worldwide tsunami of nonimmunological diabetes, the authors’ information provides a solid knowledge base with which to create new strategies to stem the rising tide of diabetes occurring globally.

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Robertson, R. P. Articles by Aguilar-Bryan, L. Search for Related Content PubMed PubMed Citation Articles by Robertson, R. P. Articles by Aguilar-Bryan, L.