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The following is the latest addition to the Genetically Modified Animals in Endocrinology Bibliography Project. To see earlier segments of this project and links to other useful sources, go to http://www. endo-society.org/journals/bibliographies.cfm
Please send your comments, suggestions, and offerings of other relevant citations to this e-mail address: ERKO{at}endo-society.org
Protein Kinase A 1
Adams MR, Brandon EP, Chartoff EH, Idzerda RL, Dorsa DM, McKnight GS 1997 Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice. Proc Natl Acad Sci USA 94:12157–12161
Amieux P, McKnight GS 2002 The essential role of R1
in the maintenance of regulated PKA activity. Ann NY Acad Sci 968:75–95[Medline]
Amieux PS, Cummings DE, Motamed K, Brandon EP, Wailes LA, Le K, Idzerda RL, McKnight GS 1997 Compensatory regulation of Rl protein levels in protein kinase A mutant mice. J Biol Chem 272:3993–3998
Amieux PS, Howe DG, Knickerbocker H, Lee DC, Su T, Laszlo GS, Idzerda RL, McKnight GS 2002 Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem 277:27294–27304
Antos CL, Frey N, Marx SO, Reiken S, Gaburjakova M, Richardson JA, Marks AR, Olson EN 2001 Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase A. Circ Res 89:997–1004
Belyamani M, Gangolli EA, Idzerda RL 2001 Reproductive function in protein kinase inhibitor-deficient mice. Mol Cell Biol 21:3959–3963
Bisognano JD, Weinberger HD, Bohlmeyer TJ, Pende A, Raynolds MV, Sastravaha A, Roden R, Asano K, Blaxall BC, Wu SC, Communal C, Singh K, Colucci W, Bristow MR, Port DJ 2000 Myocardial-directed overexpression of the human ß(1)-adrenergic receptor in transgenic mice. J Mol Cell Cardiol 32:817–830[CrossRef][Medline]
Brandon EP, Idzerda RL, McKnight GS 1995 Targeting the mouse genome: a compendium of knockouts (part I). Curr Biol [Erratum (1995) 5:1073] 5:625–635
Brandon EP, Idzerda RL, McKnight GS 1995 Targeting the mouse genome: a compendium of knockouts (part II). Curr Biol [Erratum (1995) 5:1073] 5:758–765
Brandon EP, Idzerda RL, McKnight GS 1995 Targeting the mouse genome: a compendium of knockouts (part III). Curr Biol [Erratum (1995) 5:1073] 5:873–881
Brandon EP, Idzerda RL, McKnight GS 1997 PKA isoforms, neural pathways, and behaviour: making the connection. Curr Opin Neurobiol 7:397–403[CrossRef][Medline]
Brandon EP, Logue SF, Adams MR, Qi M, Sullivan SP, Matsumoto AM, Dorsa DM, Wehner JM, McKnight GS, Idzerda RL 1998 Defective motor behavior and neural gene expression in Rllß-protein kinase A mutant mice. J Neurosci 18:3639–3649
Burton KA, Johnson BD, Hausken ZE, Westenbroek RE, Idzerda RL, Scheuer T, Scott JD, Catterall WA, McKnight GS 1997 Type II regulatory subunits are not required for the anchoring dependent modulation of Ca2+ channel activity by PKA. Proc Natl Acad Sci USA 94:11067–11072
Burton KA, Treash-Osio B, Muller CH, Dunphy EL, McKnight GS 1999 Deletion of type ll regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization. J Biol Chem 274:24131–24136
Cummings DE, Brandon EP, Planas JV, Motamed K, Idzerda RL, McKnight GS 1996 Genetically lean mice result from targeted disruption of the RIIß subunit of protein kinase A. Nature 382:622–626[CrossRef][Medline]
Engelhardt S, Hein L, Wiesmann F, Lohse MJ 1999 Progressive hypertrophy and heart failure in ß1-adrenergic receptor transgenic mice. Proc Natl Acad Sci USA 96:7059–7064
Gangolli EA, Belyamani M, Muchinsky S, Narula A, Burton KA, McKnight GS, Uhler MD, Idzerda RL 2000 Deficient gene expression in protein kinase inhibitor null mutant mice. Mol Cell Biol 20:3442–3448
Gao MH, Lai NC, Roth DM, Zhou J, Zhu J, Anzai T, Dalton N, Hammond HK 1999 Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice. Circulation 99:1618–1622
Georges-Labouesse EN, George EL, Rayburn H, Hynes RO 1996 Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn 207:145–156[CrossRef][Medline]
Hamilton SE, Loose MD, Qi M, Levey AI, Hille B, McKnight GS, Idzerda RL, Nathanson NM 1997 Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice. Proc Natl Acad Sci USA 94:13311–13316
Hensch TK, Gordon JA, Brandon EP, McKnight GS, Idzerda RL, Stryker MP 1998 Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and PKA RIß-deficient mice. J Neurosci 18:2108–2117
Howe DG, Wiley JC, McKnight GS 2002 Molecular and behavioral effects of a null mutation in all PKA Cß isoforms. Mol Cell Neurosci 20:515–524[CrossRef][Medline]
Huang Y, Roelink H, McKnight GS 2002 Protein kinase A deficiency causes axially localized neural tube defects in mice. J Biol Chem 277:19889–19896
Huang YY, Kandel ER, Varshavsky L, Brandon EP, Qi M, Idzerda RL, McKnight GS, Bourtchouladze R 1995 A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning. Cell 83:1211–1222[CrossRef][Medline]
Iwase M, Bishop SP, Uechi M, Vatner DE, Shannon RP, Kudej RK, Wight DC, Wagner TE, Ishikawa Y, Homcy CJ, Vatner SF 1996 Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS overexpression. Circ Res 78:517–524
Le Y, Sauer B 2000 Conditional gene knockout using cre recombinase. Methods Mol Biol 136:477–485[Medline]
Lipskaia L, Defer N, Esposito G, Hajar I, Garel MC, Rockman HA, Hanoune J 2000 Enhanced cardiac function in transgenic mice expressing a Ca2+-stimulated adenylyl cyclase. Circ Res 86:795–801
Lohse MJ, Engelhardt S 2001 Protein kinase A transgenes: the many faces of cAMP. Cir Res 89:938–940
Malmberg AB, Brandon EP, Idzerda RL, Liu H, McKnight GS, Basbaum AI 1997 Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase. J Neurosci 17:7462–7470
McKnight GS, Cummings DE, Amieux PS, Sikorski MA, Brandon EP, Planas JV, Motamed K, Idzerda RL 1998 Cyclic AMP, PKA, and the physiological regulation of adiposity. Recent Prog Horm Res 53:139–161
Niswender CM, McKnight GS, Transgenic models for the study of protein kinase A-regulated signal transduction. In: Handbook of experimental pharmacology. Heidelberg: Springer-Verlag, in press
Planas JV, Cummings DE, Idzerda RL, McKnight GS 1999 Mutation of the RIIbeta subunit of protein kinase A differentially affects lipolysis but not gene induction in white adipose tissue. J Biol Chem 274:36281–36287
Qi M, Zhou M, Skalhegg BS, Brandon EP, Kandel ER, McKnight GS, Idzerda RL 1996 Impaired hippocampal plasticity in mice lacking the Cß1 catalytic subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci USA 93:1571–1576
Schreyer SA, Cummings DE, McKnight GS, LeBoeuf RC 2001 Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice. Diabetes 50:2555–2562
Skalhegg BS, Huang Y, Su T, Idzerda RL, McKnight GS, Burton KA 2002 Mutation of the C subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol 16:630–639
Sun X, Meyers EN, Lewandoski M, Martin GR 1999 Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev 13:1834–1846
Thiele TE, Willis B, Stadler J, Reynolds JG, Bernstein IL, McKnight GS 2000 High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice. J Neurosci 20:RC75
Wu JY, Ribar TJ, Cummings DE, Burton KA, McKnight GS, Means AR 2000 Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. Nat Genet 25:448–452[CrossRef][Medline]
Footnotes
1 We thank G. Stanley McKnight for advising Endocrine Reviews concerning this segment of the Genetically Modified Animals in Endocrinology Bibliography Project. Dr. McKnight is with the Department of Pharmacology at the University of Washington (Seattle). 
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