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Genetically Modified Animals in Endocrinology

The following is the latest addition to the Genetically Modified Animals in Endocrinology Bibliography Project. To see earlier segments of this project, go to http://www.endo-society.org/journals/bibliographies.cfm

Please send your comments, suggestions, and offerings of other relevant citations to this e-mail address: ERKO{at}endo-society.org

Hormonal Generation of Calcium Signals, Part I¹

PLCß Family
PLCß1 (also PLCß4)
Kim D, Jun KS, Lee SB, Kang NG, Min DS, Kim YH, Ryu SH, Suh PG, Shin HS 1997 Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature 389:290–293[CrossRef][Medline]

PLCß2
Jiang H, Kuang Y, Wu Y, Xie W, Simon MI, Wu D 1997 Roles of phospholipase Cß2 in chemoattractant-elicited responses. Proc Natl Acad Sci USA 94:7971–7975[Abstract/Free Full Text]

PLCß3
Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D 1999 Genetic alteration of phospholipase Cß3 expression modulates behavioral and cellular responses to mu opioids. Proc Natl Acad Sci USA 96:10385–10390[Abstract/Free Full Text]

PLCß4
Kano M, Hashimoto K, Watanabe M, Kurihara H, Offermanns S, Jiang H, Wu Y, Jun K, Shin HS, Inoue Y, Simon MI, Wu D 1998 Phospholipase cß4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum. Proc Natl Acad Sci USA 95:15724–15729[Abstract/Free Full Text]

PLC Family
PLC1
Ji QS, Winnier GE, Niswender KD, Horstman D, Wisdom R, Magnuson MA, Carpenter G 1997 Essential role of the tyrosine kinase substrate phospholipase C1 in mammalian growth and development. Proc Natl Acad Sci USA 94:2999–3003[Abstract/Free Full Text]

PLC2
Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, Ihle JN 2000 Phospholipase C2 is essential in the functions of B cell and several Fc receptors. Immunity 13:25–35[CrossRef][Medline]

IP3 Receptors
IP3R1
Matsumoto M, Nakagawa T, Inoue T, Nagata E, Tanaka K, Takano H, Minowa O, Kuno J, Sakakibara S, Yamada M, Yoneshima H, Miyawaki A, Fukuuchi Y, Furuichi T, Okano H, Mikoshiba K, Noda T 1996 Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature 379:168–171[CrossRef][Medline]

Ryanodine Receptors
RyR1
Takeshima H, Iino M, Takekura H, Nishi M, Kuno J, Minowa O, Takano H, Noda T 1994 Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene. Nature 369:556–559[CrossRef][Medline]

RyR2
Takeshima H, Komazaki S, Hirose K, Nishi M, Noda T, Iino M 1998 Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2. EMBO J 17:3309–3316[CrossRef][Medline]

RyR3
Bertocchini F, Ovitt CE, Conti A, Barone V, Scholer HR, Bottinelli R, Reggiani C, Sorrentino V 1997 Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J 16:6956–6963[CrossRef][Medline]

SERCAs
SERCA2
Periasamy M, Reed TD, Liu LH, Ji Y, Loukianov E, Paul RJ, Nieman ML, Riddle T, Duffy JJ, Doetschman T, Lorenz JN, Shull GE 1999 Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca²⁺-ATPase isoform 2 (SERCA2) gene. J Biol Chem 274:2556–2562[Abstract/Free Full Text]

SERCA2a
Ver Heyen M, Heymans S, Antoons G, Reed T, Periasamy M, Awede B, Lebacq J, Vangheluwe P, Dewerchin M, Collen D, Sipido K, Carmeliet P, Wuytack F 2001 Replacement of the muscle-specific sarcoplasmic reticulum Ca²⁺-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart. Circ Res 89:838–846[Abstract/Free Full Text]

SERCA3
Liu LH, Paul RJ, Sutliff RL, Miller ML, Lorenz JN, Pun RY, Duffy JJ, Doetschman T, Kimura Y, MacLennan DH, Hoying JB, Shull GE 1997 Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca²⁺ signaling in mice lacking sarco(endo)plasmic reticulum Ca²⁺-ATPase isoform 3. J Biol Chem 272:30538–30545[Abstract/Free Full Text]

PMCAs
PMCA2
Kozel PJ, Friedman RA, Erway LC, Yamoah EN, Liu LH, Riddle T, Duffy JJ, Doetschman T, Miller ML, Cardell EL, Shull GE 1998 Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca²⁺-ATPase isoform 2. J Biol Chem 273:18693–18696[Abstract/Free Full Text]

Footnotes

¹ We thank Patricia M. Hinkle for providing this segment of the Genetically Altered Animals in Endocrinology Bibliography Project. Dr. Hinkle is a professor in the Department of Pharmacology and Physiology at the University of Rochester Medical Center.

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content