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BENTLEY CHEATHAM and C. RONALD KAHN
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S. Dadke and J. Chernoff Protein-tyrosine Phosphatase 1B Mediates the Effects of Insulin on the Actin Cytoskeleton in Immortalized Fibroblasts J. Biol. Chem., October 17, 2003; 278(42): 40607 - 40611. [Abstract] [Full Text] [PDF]
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J. M. Boylan and P. A. Gruppuso Insulin Receptor Substrate-1 Is Present in Hepatocyte Nuclei from Intact Rats Endocrinology, November 1, 2002; 143(11): 4178 - 4183. [Abstract] [Full Text] [PDF]
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G. Pandini, F. Frasca, R. Mineo, L. Sciacca, R. Vigneri, and A. Belfiore Insulin/Insulin-like Growth Factor I Hybrid Receptors Have Different Biological Characteristics Depending on the Insulin Receptor Isoform Involved J. Biol. Chem., October 11, 2002; 277(42): 39684 - 39695. [Abstract] [Full Text] [PDF]
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T. Saitoh, T. Yanagita, S. Shiraishi, H. Yokoo, H. Kobayashi, S.-i. Minami, T. Onitsuka, and A. Wada Down-Regulation of Cell Surface Insulin Receptor and Insulin Receptor Substrate-1 Phosphorylation by Inhibitor of 90-kDa Heat-Shock Protein Family: Endoplasmic Reticulum Retention of Monomeric Insulin Receptor Precursor with Calnexin in Adrenal Chromaffin Cells Mol. Pharmacol., October 1, 2002; 62(4): 847 - 855. [Abstract] [Full Text] [PDF]
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T. A. Davis, M. L. Fiorotto, D. G. Burrin, R. C. Vann, P. J. Reeds, H. V. Nguyen, P. R. Beckett, and J. A. Bush Acute IGF-I infusion stimulates protein synthesis in skeletal muscle and other tissues of neonatal pigs Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E638 - E647. [Abstract] [Full Text] [PDF]
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S. Gogg and U. Smith Epidermal Growth Factor and Transforming Growth Factor alpha Mimic the Effects of Insulin in Human Fat Cells and Augment Downstream Signaling in Insulin Resistance J. Biol. Chem., September 20, 2002; 277(39): 36045 - 36051. [Abstract] [Full Text] [PDF]
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 M. Li, J. F. Youngren, A. Dunaif, I. D. Goldfine, B. A. Maddux, B. B. Zhang, and J. L. Evans Decreased Insulin Receptor (IR) Autophosphorylation in Fibroblasts from Patients with PCOS: Effects of Serine Kinase Inhibitors and IR Activators J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4088 - 4093. [Abstract] [Full Text] [PDF]
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D. Huang, A. T. Cheung, J. T. Parsons, and M. Bryer-Ash Focal Adhesion Kinase (FAK) Regulates Insulin-stimulated Glycogen Synthesis in Hepatocytes J. Biol. Chem., May 10, 2002; 277(20): 18151 - 18160. [Abstract] [Full Text] [PDF]
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M. Otala, K. Erkkila, T. Tuuri, J. Sjoberg, L. Suomalainen, A-M. Suikkari, V. Pentikainen, and L. Dunkel Cell death and its suppression in human ovarian tissue culture Mol. Hum. Reprod., March 1, 2002; 8(3): 228 - 236. [Abstract] [Full Text] [PDF]
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T. Kabuta, F. Hakuno, T. Asano, and S.-I. Takahashi Insulin Receptor Substrate-3 Functions as Transcriptional Activator in the Nucleus J. Biol. Chem., February 22, 2002; 277(9): 6846 - 6851. [Abstract] [Full Text] [PDF]
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R. A. Booth, C. Cummings, M. Tiberi, and X. J. Liu GIPC Participates in G Protein Signaling Downstream of Insulin-like Growth Factor 1 Receptor J. Biol. Chem., February 15, 2002; 277(8): 6719 - 6725. [Abstract] [Full Text] [PDF]
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M. Murata, Y. Okimura, K. Iida, M. Matsumoto, H. Sowa, H. Kaji, M. Kojima, K. Kangawa, and K. Chihara Ghrelin Modulates the Downstream Molecules of Insulin Signaling in Hepatoma Cells J. Biol. Chem., February 8, 2002; 277(7): 5667 - 5674. [Abstract] [Full Text] [PDF]
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J. Eichhorn, A. G. Kayali, L. Resor, D. A. Austin, D. W. Rose, and N. J. G. Webster PLC-{gamma}1 Enzyme Activity Is Required for Insulin-Induced DNA Synthesis Endocrinology, February 1, 2002; 143(2): 655 - 664. [Abstract] [Full Text] [PDF]
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K. F. Howlett, K. Sakamoto, M. F. Hirshman, W. G. Aschenbach, M. Dow, M. F. White, and L. J. Goodyear Insulin Signaling After Exercise in Insulin Receptor Substrate-2-Deficient Mice Diabetes, February 1, 2002; 51(2): 479 - 483. [Abstract] [Full Text] [PDF]
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S. F. Kralik, P. Liu, B. J. Leffler, and J. S. Elmendorf Ceramide and Glucosamine Antagonism of Alternate Signaling Pathways Regulating Insulin- and Osmotic Shock-Induced Glucose Transporter 4 Translocation Endocrinology, January 1, 2002; 143(1): 37 - 46. [Abstract] [Full Text] [PDF]
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X. Huang, A. Vaag, M. Hansson, and L. Groop Down-Regulation of Insulin Receptor Substrates (IRS)-1 and IRS-2 and Src Homologous and Collagen-Like Protein Shc Gene Expression by Insulin in Skeletal Muscle Is Not Associated with Insulin Resistance or Type 2 Diabetes J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 255 - 259. [Abstract] [Full Text] [PDF]
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M. J. Pagliassotti, J. Kang, J. S. Thresher, C. K. Sung, and M. E. Bizeau Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E170 - E176. [Abstract] [Full Text] [PDF]
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L. Laviola, G. Belsanti, A. M. Davalli, R. Napoli, S. Perrini, G. C. Weir, R. Giorgino, and F. Giorgino Effects of Streptozocin Diabetes and Diabetes Treatment by Islet Transplantation on In Vivo Insulin Signaling in Rat Heart Diabetes, December 1, 2001; 50(12): 2709 - 2720. [Abstract] [Full Text] [PDF]
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M. J. Wick, L. Q. Dong, D. Hu, P. Langlais, and F. Liu Insulin Receptor-mediated p62dok Tyrosine Phosphorylation at Residues 362 and 398 Plays Distinct Roles for Binding GTPase-activating Protein and Nck and Is Essential for Inhibiting Insulin-stimulated Activation of Ras and Akt J. Biol. Chem., November 9, 2001; 276(46): 42843 - 42850. [Abstract] [Full Text] [PDF]
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S. Apparsundaram, U. Sung, R. D. Price, and R. D. Blakely Trafficking-Dependent and -Independent Pathways of Neurotransmitter Transporter Regulation Differentially Involving p38 Mitogen-Activated Protein Kinase Revealed in Studies of Insulin Modulation of Norepinephrine Transport in SK-N-SH Cells J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 666 - 677. [Abstract] [Full Text] [PDF]
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J. Dupont, J. Khan, B.-H. Qu, P. Metzler, L. Helman, and D. LeRoith Insulin and IGF-1 Induce Different Patterns of Gene Expression in Mouse Fibroblast NIH-3T3 Cells: Identification by cDNA Microarray Analysis Endocrinology, November 1, 2001; 142(11): 4969 - 4975. [Abstract] [Full Text] [PDF]
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P. Boileau, M. Cauzac, M. A. Pereira, J. Girard, and S. Hauguel-de Mouzon Dissociation between Insulin-Mediated Signaling Pathways and Biological Effects in Placental Cells: Role of Protein Kinase B and MAPK Phosphorylation Endocrinology, September 1, 2001; 142(9): 3974 - 3979. [Abstract] [Full Text] [PDF]
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A. Takano, I. Usui, T. Haruta, J. Kawahara, T. Uno, M. Iwata, and M. Kobayashi Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin Mol. Cell. Biol., August 1, 2001; 21(15): 5050 - 5062. [Abstract] [Full Text] [PDF]
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L. Shefi-Friedman, E. Wertheimer, S. Shen, A. Bak, D. Accili, and S. R. Sampson Increased IGFR activity and glucose transport in cultured skeletal muscle from insulin receptor null mice Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E16 - E24. [Abstract] [Full Text] [PDF]
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L. A. Nolte, K. E. Yarasheski, K. Kawanaka, J. Fisher, N. Le, and J. O. Holloszy The HIV Protease Inhibitor Indinavir Decreases Insulin- and Contraction-Stimulated Glucose Transport in Skeletal Muscle Diabetes, June 1, 2001; 50(6): 1397 - 1401. [Abstract] [Full Text]
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V. A. Skeberdis, J.-y. Lan, X. Zheng, R. S. Zukin, and M. V. L. Bennett Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis PNAS, March 13, 2001; 98(6): 3561 - 3566. [Abstract] [Full Text] [PDF]
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 L.-P. Weng, W. M. Smith, J. L. Brown, and C. Eng PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model Hum. Mol. Genet., March 1, 2001; 10(6): 605 - 616. [Abstract] [Full Text] [PDF]
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J. J. Carrillo, B. Ibares, A. Esteban-Gamboa, and J. E. Feliu Involvement of Both Phosphatidylinositol 3-Kinase and p44/p42 Mitogen-Activated Protein Kinase Pathways in the Short-Term Regulation of Pyruvate Kinase L by Insulin Endocrinology, March 1, 2001; 142(3): 1057 - 1064. [Abstract] [Full Text] [PDF]
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 D. Le Roith and Y. Zick Recent Advances in Our Understanding of Insulin Action and Insulin Resistance Diabetes Care, March 1, 2001; 24(3): 588 - 597. [Abstract] [Full Text]
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S. Shen, A. Alt, E. Wertheimer, M. Gartsbein, T. Kuroki, M. Ohba, L. Braiman, S. R. Sampson, and T. Tennenbaum PKC{delta} Activation: A Divergence Point in the Signaling of Insulin and IGF-1--Induced Proliferation of Skin Keratinocytes Diabetes, February 1, 2001; 50(2): 255 - 264. [Abstract] [Full Text]
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M. Fasshauer, J. Klein, K. M. Kriauciunas, K. Ueki, M. Benito, and C. R. Kahn Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes Mol. Cell. Biol., January 1, 2001; 21(1): 319 - 329. [Abstract] [Full Text]
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W. T. Cefalu Insulin Resistance: Cellular and Clinical Concepts Experimental Biology and Medicine, January 1, 2001; 226(1): 13 - 26. [Abstract] [Full Text]
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S. Tang, H. Le-Tien, B. J. Goldstein, P. Shin, R. Lai, and I. G. Fantus Decreased In Situ Insulin Receptor Dephosphorylation in Hyperglycemia-Induced Insulin Resistance in Rat Adipocytes Diabetes, January 1, 2001; 50(1): 83 - 90. [Abstract] [Full Text]
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A. Bektas, J. N. Hughes, J. H. Warram, A. S. Krolewski, and A. Doria Type 2 Diabetes Locus on 12q15: Further Mapping and Mutation Screening of Two Candidate Genes Diabetes, January 1, 2001; 50(1): 204 - 208. [Abstract] [Full Text]
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K.-C. Leung, N. Doyle, M. Ballesteros, M. J. Waters, and K. K. Y. Ho Insulin Regulation of Human Hepatic Growth Hormone Receptors: Divergent Effects on Biosynthesis and Surface Translocation J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4712 - 4720. [Abstract] [Full Text]
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H. Louhio, O. Hovatta, J. Sjoberg, and T. Tuuri The effects of insulin, and insulin-like growth factors I and II on human ovarian follicles in long-term culture Mol. Hum. Reprod., August 1, 2000; 6(8): 694 - 698. [Abstract] [Full Text] [PDF]
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P. G. Drake, A. Balbis, J. Wu, J. J. M. Bergeron, and B. I. Posner Association of phosphatidylinositol 3-kinase with the insulin receptor: compartmentation in rat liver Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E266 - E274. [Abstract] [Full Text] [PDF]
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 Y. Shimoni, D. Severson, and H. S. Ewart Insulin resistance and the modulation of rat cardiac K+ currents Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H639 - H649. [Abstract] [Full Text] [PDF]
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L. F. Del Aguila, R. K. Krishnan, J. S. Ulbrecht, P. A. Farrell, P. H. Correll, C. H. Lang, J. R. Zierath, and J. P. Kirwan Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E206 - E212. [Abstract] [Full Text] [PDF]
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J. Klein, M. Fasshauer, M. Benito, and C. R. Kahn Insulin and the {beta}3-Adrenoceptor Differentially Regulate Uncoupling Protein-1 Expression Mol. Endocrinol., June 1, 2000; 14(6): 764 - 773. [Abstract] [Full Text]
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T. Haruta, T. Uno, J. Kawahara, A. Takano, K. Egawa, P. M. Sharma, J. M. Olefsky, and M. Kobayashi A Rapamycin-Sensitive Pathway Down-Regulates Insulin Signaling via Phosphorylation and Proteasomal Degradation of Insulin Receptor Substrate-1 Mol. Endocrinol., June 1, 2000; 14(6): 783 - 794. [Abstract] [Full Text]
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 J. LI, K. L. HOUSEKNECHT, A. E. STENBIT, E. B. KATZ, and M. J. CHARRON Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice FASEB J, June 1, 2000; 14(9): 1117 - 1125. [Abstract] [Full Text]
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M. L. Hribal, M. Federici, O. Porzio, D. Lauro, P. Borboni, D. Accili, R. Lauro, and G. Sesti The Gly->Arg972 Amino Acid Polymorphism in Insulin Receptor Substrate-1 Affects Glucose Metabolism in Skeletal Muscle Cells J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 2004 - 2013. [Abstract] [Full Text]
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B. Draznin, P. Miles, Y. Kruszynska, J. Olefsky, J. Friedman, I. Golovchenko, R. Stjernholm, K. Wall, M. Reitman, D. Accili, et al. Effects of Insulin on Prenylation as a Mechanism of Potentially Detrimental Influence of Hyperinsulinemia Endocrinology, April 1, 2000; 141(4): 1310 - 1316. [Abstract] [Full Text] [PDF]
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 S. Jin Chan and D. F. Steiner Insulin Through the Ages: Phylogeny of a Growth Promoting and Metabolic Regulatory Hormone Integr. Comp. Biol., April 1, 2000; 40(2): 213 - 222. [Abstract] [Full Text] [PDF]
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Z. Xie, H. Li, L. Liu, B. B. Kahn, S. M. Najjar, and W. Shah Metabolic regulation of Na+/Pi-cotransporter-1 gene expression in H4IIE cells Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E648 - E655. [Abstract] [Full Text] [PDF]
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M. Kanzaki, R. T. Watson, N. O. Artemyev, and J. E. Pessin The Trimeric GTP-binding Protein (Gq/G11) alpha Subunit Is Required for Insulin-stimulated GLUT4 Translocation in 3T3L1 Adipocytes J. Biol. Chem., March 15, 2000; 275(10): 7167 - 7175. [Abstract] [Full Text] [PDF]
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C. Desbois-Mouthon, A. Cadoret, M.-J. Blivet-Van Eggelpoel, F. Bertrand, M. Caron, A. Atfi, G. Cherqui, and J. Capeau Insulin-Mediated Cell Proliferation and Survival Involve Inhibition of c-Jun N-terminal Kinases through a Phosphatidylinositol 3-Kinase- and Mitogen-Activated Protein Kinase Phosphatase-1-Dependent Pathway Endocrinology, March 1, 2000; 141(3): 922 - 931. [Abstract] [Full Text] [PDF]
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 P. S. Hansen, K. A. Buhagiar, D. F. Gray, and H. H. Rasmussen Voltage-dependent stimulation of the Na+-K+ pump by insulin in rabbit cardiac myocytes Am J Physiol Cell Physiol, March 1, 2000; 278(3): C546 - C553. [Abstract] [Full Text] [PDF]
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C. Kausch, A. Hamann, I. Uphues, A. Niendorf, D. Müller-Wieland, H.-G. Joost, P. Algenstaedt, M. Dreyer, H. W. Rüdiger, H.-U. Häring, et al. Association of Impaired Phosphatidylinositol 3-Kinase Activity in GLUT1-Containing Vesicles with Malinsertion of Glucose Transporters into the Plasma Membrane of Fibroblasts from a Patient with Severe Insulin Resistance and Clinical Features of Werner Syndrome J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 905 - 918. [Abstract] [Full Text]
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E. Heart, W. S. Choi, and C. K. Sung Glucosamine-induced insulin resistance in 3T3-L1 adipocytes Am J Physiol Endocrinol Metab, January 1, 2000; 278(1): E103 - E112. [Abstract] [Full Text] [PDF]
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M. A. B. Reis, F. G. R. Reyes, M. J. A. Saad, and L. A. Velloso Magnesium Deficiency Modulates the Insulin Signaling Pathway in Liver but Not Muscle of Rats J. Nutr., January 1, 2000; 130(2): 133 - 138. [Abstract] [Full Text]
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 P. d. O. Prada, M. M. Okamoto, L. N. S. Furukawa, U. F. Machado, J. C. Heimann, and M. S. Dolnikoff High- or Low-Salt Diet From Weaning to Adulthood : Effect on Insulin Sensitivity in Wistar Rats Hypertension, January 1, 2000; 35(1): 424 - 429. [Abstract] [Full Text] [PDF]
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J. Klein, M. Fasshauer, M. Ito, B. B. Lowell, M. Benito, and C. R. Kahn beta 3-Adrenergic Stimulation Differentially Inhibits Insulin Signaling and Decreases Insulin-induced Glucose Uptake in Brown Adipocytes J. Biol. Chem., December 3, 1999; 274(49): 34795 - 34802. [Abstract] [Full Text] [PDF]
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W. Zhao, H. Chen, H. Xu, E. Moore, N. Meiri, M. J. Quon, and D. L. Alkon Brain Insulin Receptors and Spatial Memory. CORRELATED CHANGES IN GENE EXPRESSION, TYROSINE PHOSPHORYLATION, AND SIGNALING MOLECULES IN THE HIPPOCAMPUS OF WATER MAZE TRAINED RATS J. Biol. Chem., December 3, 1999; 274(49): 34893 - 34902. [Abstract] [Full Text] [PDF]
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C. N. Woldin, F. S. Hing, J. Lee, P. F. Pilch, and G. G. Shipley Structural Studies of the Detergent-solubilized and Vesicle-reconstituted Insulin Receptor J. Biol. Chem., December 3, 1999; 274(49): 34981 - 34992. [Abstract] [Full Text] [PDF]
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S. Y. Hsu Cloning of Two Novel Mammalian Paralogs of Relaxin/Insulin Family Proteins and Their Expression in Testis and Kidney Mol. Endocrinol., December 1, 1999; 13(12): 2163 - 2174. [Abstract] [Full Text]
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C. J. Band, C. Mounier, and B. I. Posner Epidermal Growth Factor and Insulin-Induced Deoxyribonucleic Acid Synthesis in Primary Rat Hepatocytes Is Phosphatidylinositol 3-Kinase Dependent and Dissociated from Protooncogene Induction Endocrinology, December 1, 1999; 140(12): 5626 - 5634. [Abstract] [Full Text]
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