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Effect of Growth Hormone on Carbohydrate and Lipid Metabolism

Department of Medicine, Cedars-Sinai Medical Center, University of California Los Angeles Los Angeles, California 90048

Correspondence: Address requests for reprints to: Mayer B. Davidson, M.D., Division of Endocrinology, Room 1735, 8700 Beverly Boulevard, Cedars-Sinai Medical Center, Los Angeles, California 90048.

Abstract

Introduction: APPROXIMATELY 60 yr ago, Houssay and his colleagues (1) described hypersensitivity to insulin in hypophysectomized (hypox) animals. Further work documented a primary effect of GH in this phenomenon (1). Over the ensuing years, numerous investigators have sought to define the role of GH in carbohydrate and lipid metabolism. Unfortunately, no unified picture has emerged. Both insulin-like and antiinsulin-like effects have been documented, although the physiological significance of the former is uncertain. Major controversies surround the relationship between structure and function of the GH molecule. Indeed, some believe that most of the reported effects of GH are due to contaminants in the hormone preparation. With two exceptions (2, 3), reviews in this area (4–10) have focused mainly on the author's own work in a circumscribed field; e.g. in vivo effects after GH administration (6, 7, 9), tissue effects in vitro (5, 7), or effects on lipolysis (4, 8,10). Furthermore, these reviews were published more than 10 yr ago.

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				Committee on Drugs and Committee on Bioethics Considerations Related to the Use of Recombinant Human Growth Hormone in Children Pediatrics, January 1, 1997; 99(1): 122 - 129. [Abstract] [Full Text] [PDF]

				L. S. Argetsinger, G. W. Hsu, M. G. Myers Jr., N. Billestrup, M. F. White, and C. Carter-Su Growth Hormone, Interferon-[IMAGE], and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1 J. Biol. Chem., June 16, 1995; 270(24): 14685 - 14692. [Abstract] [Full Text] [PDF]

				J. VanderKuur, G. Allevato, N. Billestrup, G. Norstedt, and C. Carter-Su Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2 J. Biol. Chem., March 31, 1995; 270(13): 7587 - 7593. [Abstract] [Full Text] [PDF]