This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by CONN, P. M. Search for Related Content PubMed PubMed Citation Articles by CONN, P. M.

The Molecular Basis of Gonadotropin-Releasing Hormone Action^*

Department of Pharmacology, University of Iowa College of Medicine Iowa City, Iowa 52242

Correspondence: Address requests for reprints to: Dr. P. Michael Conn, Department of Pharmacology, University of Iowa, College of Medicine, Iowa City, Iowa, 52240.

Abstract

Introduction: WE HAVE known for more than 15 yr that release of the pituitary gonadotropins (LH and FSH) is regulated by a decapeptide from the hypothalamus, GnRH. This releasing hormone is active in vivo, as well as in pituitary explants, and in cell cultures. Accordingly, it has been possible to obtain a great deal of data which have been used to develop an understanding of GnRH action at the cellular level. Models of GnRH action have been useful to understand and predict the actions of GnRH in vivo and to design means for using the releasing hormone in the treatment of human disorders. The present review will describe our current understanding of GnRH action and serve to update our previous review in this series (1).

Footnotes

^* This work was supported in part by NIH Grant HD-19899.

This article has been cited by other articles:

				M. Lindemans, F. Liu, T. Janssen, S. J. Husson, I. Mertens, G. Gade, and L. Schoofs Adipokinetic hormone signaling through the gonadotropin-releasing hormone receptor modulates egg-laying in Caenorhabditis elegans PNAS, February 3, 2009; 106(5): 1642 - 1647. [Abstract] [Full Text] [PDF]

				R.F. Arrais and S.A. Dib The hypothalamus-pituitary-ovary axis and type 1 diabetes mellitus: a mini review Hum. Reprod., February 1, 2006; 21(2): 327 - 337. [Abstract] [Full Text] [PDF]

				A. Nagy and A. V. Schally Targeting of Cytotoxic Luteinizing Hormone-Releasing Hormone Analogs to Breast, Ovarian, Endometrial, and Prostate Cancers Biol Reprod, November 1, 2005; 73(5): 851 - 859. [Abstract] [Full Text] [PDF]

				G. Halmos and A. V. Schally Changes in subcellular distribution of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) after treatment with the LH-RH antagonist cetrorelix PNAS, January 22, 2002; 99(2): 961 - 965. [Abstract] [Full Text] [PDF]

				M. Kovacs and A. V. Schally Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats PNAS, October 9, 2001; 98(21): 12197 - 12202. [Abstract] [Full Text] [PDF]

				T. European Middle East Orgalutran Study Group* Comparable clinical outcome using the GnRH antagonist ganirelix or a long protocol of the GnRH agonist triptorelin for the prevention of premature LH surges in women undergoing ovarian stimulation Hum. Reprod., April 1, 2001; 16(4): 644 - 651. [Abstract] [Full Text] [PDF]

				U. B. Kaiser, P. M. Conn, and W. W. Chin Studies of Gonadotropin-Releasing Hormone (GnRH) Action Using GnRH Receptor-Expressing Pituitary Cell Lines Endocr. Rev., February 1, 1997; 18(1): 46 - 70. [Abstract] [Full Text]

				J. J. Heindel and K. A. Treinen Physiology of the Male Reproductive System: Endocrine, Paracrine and Autocrine Regulation Toxicol Pathol, February 1, 1989; 17(2): 411 - 445. [Abstract] [PDF]

				M. Kovacs, A. V. Schally, B. Csernus, and Z. Rekasi Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH PNAS, February 13, 2001; 98(4): 1829 - 1834. [Abstract] [Full Text] [PDF]