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Department of Physiology and Biophysics, Indiana University School of Medicine Indianapolis, Indiana 46223
Correspondence: Address all correspondence and requests for reprints to: Dr. Nira Ben-Jonathan, Department of Physiology and Biophysics, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, Indiana 46223.
Abstract
A. Introduction: DOPAMINE (DA) is an interesting and versatile compound. In the central nervous system (CNS) it is involved with the control of fine movements and mental processes. Its association with disorders such as Parkinsonism and schizophrenia is well recognized. In the hypothalamo-hypophysial axis, DA is the primary physiological inhibitor of PRL secretion. Currently, this catecholamine represents the only nonpeptidergic hypothalamic agent with a well defined hypophysiotropic function. By virtue of its dual role as a neurotransmitter and a hormone, DA provides perhaps the best example of neuroendocrine interactions. It also possesses a more universal property. In all hormonal systems studied thus far, whether at the hypothalamic, posterior pituitary, or anterior pituitary level, DA functions as an inhibitor. Perhaps the common denominator to these diverse cells is the presence of D2 DA receptors, which are negatively linked to the adenylate cyclase system.
Footnotes
* This work was supported in part by Grants NS-13234 and Research Career Development Award NS-219 from the NIH.
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|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
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|
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|
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|
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|
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|
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|
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