Pacific Northwest Diabetes Research Institute, Seattle, Washington 98122
Correspondence: Address all correspondence and requests for reprints to: Lydia Aguilar-Bryan and Joseph Bryan, Pacific Northwest Diabetes Research Institute, 720 Broadway, Seattle, Washington 98122. E-mail: lbryan{at}pnri.org or jbryan{at}pnri.org
An explosion of work over the last decade has produced insightinto the multiple hereditary causes of a nonimmunological formof diabetes diagnosed most frequently within the first 6 monthsof life. These studies are providing increased understandingof genes involved in the entire chain of steps that controlglucose homeostasis. Neonatal diabetes is now understood toarise from mutations in genes that play critical roles in thedevelopment of the pancreas, of β-cell apoptosis and insulinprocessing, as well as the regulation of insulin release. Forthe basic researcher, this work is providing novel tools toexplore fundamental molecular and cellular processes. For theclinician, these studies underscore the need to identify thegenetic cause underlying each case. It is increasingly clearthat the prognosis, therapeutic approach, and genetic counselinga physician provides must be tailored to a specific gene inorder to provide the best medical care.
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