| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Endocrinology and the Departments of Medicine and Pharmacology (S.R.H.), University of Texas Southwestern Medical Center, Dallas, Texas 75390; Division of Endocrinology (E.R.L.), Veterans Affairs Medical Center, Long Beach, Long Beach, California 90822; and Departments of Medicine, Biochemistry, and Pharmacology (E.R.L.), University of California, Irvine, Irvine, California 92697
Correspondence: Address all correspondence and requests for reprints to: Stephen R. Hammes, M.D., Ph.D., University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8857. E-mail: stephen.hammes{at}utsouthwestern.edu; or Ellis R. Levin, M.D., Medical Service (111-I), Long Beach VA Medical Center/University of California-Irvine, 5901 East 7th Street, Long Beach, California 90822. E-mail: ellis.levin{at}va.gov
Rapid effects of steroid hormones result from the actions of specific receptors localized most often to the plasma membrane. Fast-acting membrane-initiated steroid signaling (MISS) 1leads to the modification of existing proteins and cell behaviors. Rapid steroid-triggered signaling through calcium, amine release, and kinase activation also impacts the regulation of gene expression by steroids, sometimes requiring integration with nuclear steroid receptor function. In this and other ways, the integration of all steroid actions in the cell coordinates outcomes such as cell fate, proliferation, differentiation, and migration. The nature of the receptors is of intense interest, and significant data suggest that extranuclear and nuclear steroid receptor pools are the same proteins. Insights regarding the structural determinants for membrane localization and function, as well as the nature of interactions with G proteins and other signaling molecules in confined areas of the membrane, have led to a fuller understanding of how steroid receptors effect rapid actions. Increasingly, the relevance of rapid signaling for the in vivo functions of steroid hormones has been established. Examples include steroid effects on reproductive organ development and function, cardiovascular responsiveness, and cancer biology. However, although great strides have been made, much remains to be understood concerning the integration of extranuclear and nuclear receptor functions to organ biology. In this review, we highlight the significant progress that has been made in these areas.
This article has been cited by other articles:
 |
|
 |
|
  S.-Y. Kim, J. Weiss, M. Tong, M. M. Laronda, E.-J. Lee, and J. L. Jameson Foxl2, a Forkhead Transcription Factor, Modulates Nonclassical Activity of the Estrogen Receptor-{alpha} Endocrinology, November 1, 2009; 150(11): 5085 - 5093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Levin Membrane oestrogen receptor \#945; signalling to cell functions J. Physiol., November 1, 2009; 587(21): 5019 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Catalano, I. Barone, C. Giordano, P. Rizza, H. Qi, G. Gu, R. Malivindi, D. Bonofiglio, and S. Ando Rapid Estradiol/ER{alpha} Signaling Enhances Aromatase Enzymatic Activity in Breast Cancer Cells Mol. Endocrinol., October 1, 2009; 23(10): 1634 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Pandey and D. Picard miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor {alpha} mRNA Mol. Cell. Biol., July 1, 2009; 29(13): 3783 - 3790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Friberg, D.G. J. Larsson, and H. Billig Dominant Role of Nuclear Progesterone Receptor in the Control of Rat Periovulatory Granulosa Cell Apoptosis Biol Reprod, June 1, 2009; 80(6): 1160 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Nott, Y. Huang, X. Li, B. R. Fluharty, X. Qiu, W. V. Welshons, S. Yeh, and M. Muyan Genomic Responses from the Estrogen-responsive Element-dependent Signaling Pathway Mediated by Estrogen Receptor {alpha} Are Required to Elicit Cellular Alterations J. Biol. Chem., May 29, 2009; 284(22): 15277 - 15288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Isensee, L. Meoli, V. Zazzu, C. Nabzdyk, H. Witt, D. Soewarto, K. Effertz, H. Fuchs, V. Gailus-Durner, D. Busch, et al. Expression Pattern of G Protein-Coupled Receptor 30 in LacZ Reporter Mice Endocrinology, April 1, 2009; 150(4): 1722 - 1730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Alam, M. Rajendran, S. Ouyang, S. Veeramani, L. Zhang, and M.-F. Lin A novel role of Shc adaptor proteins in steroid hormone-regulated cancers Endocr. Relat. Cancer, March 1, 2009; 16(1): 1 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Noel, K. L. Keen, D. I. Baumann, E. J. Filardo, and E. Terasawa Involvement of G Protein-Coupled Receptor 30 (GPR30) in Rapid Action of Estrogen in Primate LHRH Neurons Mol. Endocrinol., March 1, 2009; 23(3): 349 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Billon-Gales, C. Fontaine, C. Filipe, V. Douin-Echinard, M.-J. Fouque, G. Flouriot, P. Gourdy, F. Lenfant, H. Laurell, A. Krust, et al. The transactivating function 1 of estrogen receptor {alpha} is dispensable for the vasculoprotective actions of 17{beta}-estradiol PNAS, February 10, 2009; 106(6): 2053 - 2058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Weiss, M. L. Bernhardt, M. M. Laronda, L. A. Hurley, C. Glidewell-Kenney, S. Pillai, M. Tong, K. S. Korach, and J. L. Jameson Estrogen Actions in the Male Reproductive System Involve Estrogen Response Element-Independent Pathways Endocrinology, December 1, 2008; 149(12): 6198 - 6206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Roepke, C. Xue, M. A. Bosch, T. S. Scanlan, M. J. Kelly, and O. K. Ronnekleiv Genes Associated with Membrane-Initiated Signaling of Estrogen and Energy Homeostasis Endocrinology, December 1, 2008; 149(12): 6113 - 6124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Levin Rapid signaling by steroid receptors Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1425 - R1430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kohno, Y. Katsu, T. Iguchi, and L. J. Guillette Jr Novel approaches for the study of vertebrate steroid hormone receptors Integr. Comp. Biol., October 1, 2008; 48(4): 527 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Madak-Erdogan, K. J. Kieser, S. H. Kim, B. Komm, J. A. Katzenellenbogen, and B. S. Katzenellenbogen Nuclear and Extranuclear Pathway Inputs in the Regulation of Global Gene Expression by Estrogen Receptors Mol. Endocrinol., September 1, 2008; 22(9): 2116 - 2127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lague and J. J. Tremblay Antagonistic Effects of Testosterone and the Endocrine Disruptor Mono-(2-Ethylhexyl) Phthalate on INSL3 Transcription in Leydig Cells Endocrinology, September 1, 2008; 149(9): 4688 - 4694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. M. Miller and S. P. Duckles Vascular Actions of Estrogens: Functional Implications Pharmacol. Rev., June 1, 2008; 60(2): 210 - 241. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
