This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: 28/5/575    most recent Final Manuscript Author Manuscript Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lonard, D. M. Articles by O’Malley, B. W. Search for Related Content PubMed PubMed Citation Articles by Lonard, D. M. Articles by O’Malley, B. W.

Nuclear Receptor Coregulators and Human Disease

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030

Correspondence: Address all correspondence and requests for reprints to: Bert W. O’Malley, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030. E-mail: berto{at}bcm.tmc.edu.

Nuclear receptor (NR) coregulators (coactivators and corepressors) are essential elements in regulating nuclear receptor-mediated transcription. In a little more than a decade since their discovery, these proteins have been studied mechanistically and reveal that the regulation of transcription is a highly controlled and complex process. Because of their central role in regulating NR-mediated transcription and in coordinating intercompartmental metabolic processes, disruptions in coregulator biology can lead to pathological states. To date, the extent to which they are involved in human disease has not been widely appreciated. In a complete literature survey, we have identified nearly 300 distinct coregulators, revealing that a great variety of enzymatic and regulatory capabilities exist for NRs to regulate transcription and other cellular events. Here, we substantiate that coregulators are broadly implicated in human pathological states and will be of growing future interest in clinical medicine.

This article has been cited by other articles:

				Y. Li, A. Kovach, K. Suino-Powell, D. Martynowski, and H. E. Xu Structural and Biochemical Basis for the Binding Selectivity of Peroxisome Proliferator-activated Receptor {gamma} to PGC-1{alpha} J. Biol. Chem., July 4, 2008; 283(27): 19132 - 19139. [Abstract] [Full Text] [PDF]

				G. Chaudhuri Nuclear Receptors and Female Reproduction: A Tale of 3 Scientists, Jensen, Gustafsson, and O'Malley Reproductive Sciences, February 1, 2008; 15(2): 110 - 120. [Abstract] [PDF]