Victoria Bolós,
Joaquín Grego-Bessa and
José Luis de la Pompa
Departmento de Inmunología y Oncología, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, E-28049 Madrid, Spain
Correspondence: Address requests for reprints to: José Luis de la Pompa, Departmento de Inmunología y Oncología, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Darwin 3, Campus de Cantoblanco, E-28049 Madrid, Spain. E-mail: jlpompa{at}cnb.uam.es
Notch is an evolutionarily conserved local cell signaling mechanismthat participates in a variety of cellular processes: cell fatespecification, differentiation, proliferation, apoptosis, adhesion,epithelial-mesenchymal transition, migration, and angiogenesis.These processes can be subverted in Notch-mediated pathologicalsituations. In the first part of this review, we will discussthe role of Notch in vertebrate central nervous system development,somitogenesis, cardiovascular and endocrine development, withattention to the mechanisms by which Notch regulates cell fatespecification and patterning in these tissues. In the secondpart, we will review the molecular aspects of Notch-mediatedneoplasias, where Notch can act as an oncogene or as a tumorsuppressor. From all these studies, it becomes evident thatthe outcome of Notch signaling is strictly context-dependentand differences in the strength, timing, cell type, and contextof the signal may affect the final outcome. It is essentialto understand how Notch integrates inputs from other signalingpathways and how specificity is achieved, because this knowledgemay be relevant for future therapeutic applications.
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