Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1544
Correspondence: Address all correspondence and requests for reprints to: Alan D. Attie, Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, Wisconsin 53706-1544. E-mail: attie{at}biochem.wisc.edu
Inbred mouse strains provide genetic diversity comparable tothat of the human population. Like humans, mice have a widerange of diabetes-related phenotypes. The inbred mouse strainsdiffer in the response of their critical physiological functions,such as insulin sensitivity, insulin secretion, ß-cellproliferation and survival, and fuel partitioning, to diet andobesity. Most of the critical genes underlying these differenceshave not been identified, although many loci have been mapped.The dramatic improvements in genomic and bioinformatics resourcesare accelerating the pace of gene discovery. This review describeshow mouse genetics can be used to discover diabetes-relatedgenes, summarizes how the mouse strains differ in their diabetes-relatedphenotypes, and describes several examples of how loci identifiedin the mouse may directly relate to human diabetes.
This article has been cited by other articles:
B. H. Voy and B. J. Aronow Embrace diversity! Systems genetics-enabled discovery of disease networks
Physiol Genomics,
November 6, 2009;
39(3):
169 - 171.
[Full Text][PDF]
R. Muniyappa, H. Chen, R. H. Muzumdar, F. H. Einstein, X. Yan, L. Q. Yue, N. Barzilai, and M. J. Quon Comparison between surrogate indexes of insulin sensitivity/resistance and hyperinsulinemic euglycemic clamp estimates in rats
Am J Physiol Endocrinol Metab,
November 1, 2009;
297(5):
E1023 - E1029.
[Abstract][Full Text][PDF]
M. Fuse, N. Yokoi, M. Shinohara, T. Masuyama, R. Kitazawa, S. Kitazawa, and S. Seino Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat
Physiol Genomics,
September 17, 2008;
35(1):
96 - 105.
[Abstract][Full Text][PDF]
N. Hada, M. Kobayashi, M. Fujiyoshi, A. Ishikawa, M. Kuga, M. Nishimura, S. Ebihara, T. Ohno, and F. Horio Quantitative trait loci for impaired glucose tolerance in nondiabetic SM/J and A/J mice
Physiol Genomics,
September 17, 2008;
35(1):
65 - 74.
[Abstract][Full Text][PDF]
A. M. DeAngelis, G. Heinrich, T. Dai, T. A. Bowman, P. R. Patel, S. J. Lee, E.-G. Hong, D. Y. Jung, A. Assmann, R. N. Kulkarni, et al. Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1: A Link Between Insulin and Lipid Metabolism
Diabetes,
September 1, 2008;
57(9):
2296 - 2303.
[Abstract][Full Text][PDF]
E. D. Berglund, C. Y. Li, G. Poffenberger, J. E. Ayala, P. T. Fueger, S. E. Willis, M. M. Jewell, A. C. Powers, and D. H. Wasserman Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains
Diabetes,
July 1, 2008;
57(7):
1790 - 1799.
[Abstract][Full Text][PDF]
C. Schmidt, N. P. Gonzaludo, S. Strunk, S. Dahm, J. Schuchhardt, F. Kleinjung, S. Wuschke, H.-G. Joost, and H. Al-Hasani A meta-analysis of QTL for diabetes-related traits in rodents
Physiol Genomics,
June 1, 2008;
34(1):
42 - 53.
[Abstract][Full Text][PDF]
A. T. Oler and A. D. Attie A rapid, microplate SNP genotype assay for the leptinob allele
J. Lipid Res.,
May 1, 2008;
49(5):
1126 - 1129.
[Abstract][Full Text][PDF]
S. Lee, R. Muniyappa, X. Yan, H. Chen, L. Q. Yue, E.-G. Hong, J. K. Kim, and M. J. Quon Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice
Am J Physiol Endocrinol Metab,
February 1, 2008;
294(2):
E261 - E270.
[Abstract][Full Text][PDF]
B. Aigner, B. Rathkolb, N. Herbach, M. H. de Angelis, R. Wanke, and E. Wolf Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects
Am J Physiol Endocrinol Metab,
February 1, 2008;
294(2):
E232 - E240.
[Abstract][Full Text][PDF]
