Katrien Janssens,
Peter ten Dijke,
Sophie Janssens1 and
Wim Van Hul1
Department of Medical Genetics (K.J., W.V.H.), University of Antwerp, 2610 Antwerp, Belgium; Department of Molecular Cell Biology (P.t.D.), Leids Universitair Medisch Centrum, 2333 AL Leiden, The Netherlands; and Department of Biochemistry (S.J.), University of Lausanne, 1066 Epalinges-Lausanne, Switzerland
Correspondence: Address all correspondence and requests for reprints to: Professor Dr. Wim Van Hul, Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, Building T6, Universiteitsplein 1, 2610 Antwerp, Belgium. E-mail: wim.vanhul{at}ua.ac.be
TGF-ß1 is a ubiquitous growth factor that is implicatedin the control of proliferation, migration, differentiation,and survival of many different cell types. It influences suchdiverse processes as embryogenesis, angiogenesis, inflammation,and wound healing. In skeletal tissue, TGF-ß1 playsa major role in development and maintenance, affecting bothcartilage and bone metabolism, the latter being the subjectof this review. Because it affects both cells of the osteoblastand osteoclast lineage, TGF-ß1 is one of the mostimportant factors in the bone environment, helping to retainthe balance between the dynamic processes of bone resorptionand bone formation. Many seemingly contradictory reports havebeen published on the exact functioning of TGF-ß1in the bone milieu. This review provides an overall pictureof the bone-specific actions of TGF-ß1 and reconcilesexperimental discrepancies that have been reported for thismultifunctional cytokine.
This article has been cited by other articles:
H. Flanagan-Steet, C. Sias, and R. Steet Altered Chondrocyte Differentiation and Extracellular Matrix Homeostasis in a Zebrafish Model for Mucolipidosis II
Am. J. Pathol.,
November 1, 2009;
175(5):
2063 - 2075.
[Abstract][Full Text][PDF]
N. Houde, E. Chamoux, M. Bisson, and S. Roux Transforming Growth Factor-{beta}1 (TGF-{beta}1) Induces Human Osteoclast Apoptosis by Up-regulating Bim
J. Biol. Chem.,
August 28, 2009;
284(35):
23397 - 23404.
[Abstract][Full Text][PDF]
P. Atsawasuwan, Y. Mochida, M. Katafuchi, M. Kaku, K. S. K. Fong, K. Csiszar, and M. Yamauchi Lysyl Oxidase Binds Transforming Growth Factor-{beta} and Regulates Its Signaling via Amine Oxidase Activity
J. Biol. Chem.,
December 5, 2008;
283(49):
34229 - 34240.
[Abstract][Full Text][PDF]
E. O. Oviedo-Rondon, J. Small, M. J. Wineland, V. L. Christensen, J. L. Grimes, S. V. L. Funderburk, D. T. Ort, and K. M. Mann Effects of Incubator Temperature and Oxygen Concentration During the Plateau Stage of Oxygen Consumption on Turkey Embryo Long Bone Development
Poult. Sci.,
August 1, 2008;
87(8):
1484 - 1492.
[Abstract][Full Text][PDF]
B. A Teicher, J. M Yingling, and J. M McPherson TGF{beta} Blockade as Anticancer Therapy
Am. Assoc. Cancer Res. Educ. Book,
April 12, 2008;
2008(1):
71 - 81.
[Abstract][Full Text][PDF]
L. A Kingsley, P. G J Fournier, J. M Chirgwin, and T. A Guise Molecular Biology of Bone Metastasis
Am. Assoc. Cancer Res. Educ. Book,
April 12, 2008;
2008(1):
443 - 457.
[Abstract][Full Text][PDF]
C. Dufour, X. Holy, and P. J. Marie Transforming growth factor-{beta} prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling
Am J Physiol Endocrinol Metab,
April 1, 2008;
294(4):
E794 - E801.
[Abstract][Full Text][PDF]
B. A. Teicher Transforming Growth Factor-{beta} and the Immune Response to Malignant Disease
Clin. Cancer Res.,
November 1, 2007;
13(21):
6247 - 6251.
[Abstract][Full Text][PDF]
S. K. Sze, D. P. V. de Kleijn, R. C. Lai, E. Khia Way Tan, H. Zhao, K. S. Yeo, T. Y. Low, Q. Lian, C. N. Lee, W. Mitchell, et al. Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells
Mol. Cell. Proteomics,
October 1, 2007;
6(10):
1680 - 1689.
[Abstract][Full Text][PDF]
L. A. Kingsley, P. G.J. Fournier, J. M. Chirgwin, and T. A. Guise Molecular Biology of Bone Metastasis
Mol. Cancer Ther.,
October 1, 2007;
6(10):
2609 - 2617.
[Abstract][Full Text][PDF]
M. Thys, I. Schrauwen, K. Vanderstraeten, K. Janssens, N. Dieltjens, K. Van Den Bogaert, E. Fransen, W. Chen, M. Ealy, M. Claustres, et al. The coding polymorphism T263I in TGF-{beta}1 is associated with otosclerosis in two independent populations
Hum. Mol. Genet.,
September 1, 2007;
16(17):
2021 - 2030.
[Abstract][Full Text][PDF]
M. Eijken, S. Swagemakers, M. Koedam, C. Steenbergen, P. Derkx, A. G. Uitterlinden, P. J. van der Spek, J. A. Visser, F. H. de Jong, H. A. P. Pols, et al. The activin A-follistatin system: potent regulator of human extracellular matrix mineralization
FASEB J,
September 1, 2007;
21(11):
2949 - 2960.
[Abstract][Full Text][PDF]
X. Tan, T. Weng, J. Zhang, J. Wang, W. Li, H. Wan, Y. Lan, X. Cheng, N. Hou, H. Liu, et al. Smad4 is required for maintaining normal murine postnatal bone homeostasis
J. Cell Sci.,
July 1, 2007;
120(13):
2162 - 2170.
[Abstract][Full Text][PDF]
C. J. Xian Roles of Epidermal Growth Factor Family in the Regulation of Postnatal Somatic Growth
Endocr. Rev.,
May 1, 2007;
28(3):
284 - 296.
[Abstract][Full Text][PDF]
R. J. LeClair, T. Durmus, Q. Wang, P. Pyagay, A. Terzic, and V. Lindner Cthrc1 Is a Novel Inhibitor of Transforming Growth Factor-{beta} Signaling and Neointimal Lesion Formation
Circ. Res.,
March 30, 2007;
100(6):
826 - 833.
[Abstract][Full Text][PDF]
A. Menoret, L. M. Myers, S.-J. Lee, R. S. Mittler, R. J. Rossi, and A. T. Vella TGFbeta Protein Processing and Activity through TCR Triggering of Primary CD8+ T Regulatory Cells
J. Immunol.,
November 1, 2006;
177(9):
6091 - 6097.
[Abstract][Full Text][PDF]
D. L. Fleenor, A. R. Shepard, P. E. Hellberg, N. Jacobson, I.-H. Pang, and A. F. Clark TGF{beta}2-Induced Changes in Human Trabecular Meshwork: Implications for Intraocular Pressure
Invest. Ophthalmol. Vis. Sci.,
January 1, 2006;
47(1):
226 - 234.
[Abstract][Full Text][PDF]
K Janssens, F Vanhoenacker, M Bonduelle, L Verbruggen, L Van Maldergem, S Ralston, N Guanabens, N Migone, S Wientroub, M T Divizia, et al. Camurati-Engelmann disease: review of the clinical, radiological, and molecular data of 24 families and implications for diagnosis and treatment
J. Med. Genet.,
January 1, 2006;
43(1):
1 - 11.
[Abstract][Full Text][PDF]
T. Ichijo, A. Voutetakis, A. P. Cotrim, N. Bhattachryya, M. Fujii, G. P. Chrousos, and T. Kino The Smad6-Histone Deacetylase 3 Complex Silences the Transcriptional Activity of the Glucocorticoid Receptor: POTENTIAL CLINICAL IMPLICATIONS
J. Biol. Chem.,
December 23, 2005;
280(51):
42067 - 42077.
[Abstract][Full Text][PDF]
S. L. Ferrari, E. Seeman, and G. J. Strewler Clinical and Basic Research Papers - October 2005 Selections
IBMS BoneKEy,
November 1, 2005;
2(11):
1 - 6.
[Full Text][PDF]
