The Search for Safer Glucocorticoid Receptor Ligands
Jonathan Rosen and
Jeffrey N. Miner
Department of Molecular and Cell Biology, Ligand Pharmaceuticals, San Diego, California 92121
Correspondence: Address all correspondence and requests for reprints to: Jeffrey N. Miner, Department of Molecular and Cell Biology, Ligand Pharmaceuticals, 10275 Science Center Drive, San Diego, California 92121. E-mail: jminer{at}ligand.com
Steroidal glucocorticoids are commonly used due to their powerfulantiinflammatory activity. However, despite their excellentefficacy, severe side effects frequently limit the use of thesedrugs. The search for novel glucocorticoids with reduced sideeffects has been intensified by the discovery of new moleculardetails regarding the function of the glucocorticoid receptor.These new insights may pave the way for novel, safer therapiesthat retain the efficacy of currently prescribed steroids.
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