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Endocrine Reviews 25 (4): 581-611
Copyright © 2004 by The Endocrine Society

Vascular Endothelial Growth Factor: Basic Science and Clinical Progress

Napoleone Ferrara

Department of Molecular Oncology, Genentech, Inc., South San Francisco, California 94080

Correspondence: Address all correspondence and requests for reprints to: Napoleone Ferrara, M.D., Department of Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080. E-mail: nf{at}gene.com

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major inducer of VEGF gene transcription. The tyrosine kinases Flt-1 (VEGFR-1) and Flk-1/KDR (VEGFR-2) are high-affinity VEGF receptors. The role of VEGF in developmental angiogenesis is emphasized by the finding that loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF is critical also for reproductive and bone angiogenesis. Substantial evidence also implicates VEGF as a mediator of pathological angiogenesis. In situ hybridization studies demonstrate expression of VEGF mRNA in the majority of human tumors. Anti-VEGF monoclonal antibodies and other VEGF inhibitors block the growth of several tumor cell lines in nude mice. Clinical trials with various VEGF inhibitors in a variety of malignancies are ongoing. Very recently, an anti-VEGF monoclonal antibody (bevacizumab; Avastin) has been approved by the Food and Drug Administration as a first-line treatment for metastatic colorectal cancer in combination with chemotherapy. Furthermore, VEGF is implicated in intraocular neovascularization associated with diabetic retinopathy and age-related macular degeneration.




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[Abstract] [Full Text] [PDF]

Home page
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Home page
 J. Virol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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J. Biol. Chem., September 21, 2007; 282(38): 28045 - 28056.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
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[Abstract] [Full Text] [PDF]

Home page
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Thorax, August 1, 2007; 62(8): 718 - 722.
[Abstract] [Full Text] [PDF]

Home page
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Am J Physiol Renal Physiol, August 1, 2007; 293(2): F565 - F574.
[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Full Text] [PDF]

Home page
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Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G5 - G18.
[Abstract] [Full Text] [PDF]

Home page
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Clin. Cancer Res., July 1, 2007; 13(13): 3762 - 3764.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
C. H. Gravholt, H. E. Poulsen, P. Ott, J. S. Christiansen, and H. Vilstrup
Quantitative liver functions in Turner syndrome with and without hormone replacement therapy
Eur. J. Endocrinol., June 1, 2007; 156(6): 679 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
D. Ribatti, M. T. Conconi, and G. G. Nussdorfer
Nonclassic Endogenous Novel Regulators of Angiogenesis
Pharmacol. Rev., June 1, 2007; 59(2): 185 - 205.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Wolnicka-Glubisz, J. Damsker, S. Constant, S. Corn, E. De Fabo, and F. Noonan
Deficient inflammatory response to UV radiation in neonatal mice
J. Leukoc. Biol., June 1, 2007; 81(6): 1352 - 1361.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Ophthalmol.Home page
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Effect of systemic bevacizumab therapy on retinal pigment epithelial detachment
Br. J. Ophthalmol., June 1, 2007; 91(6): 785 - 789.
[Abstract] [Full Text] [PDF]

Home page
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A. A. Khorana, S. A. Ahrendt, C. K. Ryan, C. W. Francis, R. H. Hruban, Y. C. Hu, G. Hostetter, J. Harvey, and M. B. Taubman
Tissue Factor Expression, Angiogenesis, and Thrombosis in Pancreatic Cancer
Clin. Cancer Res., May 15, 2007; 13(10): 2870 - 2875.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
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Estrogen-Induced Activation of Hypoxia-Inducible Factor-1{alpha}, Vascular Endothelial Growth Factor Expression, and Edema in the Uterus Are Mediated by the Phosphatidylinositol 3-Kinase/Akt Pathway
Endocrinology, May 1, 2007; 148(5): 2363 - 2374.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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Phosphorylation of Tyrosine 801 of Vascular Endothelial Growth Factor Receptor-2 Is Necessary for Akt-dependent Endothelial Nitric-oxide Synthase Activation and Nitric Oxide Release from Endothelial Cells
J. Biol. Chem., April 6, 2007; 282(14): 10660 - 10669.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
U. U. Inan, B. Avci, T. Kusbeci, B. Kaderli, R. Avci, and S. G. Temel
Preclinical Safety Evaluation of Intravitreal Injection of Full-Length Humanized Vascular Endothelial Growth Factor Antibody in Rabbit Eyes
Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1773 - 1781.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Nicoli, D. Ribatti, F. Cotelli, and M. Presta
Mammalian Tumor Xenografts Induce Neovascularization in Zebrafish Embryos
Cancer Res., April 1, 2007; 67(7): 2927 - 2931.
[Abstract] [Full Text] [PDF]

Home page
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The Potential of Antiangiogenic Therapy in Non-Small Cell Lung Cancer
Clin. Cancer Res., April 1, 2007; 13(7): 1961 - 1970.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
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Ann. Pharmacother., April 1, 2007; 41(4): 707 - 710.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Laramee, C. Chabot, M. Cloutier, R. Stenne, M. Holgado-Madruga, A. J. Wong, and I. Royal
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J. Biol. Chem., March 16, 2007; 282(11): 7758 - 7769.
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Home page
 J Am Coll CardiolHome page
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J. Am. Coll. Cardiol., March 13, 2007; 49(10): 1015 - 1026.
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Home page
 J. Gen. Virol.Home page
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