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Endocrine Reviews 25 (3): 341-373
Copyright © 2004 by The Endocrine Society

Molecular Cues to Implantation

S. K. Dey, H. Lim, Sanjoy K. Das, Jeff Reese, B. C. Paria, Takiko Daikoku and Haibin Wang

Departments of Pediatrics (S.K.De., S.K.Da., J.R., B.C.P., T.D., H.W.), Cell and Developmental Biology, and Pharmacology (S.K.De.), Vanderbilt University Medical Center, Nashville, Tennessee 37232; and Departments of Obstetrics and Gynecology, and Cell Biology and Physiology (H.L.), Washington University School of Medicine, St. Louis, Missouri 63110

Correspondence: Address all correspondence and requests for reprints to: S. K. Dey, Ph.D., Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232. E-mail: sk.dey{at}vanderbilt.edu.

Successful implantation is the result of reciprocal interactions between the implantation-competent blastocyst and receptive uterus. Although various cellular aspects and molecular pathways of this dialogue have been identified, a comprehensive understanding of the implantation process is still missing. The receptive state of the uterus, which lasts for a limited period, is defined as the time when the uterine environment is conducive to blastocyst acceptance and implantation. A better understanding of the molecular signals that regulate uterine receptivity and implantation competency of the blastocyst is of clinical relevance because unraveling the nature of these signals may lead to strategies to correct implantation failure and improve pregnancy rates. Gene expression studies and genetically engineered mouse models have provided valuable clues to the implantation process with respect to specific growth factors, cytokines, lipid mediators, adhesion molecules, and transcription factors. However, a staggering amount of information from microarray experiments is also being generated at a rapid pace. If properly annotated and explored, this information will expand our knowledge regarding yet-to-be-identified unique, complementary, and/or redundant molecular pathways in implantation. It is hoped that the forthcoming information will generate new ideas and concepts for a process that is essential for maintaining procreation and solving major reproductive health issues in women.




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