George Whipple Laboratory for Cancer Research, Departments of Pathology, Urology, and Radiation Oncology, and the Cancer Center, University of Rochester, Rochester, New York 14642
Correspondence: Address all correspondence and requests for reprints to: Chawnshang Chang, Ph.D., Department of Pathology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642. E-mail: chang{at}urmc.rochester.edu
The normal development and maintenance of the prostate is dependenton androgen acting through the androgen receptor (AR). AR remainsimportant in the development and progression of prostate cancer.AR expression is maintained throughout prostate cancer progression,and the majority of androgen-independent or hormone refractoryprostate cancers express AR. Mutation of AR, especially mutationsthat result in a relaxation of AR ligand specificity, may contributeto the progression of prostate cancer and the failure of endocrinetherapy by allowing AR transcriptional activation in responseto antiandrogens or other endogenous hormones. Similarly, alterationsin the relative expression of AR coregulators have been foundto occur with prostate cancer progression and may contributeto differences in AR ligand specificity or transcriptional activity.Prostate cancer progression is also associated with increasedgrowth factor production and an altered response to growth factorsby prostate cancer cells. The kinase signal transduction cascadesinitiated by mitogenic growth factors modulate the transcriptionalactivity of AR and the interaction between AR and AR coactivators.The inhibition of AR activity through mechanisms in additionto androgen ablation, such as modulation of signal transductionpathways, may delay prostate cancer progression.
This article has been cited by other articles:
H.-Z. Sun, T.-W. Yang, W.-J. Zang, and S.-F. Wu Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway
J. Endocrinol.,
March 1, 2010;
204(3):
311 - 318.
[Abstract][Full Text][PDF]
M. A. Titus, J.-a. Tan, C. W. Gregory, O. H. Ford, R. R. Subramanian, H. Fu, E. M. Wilson, J. L. Mohler, and F. S. French 14-3-3{eta} Amplifies Androgen Receptor Actions in Prostate Cancer
Clin. Cancer Res.,
December 15, 2009;
15(24):
7571 - 7581.
[Abstract][Full Text][PDF]
F. Tang, J. Kokontis, Y. Lin, S. Liao, A. Lin, and J. Xiang Androgen via p21 Inhibits Tumor Necrosis Factor {alpha}-induced JNK Activation and Apoptosis
J. Biol. Chem.,
November 20, 2009;
284(47):
32353 - 32358.
[Abstract][Full Text][PDF]
S. Rajender, K. Vijayalakshmi, S. Pooja, S. Madhavi, S. F. D. Paul, V. Vettriselvi, S. Shroff, L. Singh, and K. Thangaraj Longer (TA)n Repeat but Not A49T and V89L Polymorphisms in SRD5A2 Gene May Confer Prostate Cancer Risk in South Indian Men
J Androl,
November 1, 2009;
30(6):
703 - 710.
[Abstract][Full Text][PDF]
K. K. Waltering, M. A. Helenius, B. Sahu, V. Manni, M. J. Linja, O. A. Janne, and T. Visakorpi Increased Expression of Androgen Receptor Sensitizes Prostate Cancer Cells to Low Levels of Androgens
Cancer Res.,
October 15, 2009;
69(20):
8141 - 8149.
[Abstract][Full Text][PDF]
S. K. Baniwal, O. Khalid, D. Sir, G. Buchanan, G. A. Coetzee, and B. Frenkel Repression of Runx2 by Androgen Receptor (AR) in Osteoblasts and Prostate Cancer Cells: AR Binds Runx2 and Abrogates Its Recruitment to DNA
Mol. Endocrinol.,
August 1, 2009;
23(8):
1203 - 1214.
[Abstract][Full Text][PDF]
S. D. Stan and S. V. Singh Transcriptional Repression and Inhibition of Nuclear Translocation of Androgen Receptor by Diallyl Trisulfide in Human Prostate Cancer Cells
Clin. Cancer Res.,
August 1, 2009;
15(15):
4895 - 4903.
[Abstract][Full Text][PDF]
H. Makkonen, M. Kauhanen, V. Paakinaho, T. Jaaskelainen, and J. J. Palvimo Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers
Nucleic Acids Res.,
July 1, 2009;
37(12):
4135 - 4148.
[Abstract][Full Text][PDF]
V. Bhatia, R. V. Mula, N. L. Weigel, and M. Falzon Parathyroid Hormone-Related Protein Regulates Cell Survival Pathways via Integrin {alpha}6{beta}4-Mediated Activation of Phosphatidylinositol 3-Kinase/Akt Signaling
Mol. Cancer Res.,
July 1, 2009;
7(7):
1119 - 1131.
[Abstract][Full Text][PDF]
V. Lakshmikanthan, L. Zou, J. I. Kim, A. Michal, Z. Nie, N. C. Messias, J. L. Benovic, and Y. Daaka Identification of {beta}Arrestin2 as a corepressor of androgen receptor signaling in prostate cancer
PNAS,
June 9, 2009;
106(23):
9379 - 9384.
[Abstract][Full Text][PDF]
M. Lupien and M. Brown Cistromics of hormone-dependent cancer
Endocr. Relat. Cancer,
June 1, 2009;
16(2):
381 - 389.
[Abstract][Full Text][PDF]
K. W. Rahman, S. Banerjee, S. Ali, A. Ahmad, Z. Wang, D. Kong, and W. A. Sakr 3,3'-Diindolylmethane Enhances Taxotere-Induced Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-regulation
Cancer Res.,
May 15, 2009;
69(10):
4468 - 4475.
[Abstract][Full Text][PDF]
J. X. Zou, L. Guo, A. S. Revenko, C. G. Tepper, A. T. Gemo, H.-J. Kung, and H.-W. Chen Androgen-Induced Coactivator ANCCA Mediates Specific Androgen Receptor Signaling in Prostate Cancer
Cancer Res.,
April 15, 2009;
69(8):
3339 - 3346.
[Abstract][Full Text][PDF]
K. Wu, S. Katiyar, A. Witkiewicz, A. Li, P. McCue, L.-N. Song, L. Tian, M. Jin, and R. G. Pestell The Cell Fate Determination Factor Dachshund Inhibits Androgen Receptor Signaling and Prostate Cancer Cellular Growth
Cancer Res.,
April 15, 2009;
69(8):
3347 - 3355.
[Abstract][Full Text][PDF]
S. Altuwaijri, K.-H. Chuang, K.-P. Lai, J.-J. Lai, H.-Y. Lin, F. M. Young, A. Bottaro, M.-Y. Tsai, W.-P. Zeng, H.-C. Chang, et al. Susceptibility to Autoimmunity and B Cell Resistance to Apoptosis in Mice Lacking Androgen Receptor in B Cells
Mol. Endocrinol.,
April 1, 2009;
23(4):
444 - 453.
[Abstract][Full Text][PDF]
J.-C. Pignon, B. Koopmansch, G. Nolens, L. Delacroix, D. Waltregny, and R. Winkler Androgen Receptor Controls EGFR and ERBB2 Gene Expression at Different Levels in Prostate Cancer Cell Lines
Cancer Res.,
April 1, 2009;
69(7):
2941 - 2949.
[Abstract][Full Text][PDF]
Z. Guo, X. Yang, F. Sun, R. Jiang, D. E. Linn, H. Chen, H. Chen, X. Kong, J. Melamed, C. G. Tepper, et al. A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion-Resistant Growth
Cancer Res.,
March 15, 2009;
69(6):
2305 - 2313.
[Abstract][Full Text][PDF]
S. A Boorjian, H. V Heemers, I. Frank, S. A Farmer, L. J Schmidt, T. J Sebo, and D. J Tindall Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder
Endocr. Relat. Cancer,
March 1, 2009;
16(1):
123 - 137.
[Abstract][Full Text][PDF]
R. Hu, T. A. Dunn, S. Wei, S. Isharwal, R. W. Veltri, E. Humphreys, M. Han, A. W. Partin, R. L. Vessella, W. B. Isaacs, et al. Ligand-Independent Androgen Receptor Variants Derived from Splicing of Cryptic Exons Signify Hormone-Refractory Prostate Cancer
Cancer Res.,
January 1, 2009;
69(1):
16 - 22.
[Abstract][Full Text][PDF]
H. B. Pearson, T. J. Phesse, and A. R. Clarke K-ras and Wnt Signaling Synergize to Accelerate Prostate Tumorigenesis in the Mouse
Cancer Res.,
January 1, 2009;
69(1):
94 - 101.
[Abstract][Full Text][PDF]
M.-L. Zhu and N. Kyprianou Androgen receptor and growth factor signaling cross-talk in prostate cancer cells
Endocr. Relat. Cancer,
December 1, 2008;
15(4):
841 - 849.
[Abstract][Full Text][PDF]
Y. J. Arnoldussen, P. I. Lorenzo, M. E. Pretorius, H. Waehre, B. Risberg, G. M. Maelandsmo, H. E. Danielsen, and F. Saatcioglu The Mitogen-Activated Protein Kinase Phosphatase Vaccinia H1-Related Protein Inhibits Apoptosis in Prostate Cancer Cells and Is Overexpressed in Prostate Cancer
Cancer Res.,
November 15, 2008;
68(22):
9255 - 9264.
[Abstract][Full Text][PDF]
T. Kanda, R. Steele, R. Ray, and R. B. Ray Hepatitis C Virus Core Protein Augments Androgen Receptor-Mediated Signaling
J. Virol.,
November 15, 2008;
82(22):
11066 - 11072.
[Abstract][Full Text][PDF]
T. S. Udayakumar, P. Hachem, M. M. Ahmed, S. Agrawal, and A. Pollack Antisense MDM2 Enhances E2F1-Induced Apoptosis and the Combination Sensitizes Androgen-Dependent and Androgen-Independent Prostate Cancer Cells to Radiation
Mol. Cancer Res.,
November 1, 2008;
6(11):
1742 - 1754.
[Abstract][Full Text][PDF]
Y. Li, Z. Wang, D. Kong, R. Li, S. H. Sarkar, and F. H. Sarkar Regulation of Akt/FOXO3a/GSK-3{beta}/AR Signaling Network by Isoflavone in Prostate Cancer Cells
J. Biol. Chem.,
October 10, 2008;
283(41):
27707 - 27716.
[Abstract][Full Text][PDF]
K. Song, H. Wang, T. L. Krebs, S.-J. Kim, and D. Danielpour Androgenic Control of Transforming Growth Factor-{beta} Signaling in Prostate Epithelial Cells through Transcriptional Suppression of Transforming Growth Factor-{beta} Receptor II
Cancer Res.,
October 1, 2008;
68(19):
8173 - 8182.
[Abstract][Full Text][PDF]
S. Basak, D. Pookot, E. J. Noonan, and R. Dahiya Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function
Mol. Cancer Ther.,
October 1, 2008;
7(10):
3195 - 3202.
[Abstract][Full Text][PDF]
N. Sharifi, E. M. Hurt, S. B. Thomas, and W. L. Farrar Effects of Manganese Superoxide Dismutase Silencing on Androgen Receptor Function and Gene Regulation: Implications for Castration-Resistant Prostate Cancer
Clin. Cancer Res.,
October 1, 2008;
14(19):
6073 - 6080.
[Abstract][Full Text][PDF]
L. Guo, D. Zhong, S. Lau, X. Liu, X.-Y. Dong, X. Sun, V. W. Yang, P. M. Vertino, C. S. Moreno, V. Varma, et al. Sox7 Is an Independent Checkpoint for {beta}-Catenin Function in Prostate and Colon Epithelial Cells
Mol. Cancer Res.,
September 1, 2008;
6(9):
1421 - 1430.
[Abstract][Full Text][PDF]
Y. Dai, D. Ngo, J. Jacob, L. W. Forman, and D. V. Faller Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes
Carcinogenesis,
September 1, 2008;
29(9):
1725 - 1733.
[Abstract][Full Text][PDF]
W.-C. Huang, J. J. Havel, H. E. Zhau, W. P. Qian, H.-W. Lue, C.-Y. Chu, T. Nomura, and L. W.K. Chung {beta}2-Microglobulin Signaling Blockade Inhibited Androgen Receptor Axis and Caused Apoptosis in Human Prostate Cancer Cells
Clin. Cancer Res.,
September 1, 2008;
14(17):
5341 - 5347.
[Abstract][Full Text][PDF]
Y. Niu, S. Altuwaijri, K.-P. Lai, C.-T. Wu, W. A. Ricke, E. M. Messing, J. Yao, S. Yeh, and C. Chang Androgen receptor is a tumor suppressor and proliferator in prostate cancer
PNAS,
August 26, 2008;
105(34):
12182 - 12187.
[Abstract][Full Text][PDF]
Y. Niu, S. Altuwaijri, S. Yeh, K.-P. Lai, S. Yu, K.-H. Chuang, S.-P. Huang, H. Lardy, and C. Chang Targeting the stromal androgen receptor in primary prostate tumors at earlier stages
PNAS,
August 26, 2008;
105(34):
12188 - 12193.
[Abstract][Full Text][PDF]
F.-M. Lin, C.-H. Tsai, Y.-C. Yang, W.-C. Tu, L.-R. Chen, Y.-S. Liang, S.-Y. Wang, L.-F. Shyur, S.-C. Chien, T.-L. Cha, et al. A Novel Diterpene Suppresses CWR22Rv1 Tumor Growth In vivo through Antiproliferation and Proapoptosis
Cancer Res.,
August 15, 2008;
68(16):
6634 - 6642.
[Abstract][Full Text][PDF]
R. J. Jin, Y. Lho, L. Connelly, Y. Wang, X. Yu, L. Saint Jean, T. C. Case, K. Ellwood-Yen, C. L. Sawyers, N. A. Bhowmick, et al. The Nuclear Factor-{kappa}B Pathway Controls the Progression of Prostate Cancer to Androgen-Independent Growth
Cancer Res.,
August 15, 2008;
68(16):
6762 - 6769.
[Abstract][Full Text][PDF]
J. Hoon Lee, H. Gong, S. Khadem, Y. Lu, X. Gao, S. Li, J. Zhang, and W. Xie Androgen Deprivation by Activating the Liver X Receptor
Endocrinology,
August 1, 2008;
149(8):
3778 - 3788.
[Abstract][Full Text][PDF]
N. Sharifi, W. L. Dahut, and W. D. Figg The Genetics of Castration-Resistant Prostate Cancer: What Can the Germline Tell Us?
Clin. Cancer Res.,
August 1, 2008;
14(15):
4691 - 4693.
[Abstract][Full Text][PDF]
S. M. Dehm, L. J. Schmidt, H. V. Heemers, R. L. Vessella, and D. J. Tindall Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy Resistance
Cancer Res.,
July 1, 2008;
68(13):
5469 - 5477.
[Abstract][Full Text][PDF]
A. Yemelyanov, J. Czwornog, L. Gera, S. Joshi, R. T. Chatterton Jr., and I. Budunova Novel Steroid Receptor Phyto-Modulator Compound A Inhibits Growth and Survival of Prostate Cancer Cells
Cancer Res.,
June 15, 2008;
68(12):
4763 - 4773.
[Abstract][Full Text][PDF]
S. T. Page, J. K. Amory, and W. J. Bremner Advances in Male Contraception
Endocr. Rev.,
June 1, 2008;
29(4):
465 - 493.
[Abstract][Full Text][PDF]
L. C. Shank, J. B. Kelley, D. Gioeli, C.-S. Yang, A. Spencer, L. A. Allison, and B. M. Paschal Activation of the DNA-dependent Protein Kinase Stimulates Nuclear Export of the Androgen Receptor in Vitro
J. Biol. Chem.,
April 18, 2008;
283(16):
10568 - 10580.
[Abstract][Full Text][PDF]
M. Mimeault, P. P. Mehta, R. Hauke, and S. K. Batra Functions of Normal and Malignant Prostatic Stem/Progenitor Cells in Tissue Regeneration and Cancer Progression and Novel Targeting Therapies
Endocr. Rev.,
April 1, 2008;
29(2):
234 - 252.
[Abstract][Full Text][PDF]
M. L. Cutress, H. C. Whitaker, I. G. Mills, M. Stewart, and D. E. Neal Structural basis for the nuclear import of the human androgen receptor
J. Cell Sci.,
April 1, 2008;
121(7):
957 - 968.
[Abstract][Full Text][PDF]
L. S. Lyons, S. Rao, W. Balkan, J. Faysal, C. A. Maiorino, and K. L. Burnstein Ligand-Independent Activation of Androgen Receptors by Rho GTPase Signaling in Prostate Cancer
Mol. Endocrinol.,
March 1, 2008;
22(3):
597 - 608.
[Abstract][Full Text][PDF]
D. E. Frigo and D. P. McDonnell Differential effects of prostate cancer therapeutics on neuroendocrine transdifferentiation
Mol. Cancer Ther.,
March 1, 2008;
7(3):
659 - 669.
[Abstract][Full Text][PDF]
J. R. Sterbis, C. Gao, B. Furusato, Y. Chen, S. Shaheduzzaman, L. Ravindranath, D. J. Osborn, I. L. Rosner, A. Dobi, D. G. McLeod, et al. Higher Expression of the Androgen-Regulated Gene PSA/HK3 mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
Clin. Cancer Res.,
February 1, 2008;
14(3):
758 - 763.
[Abstract][Full Text][PDF]
J. H. Suh, E.-Y. Gong, J. B. Kim, I.-K. Lee, H.-S. Choi, and K. Lee Sterol Regulatory Element-Binding Protein-1c Represses the Transactivation of Androgen Receptor and Androgen-Dependent Growth of Prostatic Cells
Mol. Cancer Res.,
February 1, 2008;
6(2):
314 - 324.
[Abstract][Full Text][PDF]
S. F. Shariat, D. J. Lamb, R. G. Iyengar, C. G. Roehrborn, and K. M. Slawin Herbal/Hormonal Dietary Supplement Possibly Associated with Prostate Cancer Progression
Clin. Cancer Res.,
January 15, 2008;
14(2):
607 - 611.
[Abstract][Full Text][PDF]
S.-H. Tan, A. Dagvadorj, F. Shen, L. Gu, Z. Liao, J. Abdulghani, Y. Zhang, E. P. Gelmann, T. Zellweger, Z. Culig, et al. Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer Cells
Cancer Res.,
January 1, 2008;
68(1):
236 - 248.
[Abstract][Full Text][PDF]
J. H. Suh, M. Shong, H.-S. Choi, and K. Lee CR6-Interacting Factor 1 Represses the Transactivation of Androgen Receptor by Direct Interaction
Mol. Endocrinol.,
January 1, 2008;
22(1):
33 - 46.
[Abstract][Full Text][PDF]
S. M. Dehm and D. J. Tindall Androgen Receptor Structural and Functional Elements: Role and Regulation in Prostate Cancer
Mol. Endocrinol.,
December 1, 2007;
21(12):
2855 - 2863.
[Abstract][Full Text][PDF]
F.-M. Lin, L.-R. Chen, E.-H. Lin, F.-C. Ke, H.-Y. Chen, M.-J. Tsai, and P.-W. Hsiao Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells
Carcinogenesis,
December 1, 2007;
28(12):
2521 - 2529.
[Abstract][Full Text][PDF]
J. T. Read, M. Rahmani, S. Boroomand, S. Allahverdian, B. M. McManus, and P. S. Rennie Androgen Receptor Regulation of the Versican Gene through an Androgen Response Element in the Proximal Promoter
J. Biol. Chem.,
November 2, 2007;
282(44):
31954 - 31963.
[Abstract][Full Text][PDF]
H. Zong, Y. Chi, Y. Wang, Y. Yang, L. Zhang, H. Chen, J. Jiang, Z. Li, Y. Hong, H. Wang, et al. Cyclin D3/CDK11p58 Complex Is Involved in the Repression of Androgen Receptor
Mol. Cell. Biol.,
October 15, 2007;
27(20):
7125 - 7142.
[Abstract][Full Text][PDF]
S. M. Dehm, K. M. Regan, L. J. Schmidt, and D. J. Tindall Selective Role of an NH2-Terminal WxxLF Motif for Aberrant Androgen Receptor Activation in Androgen Depletion Independent Prostate Cancer Cells
Cancer Res.,
October 15, 2007;
67(20):
10067 - 10077.
[Abstract][Full Text][PDF]
E. Estebanez-Perpina, L. A. Arnold, P. Nguyen, E. D. Rodrigues, E. Mar, R. Bateman, P. Pallai, K. M. Shokat, J. D. Baxter, R. K. Guy, et al. A surface on the androgen receptor that allosterically regulates coactivator binding
PNAS,
October 9, 2007;
104(41):
16074 - 16079.
[Abstract][Full Text][PDF]
H. R. Qin, D. Iliopoulos, T. Nakamura, S. Costinean, S. Volinia, T. Druck, J. Sun, H. Okumura, and K. Huebner Wwox Suppresses Prostate Cancer Cell Growth through Modulation of ErbB2-Mediated Androgen Receptor Signaling
Mol. Cancer Res.,
September 1, 2007;
5(9):
957 - 965.
[Abstract][Full Text][PDF]
S. Lindstrom, H.-O. Adami, K. A. Balter, J. Xu, S. L. Zheng, P. Stattin, H. Gronberg, and F. Wiklund Inherited Variation in Hormone-Regulating Genes and Prostate Cancer Survival
Clin. Cancer Res.,
September 1, 2007;
13(17):
5156 - 5161.
[Abstract][Full Text][PDF]
Y. Dai, D. Ngo, L. W. Forman, D. C. Qin, J. Jacob, and D. V. Faller Sirtuin 1 Is Required for Antagonist-Induced Transcriptional Repression of Androgen-Responsive Genes by the Androgen Receptor
Mol. Endocrinol.,
August 1, 2007;
21(8):
1807 - 1821.
[Abstract][Full Text][PDF]
N. Sharifi, E. Hamel, M. A. Lill, P. Risbood, C. T. Kane Jr., M. T. Hossain, A. Jones, J. T. Dalton, and W. L. Farrar A bifunctional colchicinoid that binds to the androgen receptor
Mol. Cancer Ther.,
August 1, 2007;
6(8):
2328 - 2336.
[Abstract][Full Text][PDF]
Y. Li, Z. Wang, D. Kong, S. Murthy, Q. P. Dou, S. Sheng, G. P. V. Reddy, and F. H. Sarkar Regulation of FOXO3a/beta-Catenin/GSK-3beta Signaling by 3,3'-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Prostate Cancer Cells
J. Biol. Chem.,
July 20, 2007;
282(29):
21542 - 21550.
[Abstract][Full Text][PDF]
M. M. Shen and C. Abate-Shen Pten Inactivation and the Emergence of Androgen-Independent Prostate Cancer
Cancer Res.,
July 15, 2007;
67(14):
6535 - 6538.
[Abstract][Full Text][PDF]
S. Lu, A. Wang, S. Lu, and Z. Dong A novel synthetic compound that interrupts androgen receptor signaling in human prostate cancer cells
Mol. Cancer Ther.,
July 1, 2007;
6(7):
2057 - 2064.
[Abstract][Full Text][PDF]
Y. Xie, D. W. Wolff, M.-F. Lin, and Y. Tu Vasoactive Intestinal Peptide Transactivates the Androgen Receptor through a Protein Kinase A-Dependent Extracellular Signal-Regulated Kinase Pathway in Prostate Cancer LNCaP Cells
Mol. Pharmacol.,
July 1, 2007;
72(1):
73 - 85.
[Abstract][Full Text][PDF]
H. Nakauchi, K.-i. Matsuda, I. Ochiai, A. Kawauchi, Y. Mizutani, T. Miki, and M. Kawata A Differential Ligand-mediated Response of Green Fluorescent Protein-tagged Androgen Receptor in Living Prostate Cancer and Non-prostate Cancer Cell Lines
J. Histochem. Cytochem.,
June 1, 2007;
55(6):
535 - 544.
[Abstract][Full Text][PDF]
T. I. Klokk, A. Kilander, Z. Xi, H. Waehre, B. Risberg, H. E. Danielsen, and F. Saatcioglu Kallikrein 4 Is a Proliferative Factor that Is Overexpressed in Prostate Cancer
Cancer Res.,
June 1, 2007;
67(11):
5221 - 5230.
[Abstract][Full Text][PDF]
J. E. Tillman, J. Yuan, G. Gu, L. Fazli, R. Ghosh, A. S. Flynt, M. Gleave, P. S. Rennie, and S. Kasper DJ-1 Binds Androgen Receptor Directly and Mediates Its Activity in Hormonally Treated Prostate Cancer Cells
Cancer Res.,
May 15, 2007;
67(10):
4630 - 4637.
[Abstract][Full Text][PDF]
G. Gu, J. Yuan, M. Wills, and S. Kasper Prostate Cancer Cells with Stem Cell Characteristics Reconstitute the Original Human Tumor In vivo
Cancer Res.,
May 15, 2007;
67(10):
4807 - 4815.
[Abstract][Full Text][PDF]
U. Simanainen, C. M. Allan, P. Lim, S. McPherson, M. Jimenez, J. D. Zajac, R. A. Davey, and D. J. Handelsman Disruption of Prostate Epithelial Androgen Receptor Impedes Prostate Lobe-Specific Growth and Function
Endocrinology,
May 1, 2007;
148(5):
2264 - 2272.
[Abstract][Full Text][PDF]
H. Miyamoto, Z. Yang, Y.-T. Chen, H. Ishiguro, H. Uemura, Y. Kubota, Y. Nagashima, Y.-J. Chang, Y.-C. Hu, M.-Y. Tsai, et al. Promotion of Bladder Cancer Development and Progression by Androgen Receptor Signals
J Natl Cancer Inst,
April 4, 2007;
99(7):
558 - 568.
[Abstract][Full Text][PDF]
J. Guo, C. Jiang, Z. Wang, H.-J. Lee, H. Hu, B. Malewicz, H.-J. Lee, J.-H. Lee, N.-I. Baek, J.-H. Jeong, et al. A novel class of pyranocoumarin anti-androgen receptor signaling compounds
Mol. Cancer Ther.,
March 1, 2007;
6(3):
907 - 917.
[Abstract][Full Text][PDF]
C.-M. Chiu, S.-H. Yeh, P.-J. Chen, T.-J. Kuo, C.-J. Chang, P.-J. Chen, W.-J. Yang, and D.-S. Chen Inaugural Article: Hepatitis B virus X protein enhances androgen receptor-responsive gene expression depending on androgen level
PNAS,
February 20, 2007;
104(8):
2571 - 2578.
[Abstract][Full Text][PDF]
L. Bonaccorsi, D. Nosi, M. Muratori, L. Formigli, G. Forti, and E. Baldi Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines
J. Mol. Endocrinol.,
January 1, 2007;
38(1):
51 - 66.
[Abstract][Full Text][PDF]
S. Srinivasan, R. S. Ranga, R. Burikhanov, S.-S. Han, and D. Chendil Par-4-Dependent Apoptosis by the Dietary Compound Withaferin A in Prostate Cancer Cells
Cancer Res.,
January 1, 2007;
67(1):
246 - 253.
[Abstract][Full Text][PDF]
R.-S. Wang, S. Yeh, L.-M. Chen, H.-Y. Lin, C. Zhang, J. Ni, C.-C. Wu, P. A. di Sant'Agnese, K. L. deMesy-Bentley, C.-R. Tzeng, et al. Androgen Receptor in Sertoli Cell Is Essential for Germ Cell Nursery and Junctional Complex Formation in Mouse Testes
Endocrinology,
December 1, 2006;
147(12):
5624 - 5633.
[Abstract][Full Text][PDF]
C. Zhang, S. Yeh, Y.-T. Chen, C.-C. Wu, K.-H. Chuang, H.-Y. Lin, R.-S. Wang, Y.-J. Chang, C. Mendis-Handagama, L. Hu, et al. Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells
PNAS,
November 21, 2006;
103(47):
17718 - 17723.
[Abstract][Full Text][PDF]
R. Ilagan, J. Pottratz, K. Le, L. Zhang, S. G. Wong, R. Ayala, M. Iyer, L. Wu, S. S. Gambhir, and M. Carey Imaging Mitogen-Activated Protein Kinase Function in Xenograft Models of Prostate Cancer.
Cancer Res.,
November 15, 2006;
66(22):
10778 - 10785.
[Abstract][Full Text][PDF]
I. U. Agoulnik, A. Vaid, M. Nakka, M. Alvarado, W. E. Bingman III, H. Erdem, A. Frolov, C. L. Smith, G. E. Ayala, M. M. Ittmann, et al. Androgens Modulate Expression of Transcription Intermediary Factor 2, an Androgen Receptor Coactivator whose Expression Level Correlates with Early Biochemical Recurrence in Prostate Cancer
Cancer Res.,
November 1, 2006;
66(21):
10594 - 10602.
[Abstract][Full Text][PDF]
S. Rajender, V. Rajani, N. J. Gupta, B. Chakravarty, L. Singh, and K. Thangaraj No Association of Androgen Receptor GGN Repeat Length Polymorphism With Infertility in Indian Men
J Androl,
November 1, 2006;
27(6):
785 - 789.
[Abstract][Full Text][PDF]
M. M.R. Bhuiyan, Y. Li, S. Banerjee, F. Ahmed, Z. Wang, S. Ali, and F. H. Sarkar Down-regulation of Androgen Receptor by 3,3'-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Both Hormone-Sensitive LNCaP and Insensitive C4-2B Prostate Cancer Cells.
Cancer Res.,
October 15, 2006;
66(20):
10064 - 10072.
[Abstract][Full Text][PDF]
H. V. Heemers, G. Verhoeven, and J. V. Swinnen Androgen Activation of the Sterol Regulatory Element-Binding Protein Pathway: Current Insights
Mol. Endocrinol.,
October 1, 2006;
20(10):
2265 - 2277.
[Abstract][Full Text][PDF]
R. Guo, E. A. Kasbohm, P. Arora, C. J. Sample, B. Baban, N. Sud, P. Sivashanmugam, N. H. Moniri, and Y. Daaka Expression and Function of Lysophosphatidic Acid LPA1 Receptor in Prostate Cancer Cells
Endocrinology,
October 1, 2006;
147(10):
4883 - 4892.
[Abstract][Full Text][PDF]
L.G. Wang, X.M. Liu, and J.W. Chiao Repression of androgen receptor in prostate cancer cells by phenethyl isothiocyanate
Carcinogenesis,
October 1, 2006;
27(10):
2124 - 2132.
[Abstract][Full Text][PDF]
H. Gao, X. Ouyang, W. A. Banach-Petrosky, W. L. Gerald, M. M. Shen, and C. Abate-Shen Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer
PNAS,
September 26, 2006;
103(39):
14477 - 14482.
[Abstract][Full Text][PDF]
S. M. Dehm and D. J. Tindall Ligand-independent Androgen Receptor Activity Is Activation Function-2-independent and Resistant to Antiandrogens in Androgen Refractory Prostate Cancer Cells
J. Biol. Chem.,
September 22, 2006;
281(38):
27882 - 27893.
[Abstract][Full Text][PDF]
H. Gao, X. Ouyang, W. A. Banach-Petrosky, M. M. Shen, and C. Abate-Shen Emergence of Androgen Independence at Early Stages of Prostate Cancer Progression in Nkx3.1; Pten Mice
Cancer Res.,
August 15, 2006;
66(16):
7929 - 7933.
[Abstract][Full Text][PDF]
X.-Y. Dong, C. Chen, X. Sun, P. Guo, R. L. Vessella, R.-X. Wang, L. W.K. Chung, W. Zhou, and J.-T. Dong FOXO1A Is a Candidate for the 13q14 Tumor Suppressor Gene Inhibiting Androgen Receptor Signaling in Prostate Cancer.
Cancer Res.,
July 15, 2006;
66(14):
6998 - 7006.
[Abstract][Full Text][PDF]
M. A. Albertelli, A. Scheller, M. Brogley, and D. M. Robins Replacing the Mouse Androgen Receptor with Human Alleles Demonstrates Glutamine Tract Length-Dependent Effects on Physiology and Tumorigenesis in Mice
Mol. Endocrinol.,
June 1, 2006;
20(6):
1248 - 1260.
[Abstract][Full Text][PDF]
P. J.M. Hendriksen, N. F.J. Dits, K. Kokame, A. Veldhoven, W. M. van Weerden, C. H. Bangma, J. Trapman, and G. Jenster Evolution of the Androgen Receptor Pathway during Progression of Prostate Cancer.
Cancer Res.,
May 15, 2006;
66(10):
5012 - 5020.
[Abstract][Full Text][PDF]
U. K. Misra, R. Deedwania, and S. V. Pizzo Activation and Cross-talk between Akt, NF-{kappa}B, and Unfolded Protein Response Signaling in 1-LN Prostate Cancer Cells Consequent to Ligation of Cell Surface-associated GRP78
J. Biol. Chem.,
May 12, 2006;
281(19):
13694 - 13707.
[Abstract][Full Text][PDF]
L. S. Lyons and K. L. Burnstein Vav3, a Rho GTPase Guanine Nucleotide Exchange Factor, Increases during Progression to Androgen Independence in Prostate Cancer Cells and Potentiates Androgen Receptor Transcriptional Activity
Mol. Endocrinol.,
May 1, 2006;
20(5):
1061 - 1072.
[Abstract][Full Text][PDF]
S. M. Hillier, J. C. Marquis, B. Zayas, J. S. Wishnok, R. G. Liberman, P. L. Skipper, S. R. Tannenbaum, J. M. Essigmann, and R. G. Croy DNA adducts formed by a novel antitumor agent 11{beta}-dichloro in vitro and in vivo.
Mol. Cancer Ther.,
April 1, 2006;
5(4):
977 - 984.
[Abstract][Full Text][PDF]
R. K. Allan, D. Mok, B. K. Ward, and T. Ratajczak Modulation of Chaperone Function and Cochaperone Interaction by Novobiocin in the C-terminal Domain of Hsp90: EVIDENCE THAT COUMARIN ANTIBIOTICS DISRUPT Hsp90 DIMERIZATION
J. Biol. Chem.,
March 17, 2006;
281(11):
7161 - 7171.
[Abstract][Full Text][PDF]
B. He, R. T. Gampe Jr., A. T. Hnat, J. L. Faggart, J. T. Minges, F. S. French, and E. M. Wilson Probing the Functional Link between Androgen Receptor Coactivator and Ligand-binding Sites in Prostate Cancer and Androgen Insensitivity
J. Biol. Chem.,
March 10, 2006;
281(10):
6648 - 6663.
[Abstract][Full Text][PDF]
O. Y. Khan, G. Fu, A. Ismail, S. Srinivasan, X. Cao, Y. Tu, S. Lu, and Z. Nawaz Multifunction Steroid Receptor Coactivator, E6-Associated Protein, Is Involved in Development of the Prostate Gland
Mol. Endocrinol.,
March 1, 2006;
20(3):
544 - 559.
[Abstract][Full Text][PDF]
C. Jiang, H.-J. Lee, G.-x. Li, J. Guo, B. Malewicz, Y. Zhao, E.-O. Lee, H.-J. Lee, J.-H. Lee, M.-S. Kim, et al. Potent Antiandrogen and Androgen Receptor Activities of an Angelica gigas-Containing Herbal Formulation: Identification of Decursin as a Novel and Active Compound with Implications for Prevention and Treatment of Prostate Cancer
Cancer Res.,
January 1, 2006;
66(1):
453 - 463.
[Abstract][Full Text][PDF]
L. Callewaert, N. Van Tilborgh, and F. Claessens Interplay between Two Hormone-Independent Activation Domains in the Androgen Receptor
Cancer Res.,
January 1, 2006;
66(1):
543 - 553.
[Abstract][Full Text][PDF]
A. J. Asirvatham, M. Schmidt, B. Gao, and J. Chaudhary Androgens Regulate the Immune/Inflammatory Response and Cell Survival Pathways in Rat Ventral Prostate Epithelial Cells
Endocrinology,
January 1, 2006;
147(1):
257 - 271.
[Abstract][Full Text][PDF]
D. J. Mulholland, S. Dedhar, G. A. Coetzee, and C. C. Nelson Interaction of Nuclear Receptors with the Wnt/{beta}-Catenin/Tcf Signaling Axis: Wnt You Like to Know?
Endocr. Rev.,
December 1, 2005;
26(7):
898 - 915.
[Abstract][Full Text][PDF]
