| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794
Correspondence: Address all correspondence and requests for reprints to: Jeffrey E. Pessin, Ph.D., Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794. E-mail: pessin{at}pharm.sunysb.edu
Since the discovery of insulin roughly 80 yr ago, much has been learned about how target cells receive, interpret, and respond to this peptide hormone. For example, we now know that insulin activates the tyrosine kinase activity of its cell surface receptor, thereby triggering intracellular signaling cascades that regulate many cellular processes. With respect to glucose homeostasis, these include the function of insulin to suppress hepatic glucose production and to increase glucose uptake in muscle and adipose tissues, the latter resulting from the translocation of the glucose transporter 4 (GLUT4) to the cell surface membrane. Although simple in broad outline, elucidating the molecular intricacies of these receptor-signaling pathways and membrane-trafficking processes continues to challenge the creative ingenuity of scientists, and many questions remain unresolved, or even perhaps unasked. The identification and functional characterization of specific molecules required for both insulin signaling and GLUT4 vesicle trafficking remain key issues in our pursuit of developing specific therapeutic agents to treat and/or prevent this debilitating disease process. To this end, the combined efforts of numerous research groups employing a range of experimental approaches has led to a clearer molecular picture of how insulin regulates the membrane trafficking of GLUT4.
This article has been cited by other articles:
![]() |
V. Blot and T. E. McGraw Molecular Mechanisms Controlling GLUT4 Intracellular Retention Mol. Biol. Cell, August 1, 2008; 19(8): 3477 - 3487. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Karnieli and M. Armoni Transcriptional regulation of the insulin-responsive glucose transporter GLUT4 gene: from physiology to pathology Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E38 - E45. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. K. Tee, Q. Dong, and W. L. Miller Pathways Leading to Phosphorylation of P450c17 and to the Posttranslational Regulation of Androgen Biosynthesis Endocrinology, May 1, 2008; 149(5): 2667 - 2677. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. T. Watson and J. E. Pessin Recycling of IRAP from the plasma membrane back to the insulin-responsive compartment requires the Q-SNARE syntaxin 6 but not the GGA clathrin adaptors J. Cell Sci., April 15, 2008; 121(8): 1243 - 1251. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Lei, C. N. Mariash, M. Bhargava, E. V. Wattenberg, and D. H. Ingbar T3 increases Na-K-ATPase activity via a MAPK/ERK1/2-dependent pathway in rat adult alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L749 - L754. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Zhang, J. S. Helm, A. Senatore, J. D. Spafford, L. K. Kaczmarek, and E. A. Jonas PKC-Induced Intracellular Trafficking of CaV2 Precedes Its Rapid Recruitment to the Plasma Membrane J. Neurosci., March 5, 2008; 28(10): 2601 - 2612. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Paterson, I. R Kelsall, and P. T W Cohen Disruption of the striated muscle glycogen-targeting subunit of protein phosphatase 1: influence of the genetic background J. Mol. Endocrinol., February 1, 2008; 40(2): 47 - 59. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Zhang, X. Li, W. Lv, Y. Yang, H. Gao, J. Yang, Y. Shen, and G. Ning Ginsenoside Re Reduces Insulin Resistance through Inhibition of c-Jun NH2-Terminal Kinase and Nuclear Factor-{kappa}B Mol. Endocrinol., January 1, 2008; 22(1): 186 - 195. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Huang, R. A. Charbeneau, Y. Fu, K. Kaur, I. Gerin, O. A. MacDougald, and R. R. Neubig Resistance to Diet-Induced Obesity and Improved Insulin Sensitivity in Mice With a Regulator of G Protein Signaling Insensitive G184S Gnai2 Allele Diabetes, January 1, 2008; 57(1): 77 - 85. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Capilla, N. Suzuki, J. E. Pessin, and J. C. Hou The Glucose Transporter 4 FQQI Motif Is Necessary for Akt Substrate of 160-Kilodalton-Dependent Plasma Membrane Translocation But Not Golgi-Localized {gamma}-Ear-Containing Arf-Binding Protein-Dependent Entry into the Insulin-Responsive Storage Compartment Mol. Endocrinol., December 1, 2007; 21(12): 3087 - 3099. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. L. Gathercole, I. J. Bujalska, P. M. Stewart, and J. W. Tomlinson Glucocorticoid Modulation of Insulin Signaling in Human Subcutaneous Adipose Tissue J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4332 - 4339. [Abstract] [Full Text] [PDF] |
||||
![]() |
A.-V. Cantero, M. Portero-Otin, V. Ayala, N. Auge, M. Sanson, M. Elbaz, J.-C. Thiers, R. Pamplona, R. Salvayre, and A. Negre-Salvayre Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-{beta}: implications for diabetic atherosclerosis FASEB J, October 1, 2007; 21(12): 3096 - 3106. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Fujiwara, M. Hiroyama, A. Sanbe, T. Aoyagi, J.-i. Birumachi, J. Yamauchi, G. Tsujimoto, and A. Tanoue Insulin hypersensitivity in mice lacking the V1b vasopressin receptor J. Physiol., October 1, 2007; 584(1): 235 - 244. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Zheng, R. Vassena, and K. E. Latham Effects of in vitro oocyte maturation and embryo culture on the expression of glucose transporters, glucose metabolism and insulin signaling genes in rhesus monkey oocytes and preimplantation embryos Mol. Hum. Reprod., June 1, 2007; 13(6): 361 - 371. [Abstract] [Full Text] [PDF] |
||||
![]() |
F.-Q. Zhao and A. F. Keating Expression and Regulation of Glucose Transporters in the Bovine Mammary Gland J Dairy Sci, June 1, 2007; 90(13_suppl): E76 - E86. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Huang, L. M. Lifshitz, C. Jones, K. D. Bellve, C. Standley, S. Fonseca, S. Corvera, K. E. Fogarty, and M. P. Czech Insulin Stimulates Membrane Fusion and GLUT4 Accumulation in Clathrin Coats on Adipocyte Plasma Membranes Mol. Cell. Biol., May 1, 2007; 27(9): 3456 - 3469. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. L. Wieman, J. A. Wofford, and J. C. Rathmell Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking Mol. Biol. Cell, April 1, 2007; 18(4): 1437 - 1446. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Yu, J. Cresswell, M. G. Loffler, and J. S. Bogan The Glucose Transporter 4-regulating Protein TUG Is Essential for Highly Insulin-responsive Glucose Uptake in 3T3-L1 Adipocytes J. Biol. Chem., March 9, 2007; 282(10): 7710 - 7722. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Chang, S.-H. Chiang, and A. R. Saltiel TC10{alpha} Is Required for Insulin-Stimulated Glucose Uptake in Adipocytes Endocrinology, January 1, 2007; 148(1): 27 - 33. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Hatanaka, Y. Hatanaka, J.-i. Tsuchida, V. Ganapathy, and M. Setou Amino Acid Transporter ATA2 Is Stored at the trans-Golgi Network and Released by Insulin Stimulus in Adipocytes J. Biol. Chem., December 22, 2006; 281(51): 39273 - 39284. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. D. Johnson, E. Bernal-Mizrachi, E. U. Alejandro, Z. Han, T. B. Kalynyak, H. Li, J. L. Beith, J. Gross, G. L. Warnock, R. R. Townsend, et al. Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome PNAS, December 19, 2006; 103(51): 19575 - 19580. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Zegzouti, W. Li, T. C. Lorenz, M. Xie, C. T. Payne, K. Smith, S. Glenny, G. S. Payne, and S. K. Christensen Structural and Functional Insights into the Regulation of Arabidopsis AGC VIIIa Kinases J. Biol. Chem., November 17, 2006; 281(46): 35520 - 35530. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Barres, T. Gremeaux, P. Gual, T. Gonzalez, J. Gugenheim, A. Tran, Y. Le Marchand-Brustel, and J.-F. Tanti Enigma Interacts with Adaptor Protein with PH and SH2 Domains to Control Insulin-Induced Actin Cytoskeleton Remodeling and Glucose Transporter 4 Translocation Mol. Endocrinol., November 1, 2006; 20(11): 2864 - 2875. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Nedachi and M. Kanzaki Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E817 - E828. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Liu, M. P. Jedrychowski, S. P. Gygi, and P. F. Pilch Role of Insulin-dependent Cortical Fodrin/Spectrin Remodeling in Glucose Transporter 4 Translocation in Rat Adipocytes Mol. Biol. Cell, October 1, 2006; 17(10): 4249 - 4256. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Ramm, M. Larance, M. Guilhaus, and D. E. James A Role for 14-3-3 in Insulin-stimulated GLUT4 Translocation through Its Interaction with the RabGAP AS160 J. Biol. Chem., September 29, 2006; 281(39): 29174 - 29180. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. M. Kong, K. A. Horan, A. Sriratana, C. G. Bailey, L. J. Collyer, H. H. Nandurkar, A. Shisheva, M. J. Layton, J. E. J. Rasko, T. Rowe, et al. Phosphatidylinositol 3-Phosphate [PtdIns(3)P] Is Generated at the Plasma Membrane by an Inositol Polyphosphate 5-Phosphatase: Endogenous PtdIns(3)P Can Promote GLUT4 Translocation to the Plasma Membrane. Mol. Cell. Biol., August 1, 2006; 26(16): 6065 - 6081. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Schmelzle, S. Kane, S. Gridley, G. E. Lienhard, and F. M. White Temporal dynamics of tyrosine phosphorylation in insulin signaling. Diabetes, August 1, 2006; 55(8): 2171 - 2179. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Boixel, B. Gavillet, J.-S. Rougier, and H. Abriel Aldosterone increases voltage-gated sodium current in ventricular myocytes Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2257 - H2266. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A. Doughty, B. F. Bleiman, D. J. Wagner, F. J. Dufort, J. M. Mataraza, M. F. Roberts, and T. C. Chiles Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth Blood, June 1, 2006; 107(11): 4458 - 4465. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Liao, M. T. A. Nguyen, T. Imamura, O. Singer, I. M. Verma, and J. M. Olefsky Lentiviral Short Hairpin Ribonucleic Acid-Mediated Knockdown of GLUT4 in 3T3-L1 Adipocytes Endocrinology, May 1, 2006; 147(5): 2245 - 2252. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Procino, D. B. Caces, G. Valenti, and J. E. Pessin Adipocytes support cAMP-dependent translocation of aquaporin-2 from intracellular sites distinct from the insulin-responsive GLUT4 storage compartment Am J Physiol Renal Physiol, May 1, 2006; 290(5): F985 - F994. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Zegzouti, R. G. Anthony, N. Jahchan, L. Bogre, and S. K. Christensen Phosphorylation and activation of PINOID by the phospholipid signaling kinase 3-phosphoinositide-dependent protein kinase 1 (PDK1) in Arabidopsis PNAS, April 18, 2006; 103(16): 6404 - 6409. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Hers, M. Wherlock, Y. Homma, H. Yagisawa, and J. M. Tavare Identification of p122RhoGAP (Deleted in Liver Cancer-1) Serine 322 as a Substrate for Protein Kinase B and Ribosomal S6 Kinase in Insulin-stimulated Cells J. Biol. Chem., February 24, 2006; 281(8): 4762 - 4770. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. L. Sheldon, M. I. Gonzalez, and M. B. Robinson A Carboxyl-terminal Determinant of the Neuronal Glutamate Transporter, EAAC1, Is Required for Platelet-derived Growth Factor-dependent Trafficking J. Biol. Chem., February 24, 2006; 281(8): 4876 - 4886. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. E. FRIDLYAND and L. H. PHILIPSON Oxidative Reactive Species in Cell Injury: Mechanisms in Diabetes Mellitus and Therapeutic Approaches Ann. N.Y. Acad. Sci., December 1, 2005; 1066(1): 136 - 151. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Ishiki and A. Klip Minireview: Recent Developments in the Regulation of Glucose Transporter-4 Traffic: New Signals, Locations, and Partners Endocrinology, December 1, 2005; 146(12): 5071 - 5078. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Turban, V. A. Beardmore, J. M. Carr, K. Sakamoto, E. Hajduch, J. S. C. Arthur, and H. S. Hundal Insulin-Stimulated Glucose Uptake Does Not Require p38 Mitogen-Activated Protein Kinase in Adipose Tissue or Skeletal Muscle Diabetes, November 1, 2005; 54(11): 3161 - 3168. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Liu, J. C. Hou, R. T. Watson, and J. E. Pessin Initial entry of IRAP into the insulin-responsive storage compartment occurs prior to basal or insulin-stimulated plasma membrane recycling Am J Physiol Endocrinol Metab, November 1, 2005; 289(5): E746 - E752. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Gonzalez-Yanes, A. Serrano, F. J. Bermudez-Silva, M. Hernandez-Dominguez, M. A. Paez-Ochoa, F. R. de Fonseca, and V. Sanchez-Margalet Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways Am J Physiol Endocrinol Metab, November 1, 2005; 289(5): E923 - E929. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Wettschureck and S. Offermanns Mammalian G Proteins and Their Cell Type Specific Functions Physiol Rev, October 1, 2005; 85(4): 1159 - 1204. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. S. L. Thong, C. B. Dugani, and A. Klip Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway Physiology, August 1, 2005; 20(4): 271 - 284. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Yamada, S. Okada, T. Saito, K. Ohshima, M. Sato, T. Tsuchiya, Y. Uehara, H. Shimizu, and M. Mori Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles J. Cell Biol., March 14, 2005; 168(6): 921 - 928. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Sekine-Aizawa and R. L. Huganir From the Cover: Imaging of receptor trafficking by using {alpha}-bungarotoxin-binding-site-tagged receptors PNAS, December 7, 2004; 101(49): 17114 - 17119. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |