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Endocrine Reviews 25 (1): 1-44
Copyright © 2004 by The Endocrine Society

Endocrine Aspects of Cancer Gene Therapy

Luisa Barzon, Marco Boscaro and Giorgio Palù

Department of Histology, Microbiology, and Medical Biotechnologies (L.B., G.P.), University of Padova, I-35121 Padova, Italy; and Department of Internal Medicine, Division of Endocrinology (M.B.), University of Ancona, 60100 Ancona, Italy

Correspondence: Address all correspondence and requests for reprints to: Giorgio Palù, M.D., Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, via Gabelli 63, I-35121 Padova, Italy. E-mail: giorgio.palu{at}unipd.it

The field of cancer gene therapy is in continuous expansion, and technology is quickly moving ahead as far as gene targeting and regulation of gene expression are concerned. This review focuses on the endocrine aspects of gene therapy, including the possibility to exploit hormone and hormone receptor functions for regulating therapeutic gene expression, the use of endocrine-specific genes as new therapeutic tools, the effects of viral vector delivery and transgene expression on the endocrine system, and the endocrine response to viral vector delivery. Present ethical concerns of gene therapy and the risk of germ cell transduction are also discussed, along with potential lines of innovation to improve cell and gene targeting.




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Copyright © 2004 by The Endocrine Society