Role of Gastrointestinal Hormones in the Proliferation of Normal and Neoplastic Tissues
Robert P. Thomas,
Mark R. Hellmich,
Courtney M. Townsend, Jr. and
B. Mark Evers
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555
Correspondence: Address all correspondence and requests for reprints to: B. Mark Evers, M.D., Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0536. E-mail: mevers{at}utmb.edu
Gastrointestinal (GI) hormones are chemical messengers thatregulate the physiological functions of the intestine and pancreas,including secretion, motility, absorption, and digestion. Inaddition to these well-defined physiological effects, GI hormonescan stimulate proliferation of the nonneoplastic intestinalmucosa and pancreas. Furthermore, in an analogous fashion tobreast and prostate cancer, certain GI cancers possess receptorsfor GI hormones; growth can be altered by administration ofthese hormones or by blocking their respective receptors. TheGI hormones that affect proliferation, either stimulatory orinhibitory, include gastrin, cholecystokinin, gastrin-releasingpeptide, neurotensin, peptide YY, glucagon-like peptide-2, andsomatostatin. The effects of these peptides on normal and neoplasticGI tissues will be described. Also, future perspectives andpotential therapeutic implications will be discussed.
This article has been cited by other articles:
C. S. Aung, W. Ye, G. Plowman, A. A. Peters, G. R. Monteith, and S. J. Roberts-Thomson Plasma membrane calcium ATPase 4 and the remodeling of calcium homeostasis in human colon cancer cells
Carcinogenesis,
November 1, 2009;
30(11):
1962 - 1969.
[Abstract][Full Text][PDF]
L. A. Chen, J. Li, S. R. Silva, L. N. Jackson, Y. Zhou, H. Watanabe, K. L. Ives, M. R. Hellmich, and B. M. Evers PKD3 Is the Predominant Protein Kinase D Isoform in Mouse Exocrine Pancreas and Promotes Hormone-induced Amylase Secretion
J. Biol. Chem.,
January 23, 2009;
284(4):
2459 - 2471.
[Abstract][Full Text][PDF]
B. J. Wang and Z. J. Cui How does cholecystokinin stimulate exocrine pancreatic secretion? From birds, rodents, to humans
Am J Physiol Regulatory Integrative Comp Physiol,
February 1, 2007;
292(2):
R666 - R678.
[Abstract][Full Text][PDF]
J. Li, K. L. O'Connor, X. Cheng, F. C. Mei, T. Uchida, C. M. Townsend Jr, and B. M. Evers Cyclic Adenosine 5'-Monophosphate-Stimulated Neurotensin Secretion Is Mediated through Rap1 Downstream of both Epac and Protein Kinase A Signaling Pathways
Mol. Endocrinol.,
January 1, 2007;
21(1):
159 - 171.
[Abstract][Full Text][PDF]
S. Schulz, C. Rocken, M. P A Ebert, and S. Schulz Immunocytochemical identification of low-affinity NTS2 neurotensin receptors in parietal cells of human gastric mucosa.
J. Endocrinol.,
October 1, 2006;
191(1):
121 - 128.
[Abstract][Full Text][PDF]
X. Wang, Q. Wang, K. L. Ives, and B. M. Evers Curcumin Inhibits Neurotensin-Mediated Interleukin-8 Production and Migration of HCT116 Human Colon Cancer Cells.
Clin. Cancer Res.,
September 15, 2006;
12(18):
5346 - 5355.
[Abstract][Full Text][PDF]
F. Souaze, S. Dupouy, V. Viardot-Foucault, E. Bruyneel, S. Attoub, C. Gespach, A. Gompel, and P. Forgez Expression of Neurotensin and NT1 Receptor in Human Breast Cancer: A Potential Role in Tumor Progression.
Cancer Res.,
June 15, 2006;
66(12):
6243 - 6249.
[Abstract][Full Text][PDF]
F. Souaze, V. Viardot-Foucault, N. Roullet, M. Toy-Miou-Leong, A. Gompel, E. Bruyneel, E. Comperat, M. C Faux, M. Mareel, W. Rostene, et al. Neurotensin receptor 1 gene activation by the Tcf/{beta}-catenin pathway is an early event in human colonic adenomas
Carcinogenesis,
April 1, 2006;
27(4):
708 - 716.
[Abstract][Full Text][PDF]
F. Dal-Pizzol, L. P. Di Leone, C. Ritter, M. R. Martins, A. Reinke, D. Pens Gelain, A. Zanotto-Filho, L. F. de Souza, M. Andrades, D. F. Barbeiro, et al. Gastrin-releasing Peptide Receptor Antagonist Effects on an Animal Model of Sepsis
Am. J. Respir. Crit. Care Med.,
January 1, 2006;
173(1):
84 - 90.
[Abstract][Full Text][PDF]
J. Li, K. L. O'Connor, G. H. Greeley Jr., P. J. Blackshear, C. M. Townsend Jr., and B. M. Evers Myristoylated Alanine-rich C Kinase Substrate-mediated Neurotensin Release via Protein Kinase C-{delta} Downstream of the Rho/ROK Pathway
J. Biol. Chem.,
March 4, 2005;
280(9):
8351 - 8357.
[Abstract][Full Text][PDF]
N. Li, Q. Wang, J. Li, X. Wang, M. R. Hellmich, S. Rajaraman, G. H. Greeley Jr., C. M. Townsend Jr., and B. M. Evers Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON
Am J Physiol Gastrointest Liver Physiol,
February 1, 2005;
288(2):
G213 - G220.
[Abstract][Full Text][PDF]
J. Li, K. L. O'Connor, M. R. Hellmich, G. H. Greeley Jr., C. M. Townsend Jr., and B. M. Evers The Role of Protein Kinase D in Neurotensin Secretion Mediated by Protein Kinase C-{alpha}/-{delta} and Rho/Rho Kinase
J. Biol. Chem.,
July 2, 2004;
279(27):
28466 - 28474.
[Abstract][Full Text][PDF]
P. L. Brubaker and D. J. Drucker Minireview: Glucagon-Like Peptides Regulate Cell Proliferation and Apoptosis in the Pancreas, Gut, and Central Nervous System
Endocrinology,
June 1, 2004;
145(6):
2653 - 2659.
[Abstract][Full Text][PDF]
