This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Firth, S. M. Articles by Baxter, R. C. Search for Related Content PubMed PubMed Citation Articles by Firth, S. M. Articles by Baxter, R. C.

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia

Correspondence: Address all correspondence and requests for reprints to: Robert C. Baxter, Ph.D., D.Sc., Kolling Institute of Medical Research, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. E-mail: robaxter{at}med.usyd.edu.au

In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may inhibit mitogenesis, differentiation, survival, and other IGF-stimulated events. IGFBP proteolysis can reverse this inhibition or generate IGFBP fragments with novel bioactivity. Alternatively, IGFBP interaction with cell or matrix components may concentrate IGFs near their receptor, enhancing IGF activity. IGF receptor-independent IGFBP actions are also increasingly recognized. IGFBP-1 interacts with ₅ß₁ integrin, influencing cell adhesion and migration. IGFBP-2, -3, -5, and -6 have heparin-binding domains and can bind glycosaminoglycans. IGFBP-3 and -5 have carboxyl-terminal basic motifs incorporating heparin-binding and additional basic residues that interact with the cell surface and matrix, the nuclear transporter importin-ß, and other proteins. Serine/threonine kinase receptors are proposed for IGFBP-3 and -5, but their signaling functions are poorly understood. Other cell surface IGFBP-interacting proteins are uncharacterized as functional receptors. However, IGFBP-3 binds and modulates the retinoid X receptor-, interacts with TGFß signaling through Smad proteins, and influences other signaling pathways. These interactions can modulate cell cycle and apoptosis. Because IGFBPs regulate cell functions by diverse mechanisms, manipulation of IGFBP-regulated pathways is speculated to offer therapeutic opportunities in cancer and other diseases.

This article has been cited by other articles:

				L. A. Mucci, J. R. Stark, M. N. Pollak, H. Li, T. Kurth, M. J. Stampfer, and J. Ma Plasma Levels of Acid-Labile Subunit, Free Insulin-Like Growth Factor-I, and Prostate Cancer Risk: A Prospective Study Cancer Epidemiol. Biomarkers Prev., February 1, 2010; 19(2): 484 - 491. [Abstract] [Full Text] [PDF]

				B. B Yeap, S A P. Chubb, K. K Y Ho, J. W S Setoh, K. A McCaul, P. E Norman, K. Jamrozik, and L. Flicker IGF1 and its binding proteins 3 and 1 are differentially associated with metabolic syndrome in older men Eur. J. Endocrinol., February 1, 2010; 162(2): 249 - 257. [Abstract] [Full Text] [PDF]

				N. M. Probst-Hensch, J. H.B. Steiner, P. Schraml, Z. Varga, U. Zurrer-Hardi, M. Storz, D. Korol, M. K. Fehr, D. Fink, B. C. Pestalozzi, et al. IGFBP2 and IGFBP3 Protein Expressions in Human Breast Cancer: Association with Hormonal Factors and Obesity Clin. Cancer Res., February 1, 2010; 16(3): 1025 - 1032. [Abstract] [Full Text] [PDF]

				C. E. Gleason, Y. Ning, T. P. Cominski, R. Gupta, K. H. Kaestner, J. E. Pintar, and M. J. Birnbaum Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic {beta}-Cell Growth Mol. Endocrinol., January 1, 2010; 24(1): 178 - 192. [Abstract] [Full Text] [PDF]

				S. A. Cain, A. McGovern, E. Small, L. J. Ward, C. Baldock, A. Shuttleworth, and C. M. Kielty Defining Elastic Fiber Interactions by Molecular Fishing: AN AFFINITY PURIFICATION AND MASS SPECTROMETRY APPROACH Mol. Cell. Proteomics, December 1, 2009; 8(12): 2715 - 2732. [Abstract] [Full Text] [PDF]

				S. Mukherjee, J. L. King, and C. Guidry Phenotype-Associated Changes in Retinal Pigment Epithelial Cell Expression of Insulin-Like Growth Factor Binding Proteins Invest. Ophthalmol. Vis. Sci., November 1, 2009; 50(11): 5449 - 5455. [Abstract] [Full Text] [PDF]

				Q. Jiao, A. M. Pruznak, D. Huber, T. C. Vary, and C. H. Lang Castration differentially alters basal and leucine-stimulated tissue protein synthesis in skeletal muscle and adipose tissue Am J Physiol Endocrinol Metab, November 1, 2009; 297(5): E1222 - E1232. [Abstract] [Full Text] [PDF]

				J. L. Kielczewski, Y. P.R. Jarajapu, E. L. McFarland, J. Cai, A. Afzal, S. Li Calzi, K. H. Chang, T. Lydic, L. C. Shaw, J. Busik, et al. Insulin-Like Growth Factor Binding Protein-3 Mediates Vascular Repair by Enhancing Nitric Oxide Generation Circ. Res., October 23, 2009; 105(9): 897 - 905. [Abstract] [Full Text] [PDF]

				L. J. Cobb, H. Mehta, and P. Cohen Enhancing the Apoptotic Potential of Insulin-Like Growth Factor-Binding Protein-3 in Prostate Cancer by Modulation of CK2 Phosphorylation Mol. Endocrinol., October 1, 2009; 23(10): 1624 - 1633. [Abstract] [Full Text] [PDF]

				J. L. Martin, M. Z. Lin, E. M. McGowan, and R. C. Baxter Potentiation of Growth Factor Signaling by Insulin-like Growth Factor-binding Protein-3 in Breast Epithelial Cells Requires Sphingosine Kinase Activity J. Biol. Chem., September 18, 2009; 284(38): 25542 - 25552. [Abstract] [Full Text] [PDF]

				R. M. Simmons, D. W. Erikson, J. Kim, R. C. Burghardt, F. W. Bazer, G. A. Johnson, and T. E. Spencer Insulin-Like Growth Factor Binding Protein-1 in the Ruminant Uterus: Potential Endometrial Marker and Regulator of Conceptus Elongation Endocrinology, September 1, 2009; 150(9): 4295 - 4305. [Abstract] [Full Text] [PDF]

				C. KRIEBITZSCH, L. VERLINDEN, G. EELEN, B. K. TAN, M. VAN CAMP, R. BOUILLON, and A. VERSTUYF The Impact of 1,25(OH)2D3 and its Structural Analogs on Gene Expression in Cancer Cells - A Microarray Approach Anticancer Res, September 1, 2009; 29(9): 3471 - 3483. [Abstract] [Full Text] [PDF]

				T. Yazawa, H. Sato, H. Shimoyamada, K. Okudela, T. Woo, M. Tajiri, T. Ogura, N. Ogawa, T. Suzuki, H. Mitsui, et al. Neuroendocrine Cancer-Specific Up-Regulating Mechanism of Insulin-Like Growth Factor Binding Protein-2 in Small Cell Lung Cancer Am. J. Pathol., September 1, 2009; 175(3): 976 - 987. [Abstract] [Full Text] [PDF]

				D. Zhong, L. Xiong, T. Liu, X. Liu, X. Liu, J. Chen, S.-Y. Sun, F. R. Khuri, Y. Zong, Q. Zhou, et al. The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R J. Biol. Chem., August 28, 2009; 284(35): 23225 - 23233. [Abstract] [Full Text] [PDF]

				S. Jogie-Brahim, D. Feldman, and Y. Oh Unraveling Insulin-Like Growth Factor Binding Protein-3 Actions in Human Disease Endocr. Rev., August 1, 2009; 30(5): 417 - 437. [Abstract] [Full Text] [PDF]

				S. RESSLER, J. RADHI, T. AIGNER, C. LOO, W. ZWERSCHKE, and C. SERGI Insulin-like Growth Factor-binding Protein-3 in Osteosarcomas and Normal Bone Tissues Anticancer Res, July 1, 2009; 29(7): 2579 - 2587. [Abstract] [Full Text] [PDF]

				P. M. Yamada and K.-W. Lee Perspectives in mammalian IGFBP-3 biology: local vs. systemic action Am J Physiol Cell Physiol, May 1, 2009; 296(5): C954 - C976. [Abstract] [Full Text] [PDF]

				X. Wang, L. Lu, Y. Li, M. Li, C. Chen, Q. Feng, C. Zhang, and C. Duan Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1348 - R1357. [Abstract] [Full Text] [PDF]

				A. Pokrajac, J. Frystyk, A. Flyvbjerg, and P. J Trainer Pituitary-independent effect of octreotide on IGF1 generation Eur. J. Endocrinol., April 1, 2009; 160(4): 543 - 548. [Abstract] [Full Text] [PDF]

				J. T. Ou, S. Q. Tang, D. X. Sun, and Y. Zhang Polymorphisms of three neuroendocrine-correlated genes associated with growth and reproductive traits in the chicken Poult. Sci., April 1, 2009; 88(4): 722 - 727. [Abstract] [Full Text] [PDF]

				M. Hansen, B. F. Miller, L. Holm, S. Doessing, S. G. Petersen, D. Skovgaard, J. Frystyk, A. Flyvbjerg, S. Koskinen, J. Pingel, et al. Effect of administration of oral contraceptives in vivo on collagen synthesis in tendon and muscle connective tissue in young women J Appl Physiol, April 1, 2009; 106(4): 1435 - 1443. [Abstract] [Full Text] [PDF]

				C. Lofqvist, K. L. Willett, O. Aspegren, A. C. H. Smith, C. M. Aderman, K. M. Connor, J. Chen, A. Hellstrom, and L. E. H. Smith Quantification and Localization of the IGF/Insulin System Expression in Retinal Blood Vessels and Neurons during Oxygen-Induced Retinopathy in Mice Invest. Ophthalmol. Vis. Sci., April 1, 2009; 50(4): 1831 - 1837. [Abstract] [Full Text] [PDF]

				S. S. Y. Chan, L. J. Schedlich, S. M. Twigg, and R. C. Baxter Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3 Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E654 - E663. [Abstract] [Full Text] [PDF]

				R. Kooijman, S. Sarre, Y. Michotte, and J. De Keyser Insulin-Like Growth Factor I: A Potential Neuroprotective Compound for the Treatment of Acute Ischemic Stroke? Stroke, April 1, 2009; 40(4): e83 - e88. [Abstract] [Full Text] [PDF]

				F. Tremblay, T. Revett, C. Huard, Y. Zhang, J. F. Tobin, R. V. Martinez, and R. E. Gimeno Bidirectional Modulation of Adipogenesis by the Secreted Protein Ccdc80/DRO1/URB J. Biol. Chem., March 20, 2009; 284(12): 8136 - 8147. [Abstract] [Full Text] [PDF]

				E. Muhlbradt, E. Asatiani, E. Ortner, A. Wang, and E. P. Gelmann NKX3.1 Activates Expression of Insulin-like Growth Factor Binding Protein-3 to Mediate Insulin-like Growth Factor-I Signaling and Cell Proliferation Cancer Res., March 15, 2009; 69(6): 2615 - 2622. [Abstract] [Full Text] [PDF]

				S. Yakar, C. J. Rosen, M. L. Bouxsein, H. Sun, W. Mejia, Y. Kawashima, Y. Wu, K. Emerton, V. Williams, K. Jepsen, et al. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism FASEB J, March 1, 2009; 23(3): 709 - 719. [Abstract] [Full Text] [PDF]

				S. Ismail, A. Sturrock, P. Wu, B. Cahill, K. Norman, T. Huecksteadt, K. Sanders, T. Kennedy, and J. Hoidal NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3 Am J Physiol Lung Cell Mol Physiol, March 1, 2009; 296(3): L489 - L499. [Abstract] [Full Text] [PDF]

				M. Li, Y. Li, L. Lu, X. Wang, Q. Gong, and C. Duan Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R558 - R566. [Abstract] [Full Text] [PDF]

				E. F. Costalonga, S. R. Antonini, G. Guerra-Junior, B. B. Mendonca, I. J. P. Arnhold, and A. A. L. Jorge The -202 A Allele of Insulin-Like Growth Factor Binding Protein-3 (IGFBP3) Promoter Polymorphism Is Associated with Higher IGFBP-3 Serum Levels and Better Growth Response to Growth Hormone Treatment in Patients with Severe Growth Hormone Deficiency J. Clin. Endocrinol. Metab., February 1, 2009; 94(2): 588 - 595. [Abstract] [Full Text] [PDF]

				K. Miyako, L. J. Cobb, M. Francis, A. Huang, B. Peng, J. E. Pintar, H. Ariga, and P. Cohen PAPA-1 Is a Nuclear Binding Partner of IGFBP-2 and Modulates Its Growth-Promoting Actions Mol. Endocrinol., February 1, 2009; 23(2): 169 - 175. [Abstract] [Full Text] [PDF]

				M A Velazquez, J Zaraza, A Oropeza, R Webb, and H Niemann The role of IGF1 in the in vivo production of bovine embryos from superovulated donors Reproduction, February 1, 2009; 137(2): 161 - 180. [Abstract] [Full Text] [PDF]

				B. M. Wolpin, J. A. Meyerhardt, A. T. Chan, K. Ng, J. A. Chan, K. Wu, M. N. Pollak, E. L. Giovannucci, and C. S. Fuchs Insulin, the Insulin-Like Growth Factor Axis, and Mortality in Patients With Nonmetastatic Colorectal Cancer J. Clin. Oncol., January 10, 2009; 27(2): 176 - 185. [Abstract] [Full Text] [PDF]

				M. D. Seferovic, R. Ali, H. Kamei, S. Liu, J. M. Khosravi, S. Nazarian, V. K. M. Han, C. Duan, and M. B. Gupta Hypoxia and Leucine Deprivation Induce Human Insulin-Like Growth Factor Binding Protein-1 Hyperphosphorylation and Increase Its Biological Activity Endocrinology, January 1, 2009; 150(1): 220 - 231. [Abstract] [Full Text] [PDF]

				V. D. Winn, M. Gormley, A. C. Paquet, K. Kjaer-Sorensen, A. Kramer, K. K. Rumer, R. Haimov-Kochman, R.-F. Yeh, M. T. Overgaard, A. Varki, et al. Severe Preeclampsia-Related Changes in Gene Expression at the Maternal-Fetal Interface Include Sialic Acid-Binding Immunoglobulin-Like Lectin-6 and Pappalysin-2 Endocrinology, January 1, 2009; 150(1): 452 - 462. [Abstract] [Full Text] [PDF]

				C. Ganeff, G. Chatel, C. Munaut, F. Frankenne, J.-M. Foidart, and R. Winkler The IGF system in in-vitro human decidualization Mol. Hum. Reprod., January 1, 2009; 15(1): 27 - 38. [Abstract] [Full Text] [PDF]

				N. I. Bower, X. Li, R. Taylor, and I. A. Johnston Switching to fast growth: the insulin-like growth factor (IGF) system in skeletal muscle of Atlantic salmon J. Exp. Biol., December 15, 2008; 211(24): 3859 - 3870. [Abstract] [Full Text] [PDF]

				C. S. Fuchs, R. M. Goldberg, D. J. Sargent, J. A. Meyerhardt, B. M. Wolpin, E. M. Green, H. C. Pitot, and M. Pollak Plasma Insulin-like Growth Factors, Insulin-like Binding Protein-3, and Outcome in Metastatic Colorectal Cancer: Results from Intergroup Trial N9741 Clin. Cancer Res., December 15, 2008; 14(24): 8263 - 8269. [Abstract] [Full Text] [PDF]

				A. Kotronen, M. Lewitt, K. Hall, K. Brismar, and H. Yki-Jarvinen Insulin-Like Growth Factor Binding Protein 1 as a Novel Specific Marker of Hepatic Insulin Sensitivity J. Clin. Endocrinol. Metab., December 1, 2008; 93(12): 4867 - 4872. [Abstract] [Full Text] [PDF]

				M. C. Satterfield, K. Hayashi, G. Song, S. G. Black, F. W. Bazer, and T. E. Spencer Progesterone Regulates FGF10, MET, IGFBP1, and IGFBP3 in the Endometrium of the Ovine Uterus Biol Reprod, December 1, 2008; 79(6): 1226 - 1236. [Abstract] [Full Text] [PDF]

				S. B. Rho, S. M. Dong, S. Kang, S.-S. Seo, C. W. Yoo, D. O. Lee, J. S. Woo, and S.-Y. Park Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis Carcinogenesis, November 1, 2008; 29(11): 2106 - 2111. [Abstract] [Full Text] [PDF]

				A. I. So, R. J. Levitt, B. Eigl, L. Fazli, M. Muramaki, S. Leung, M. C.U. Cheang, T. O. Nielsen, M. Gleave, and M. Pollak Insulin-Like Growth Factor Binding Protein-2 Is a Novel Therapeutic Target Associated with Breast Cancer Clin. Cancer Res., November 1, 2008; 14(21): 6944 - 6954. [Abstract] [Full Text] [PDF]

				L. Laviola, A. Natalicchio, S. Perrini, and F. Giorgino Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E991 - E999. [Abstract] [Full Text] [PDF]

				S. M. Gehrig, J. G. Ryall, J. D. Schertzer, and G. S. Lynch Insulin-like growth factor-I analogue protects muscles of dystrophic mdx mice from contraction-mediated damage Exp Physiol, November 1, 2008; 93(11): 1190 - 1198. [Abstract] [Full Text] [PDF]

				M. M. Chitnis, J. S.P. Yuen, A. S. Protheroe, M. Pollak, and V. M. Macaulay The Type 1 Insulin-Like Growth Factor Receptor Pathway Clin. Cancer Res., October 15, 2008; 14(20): 6364 - 6370. [Abstract] [Full Text] [PDF]

				A. W. Roddam, N. E. Allen, P. Appleby, T. J. Key, L. Ferrucci, H. B. Carter, E. J. Metter, C. Chen, N. S. Weiss, A. Fitzpatrick, et al. Insulin-like Growth Factors, Their Binding Proteins, and Prostate Cancer Risk: Analysis of Individual Patient Data from 12 Prospective Studies Ann Intern Med, October 7, 2008; 149(7): 461 - 471. [Abstract] [Full Text] [PDF]

				E. Himpe, C. Degaillier, A. Coppens, and R. Kooijman Insulin-like growth factor-1 delays Fas-mediated apoptosis in human neutrophils through the phosphatidylinositol-3 kinase pathway J. Endocrinol., October 1, 2008; 199(1): 69 - 80. [Abstract] [Full Text] [PDF]

				D. Kiepe, A. Van Der Pas, S. Ciarmatori, L. Standker, B. Schutt, A. Hoeflich, U. Hugel, J. Oh, and B. Tonshoff Defined Carboxy-Terminal Fragments of Insulin-Like Growth Factor (IGF) Binding Protein-2 Exert Similar Mitogenic Activity on Cultured Rat Growth Plate Chondrocytes as IGF-I Endocrinology, October 1, 2008; 149(10): 4901 - 4911. [Abstract] [Full Text] [PDF]

				X. Sang, M. S. Curran, and A. W. Wood Paracrine Insulin-Like Growth Factor Signaling Influences Primordial Germ Cell Migration: In Vivo Evidence from the Zebrafish Model Endocrinology, October 1, 2008; 149(10): 5035 - 5042. [Abstract] [Full Text] [PDF]

				H. Ren, P. Yin, and C. Duan IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop J. Cell Biol., September 8, 2008; 182(5): 979 - 991. [Abstract] [Full Text] [PDF]

				D. Choi, K.-T. T. Nguyen, L. Wang, S. A. Schroer, A. Suzuki, T. W. Mak, and M. Woo Partial Deletion of Pten in the Hypothalamus Leads to Growth Defects that Cannot be Rescued by Exogenous Growth Hormone Endocrinology, September 1, 2008; 149(9): 4382 - 4386. [Abstract] [Full Text] [PDF]

				P. Haluska, J. M. Carboni, C. TenEyck, R. M. Attar, X. Hou, C. Yu, M. Sagar, T. W. Wong, M. M. Gottardis, and C. Erlichman HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924 Mol. Cancer Ther., September 1, 2008; 7(9): 2589 - 2598. [Abstract] [Full Text] [PDF]

				B. D. Rodgers and D. K. Garikipati Clinical, Agricultural, and Evolutionary Biology of Myostatin: A Comparative Review Endocr. Rev., August 1, 2008; 29(5): 513 - 534. [Abstract] [Full Text] [PDF]

				K. L. Gatford, J. A. Owens, S. Li, T. J. M. Moss, J. P. Newnham, J. R. G. Challis, and D. M. Sloboda Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E170 - E178. [Abstract] [Full Text] [PDF]

				N. Jansson, A. Nilsfelt, M. Gellerstedt, M. Wennergren, L. Rossander-Hulthen, T. L Powell, and T. Jansson Maternal hormones linking maternal body mass index and dietary intake to birth weight, Am. J. Clinical Nutrition, June 1, 2008; 87(6): 1743 - 1749. [Abstract] [Full Text] [PDF]

				A. Flood, V. Mai, R. Pfeiffer, L. Kahle, C. J. Rosen, E. Lanza, and A. Schatzkin Serum Concentrations of Insulin-Like Growth Factor and Insulin-Like Growth Factor Binding Protein 3 and Recurrent Colorectal Adenomas Cancer Epidemiol. Biomarkers Prev., June 1, 2008; 17(6): 1493 - 1498. [Abstract] [Full Text] [PDF]

				J. Ukropec, A. Penesova, M. Skopkova, M. Pura, M. Vlcek, Z. Radikova, R. Imrich, B. Ukropcova, M. Tajtakova, J. Koska, et al. Adipokine Protein Expression Pattern in Growth Hormone Deficiency Predisposes to the Increased Fat Cell Size and the Whole Body Metabolic Derangements J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2255 - 2262. [Abstract] [Full Text] [PDF]

				Y. Ning, A. G. P. Schuller, C. A. Conover, and J. E. Pintar Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in Vivo Mol. Endocrinol., May 1, 2008; 22(5): 1213 - 1225. [Abstract] [Full Text] [PDF]

				R. M. Martin, D. Gunnell, E. Whitley, A. Nicolaides, M. Griffin, N. Georgiou, G. Davey Smith, S. Ebrahim, and J. M. P. Holly Associations of Insulin-Like Growth Factor (IGF)-I, IGF-II, IGF Binding Protein (IGFBP)-2 and IGFBP-3 with Ultrasound Measures of Atherosclerosis and Plaque Stability in an Older Adult Population J. Clin. Endocrinol. Metab., April 1, 2008; 93(4): 1331 - 1338. [Abstract] [Full Text] [PDF]

				G. Zappala, C. Elbi, J. Edwards, J. Gorenstein, M. M. Rechler, and N. Bhattacharyya Induction of Apoptosis in Human Prostate Cancer Cells by Insulin-Like Growth Factor Binding Protein-3 Does Not Require Binding to Retinoid X Receptor-{alpha} Endocrinology, April 1, 2008; 149(4): 1802 - 1812. [Abstract] [Full Text] [PDF]

				B. G. Hollier, J. A. Kricker, D. R. Van Lonkhuyzen, D. I. Leavesley, and Z. Upton Substrate-Bound Insulin-Like Growth Factor (IGF)-I-IGF Binding Protein-Vitronectin-Stimulated Breast Cell Migration Is Enhanced by Coactivation of the Phosphatidylinositide 3-Kinase/AKT Pathway by {alpha}v-Integrins and the IGF-I Receptor Endocrinology, March 1, 2008; 149(3): 1075 - 1090. [Abstract] [Full Text] [PDF]

				R. L. Chen, N. A. Kassem, M. Sadeghi, and J. E. Preston Insulin-Like Growth Factor-II Uptake Into Choroid Plexus and Brain of Young and Old Sheep J Gerontol A Biol Sci Med Sci, February 1, 2008; 63(2): 141 - 148. [Abstract] [Full Text] [PDF]

				T. G. Harris, R. D. Burk, H. Yu, H. Minkoff, L. S. Massad, D. H. Watts, Y. Zhong, S. Gange, R. C. Kaplan, K. Anastos, et al. Insulin-Like Growth Factor Axis and Oncogenic Human Papillomavirus Natural History Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 245 - 248. [Abstract] [Full Text] [PDF]

				P. D. Ryan and P. E. Goss The Emerging Role of the Insulin-Like Growth Factor Pathway as a Therapeutic Target in Cancer Oncologist, January 1, 2008; 13(1): 16 - 24. [Abstract] [Full Text] [PDF]

				J. W. B de Groot, B. Rikhof, J. van Doorn, H. J G Bilo, M. A Alleman, A. H Honkoop, and W. T A van der Graaf Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases Endocr. Relat. Cancer, December 1, 2007; 14(4): 979 - 993. [Abstract] [Full Text] [PDF]

				J. I-J. Leu and D. L. George Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria Genes & Dev., December 1, 2007; 21(23): 3095 - 3109. [Abstract] [Full Text] [PDF]

				J. Paquette, B. Bessette, E. Ledru, and C. Deal Identification of Upstream Stimulatory Factor Binding Sites in the Human IGFBP3 Promoter and Potential Implication of Adjacent Single-Nucleotide Polymorphisms and Responsiveness to Insulin Endocrinology, December 1, 2007; 148(12): 6007 - 6018. [Abstract] [Full Text] [PDF]

				F. R. Santer, B. Moser, G. A. Spoden, P. Jansen-Durr, and W. Zwerschke Human papillomavirus type 16 E7 oncoprotein inhibits apoptosis mediated by nuclear insulin-like growth factor-binding protein-3 by enhancing its ubiquitin/proteasome-dependent degradation Carcinogenesis, December 1, 2007; 28(12): 2511 - 2520. [Abstract] [Full Text] [PDF]

				V. Misra, H. Lee, A. Singh, K. Huang, R. K. Thimmulappa, W. Mitzner, S. Biswal, and C. G. Tankersley Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes Physiol Genomics, November 14, 2007; 31(3): 429 - 440. [Abstract] [Full Text] [PDF]

				S. H. Siahpush, T. L. Vaughan, J. N. Lampe, R. Freeman, S. Lewis, R. D. Odze, P. L. Blount, K. Ayub, P. S. Rabinovitch, B. J. Reid, et al. Longitudinal Study of Insulin-like Growth Factor, Insulin-like Growth Factor Binding Protein-3, and their Polymorphisms: Risk of Neoplastic Progression in Barrett's Esophagus Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2387 - 2395. [Abstract] [Full Text] [PDF]

				K. S. Kim, Y. B. Seu, S.-H. Baek, M. J. Kim, K. J. Kim, J. H. Kim, and J.-R. Kim Induction of Cellular Senescence by Insulin-like Growth Factor Binding Protein-5 through a p53-dependent Mechanism Mol. Biol. Cell, November 1, 2007; 18(11): 4543 - 4552. [Abstract] [Full Text] [PDF]

				L. J. Schedlich, A. Muthukaruppan, M. K. O'Han, and R. C. Baxter Insulin-Like Growth Factor Binding Protein-5 Interacts with the Vitamin D Receptor and Modulates the Vitamin D Response in Osteoblasts Mol. Endocrinol., October 1, 2007; 21(10): 2378 - 2390. [Abstract] [Full Text] [PDF]

				J. D. Schertzer, S. M. Gehrig, J. G. Ryall, and G. S. Lynch Modulation of Insulin-like Growth Factor (IGF)-I and IGF-Binding Protein Interactions Enhances Skeletal Muscle Regeneration and Ameliorates the Dystrophic Pathology in mdx Mice Am. J. Pathol., October 1, 2007; 171(4): 1180 - 1188. [Abstract] [Full Text] [PDF]

				K. E. Govoni, S. K. Lee, Y.-S. Chung, R. R. Behringer, J. E. Wergedal, D. J. Baylink, and S. Mohan Disruption of insulin-like growth factor-I expression in type II{alpha}I collagen-expressing cells reduces bone length and width in mice Physiol Genomics, August 20, 2007; 30(3): 354 - 362. [Abstract] [Full Text] [PDF]

				P. Fu, J. A. Thompson, and L. A. Bach Promotion of Cancer Cell Migration: AN INSULIN-LIKE GROWTH FACTOR (IGF)-INDEPENDENT ACTION OF IGF-BINDING PROTEIN-6 J. Biol. Chem., August 3, 2007; 282(31): 22298 - 22306. [Abstract] [Full Text] [PDF]

				M. E. Graham, D. M. Kilby, S. M. Firth, P. J. Robinson, and R. C. Baxter The in Vivo Phosphorylation and Glycosylation of Human Insulin-like Growth Factor-binding Protein-5 Mol. Cell. Proteomics, August 1, 2007; 6(8): 1392 - 1405. [Abstract] [Full Text] [PDF]

				J. Lee, J. M. Basak, S. Demehri, and R. Kopan Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes Development, August 1, 2007; 134(15): 2795 - 2806. [Abstract] [Full Text] [PDF]

				S. M. Dunlap, J. Celestino, H. Wang, R. Jiang, E. C. Holland, G. N. Fuller, and W. Zhang Insulin-like growth factor binding protein 2 promotes glioma development and progression PNAS, July 10, 2007; 104(28): 11736 - 11741. [Abstract] [Full Text] [PDF]

				T. Fukushima, T. Tezuka, T. Shimomura, S. Nakano, and H. Kataoka Silencing of Insulin-like Growth Factor-binding Protein-2 in Human Glioblastoma Cells Reduces Both Invasiveness and Expression of Progression-associated Gene CD24 J. Biol. Chem., June 22, 2007; 282(25): 18634 - 18644. [Abstract] [Full Text] [PDF]

				C. Lofqvist, J. Chen, K. M. Connor, A. C. H. Smith, C. M. Aderman, N. Liu, J. E. Pintar, T. Ludwig, A. Hellstrom, and L. E. H. Smith From the Cover: IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth PNAS, June 19, 2007; 104(25): 10589 - 10594. [Abstract] [Full Text] [PDF]

				K.-H. Chang, T. Chan-Ling, E. L. McFarland, A. Afzal, H. Pan, L. C. Baxter, L. C. Shaw, S. Caballero, N. Sengupta, S. L. Calzi, et al. IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development PNAS, June 19, 2007; 104(25): 10595 - 10600. [Abstract] [Full Text] [PDF]

				S. G. Murali, X. Liu, D. W. Nelson, A. K. Hull, M. Grahn, M. K. Clayton, J. E. Pintar, and D. M. Ney Intestinotrophic effects of exogenous IGF-I are not diminished in IGF binding protein-5 knockout mice Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2144 - R2150. [Abstract] [Full Text] [PDF]

				A. Denley, J. M. Carroll, G. V. Brierley, L. Cosgrove, J. Wallace, B. Forbes, and C. T. Roberts Jr. Differential Activation of Insulin Receptor Substrates 1 and 2 by Insulin-Like Growth Factor-Activated Insulin Receptors Mol. Cell. Biol., May 15, 2007; 27(10): 3569 - 3577. [Abstract] [Full Text] [PDF]

				L. S. Laursen, K. Kjaer-Sorensen, M. H. Andersen, and C. Oxvig Regulation of Insulin-Like Growth Factor (IGF) Bioactivity by Sequential Proteolytic Cleavage of IGF Binding Protein-4 and -5 Mol. Endocrinol., May 1, 2007; 21(5): 1246 - 1257. [Abstract] [Full Text] [PDF]

				Y. Ning, B. Hoang, A. G. P. Schuller, T. P. Cominski, M.-S. Hsu, T. L. Wood, and J. E. Pintar Delayed Mammary Gland Involution in Mice with Mutation of the Insulin-Like Growth Factor Binding Protein 5 Gene Endocrinology, May 1, 2007; 148(5): 2138 - 2147. [Abstract] [Full Text] [PDF]

				J. L. Martin and R. C. Baxter Expression of Insulin-Like Growth Factor Binding Protein-2 by MCF-7 Breast Cancer Cells Is Regulated through the Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Pathway Endocrinology, May 1, 2007; 148(5): 2532 - 2541. [Abstract] [Full Text] [PDF]

				C. Gyrup, M. Christiansen, and C. Oxvig Quantification of Proteolytically Active Pregnancy-Associated Plasma Protein-A with an Assay Based on Quenched Fluorescence Clin. Chem., May 1, 2007; 53(5): 947 - 954. [Abstract] [Full Text] [PDF]

				S. Mukherjee and C. Guidry The Insulin-Like Growth Factor System Modulates Retinal Pigment Epithelial Cell Tractional Force Generation Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1892 - 1899. [Abstract] [Full Text] [PDF]

				J. L. Eiseman, J. Guo, R. K. Ramanathan, C. P. Belani, D. B. Solit, H. I. Scher, S. P. Ivy, E. G. Zuhowski, and M. J. Egorin Evaluation of Plasma Insulin-like Growth Factor Binding Protein 2 and Her-2 Extracellular Domain as Biomarkers for 17-Allylamino-17-Demethoxygeldanamycin Treatment of Adult Patients with Advanced Solid Tumors Clin. Cancer Res., April 1, 2007; 13(7): 2121 - 2127. [Abstract] [Full Text] [PDF]

				Y. Yin, J. Ni, M. Chen, M. A. DiMaggio, Y. Guo, and S. Yeh The Therapeutic and Preventive Effect of RRR-{alpha}-Vitamin E Succinate on Prostate Cancer via Induction of Insulin-Like Growth Factor Binding Protein-3 Clin. Cancer Res., April 1, 2007; 13(7): 2271 - 2280. [Abstract] [Full Text] [PDF]

				O. Shynlova, P. Tsui, A. Dorogin, B. L. Langille, and S. J. Lye Insulin-like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy in the Rat Biol Reprod, April 1, 2007; 76(4): 571 - 578. [Abstract] [Full Text] [PDF]

				G. Walker, K. MacLeod, A. R.W. Williams, D. A. Cameron, J. F. Smyth, and S. P. Langdon Insulin-like Growth Factor Binding Proteins IGFBP3, IGFBP4, and IGFBP5 Predict Endocrine Responsiveness in Patients with Ovarian Cancer Clin. Cancer Res., March 1, 2007; 13(5): 1438 - 1444. [Abstract] [Full Text] [PDF]

				K. Pazaitou-Panayiotou, T. Kelesidis, I. Kelesidis, A. Kaprara, J. Blakeman, I. Vainas, A. Mpousoulegas, C. J Williams, and C. Mantzoros Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer Eur. J. Endocrinol., February 1, 2007; 156(2): 187 - 194. [Abstract] [Full Text] [PDF]

				S. B. Wheatcroft, M. T. Kearney, A. M. Shah, V. A. Ezzat, J. R. Miell, M. Modo, S. C.R. Williams, W. P. Cawthorn, G. Medina-Gomez, A. Vidal-Puig, et al. IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance Diabetes, February 1, 2007; 56(2): 285 - 294. [Abstract] [Full Text] [PDF]

				C. A. Borgono, I. P. Michael, J. L. V. Shaw, L.-Y. Luo, M. C. Ghosh, A. Soosaipillai, L. Grass, D. Katsaros, and E. P. Diamandis Expression and Functional Characterization of the Cancer-related Serine Protease, Human Tissue Kallikrein 14 J. Biol. Chem., January 26, 2007; 282(4): 2405 - 2422. [Abstract] [Full Text] [PDF]

				C. M A Reijnders, N. Bravenboer, A. M Tromp, M. A Blankenstein, and P. Lips Effect of mechanical loading on insulin-like growth factor-I gene expression in rat tibia J. Endocrinol., January 1, 2007; 192(1): 131 - 140. [Abstract] [Full Text] [PDF]

				T. Degenhardt, M. Matilainen, K.-H. Herzig, T. W. Dunlop, and C. Carlberg The Insulin-like Growth Factor-binding Protein 1 Gene Is a Primary Target of Peroxisome Proliferator-activated Receptors J. Biol. Chem., December 22, 2006; 281(51): 39607 - 39619. [Abstract] [Full Text] [PDF]

				C. Chen, R. Freeman, L. F. Voigt, A. Fitzpatrick, S. R. Plymate, and N. S. Weiss Prostate Cancer Risk in Relation to Selected Genetic Polymorphisms in Insulin-like Growth Factor-I, Insulin-like Growth Factor Binding Protein-3, and Insulin-like Growth Factor-I Receptor Cancer Epidemiol. Biomarkers Prev., December 1, 2006; 15(12): 2461 - 2466. [Abstract] [Full Text] [PDF]