Genetic Analysis of the Mammalian Transforming Growth Factor-ß Superfamily
Hua Chang,
Chester W. Brown and
Martin M. Matzuk
Departments of Pathology (H.C., M.M.M.), Molecular and Human Genetics (C.W.B., M.M.M.), Molecular and Cellular Biology (M.M.M.), and Pediatrics (C.W.B.), and Program in Developmental Biology (H.C., M.M.M.), Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030
Correspondence: Address all correspondence and requests for reprints to: Martin M. Matzuk, M.D., Ph.D., The Stuart A. Wallace Chair and Professor, Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030. E-mail: mmatzuk{at}bcm.tmc.edu
Members of the TGF-ß superfamily, which includes TGF-ßs,growth differentiation factors, bone morphogenetic proteins,activins, inhibins, and glial cell line-derived neurotrophicfactor, are synthesized as prepropeptide precursors and thenprocessed and secreted as homodimers or heterodimers. Most ligandsof the family signal through transmembrane serine/threoninekinase receptors and SMAD proteins to regulate cellular functions.Many studies have reported the characterization of knockoutand knock-in transgenic mice as well as humans or other mammalswith naturally occurring genetic mutations in superfamily membersor their regulatory proteins. These investigations have revealedthat TGF-ß superfamily ligands, receptors, SMADs,and upstream and downstream regulators function in diverse developmentaland physiological pathways. This review attempts to collateand integrate the extensive body of in vivo mammalian studiesproduced over the last decade.
This article has been cited by other articles:
T. Fei, K. Xia, Z. Li, B. Zhou, S. Zhu, H. Chen, J. Zhang, Z. Chen, H. Xiao, J.-D. J. Han, et al. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination
Genome Res.,
January 1, 2010;
20(1):
36 - 44.
[Abstract][Full Text][PDF]
Q. Li, S. Rajanahally, M. A. Edson, and M. M. Matzuk Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15
Mol. Hum. Reprod.,
December 1, 2009;
15(12):
779 - 788.
[Abstract][Full Text][PDF]
S. G. Hillier Paracrine support of ovarian stimulation
Mol. Hum. Reprod.,
December 1, 2009;
15(12):
843 - 850.
[Abstract][Full Text][PDF]
V. L Dias, E. Rajpert-De Meyts, R. McLachlan, and K. L. Loveland Analysis of activin/TGFB-signaling modulators within the normal and dysfunctional adult human testis reveals evidence of altered signaling capacity in a subset of seminomas
Reproduction,
November 1, 2009;
138(5):
801 - 811.
[Abstract][Full Text][PDF]
Y. Y. Wan and R. A. Flavell How Diverse--CD4 Effector T Cells and their Functions
J Mol Cell Biol,
October 1, 2009;
1(1):
20 - 36.
[Abstract][Full Text][PDF]
N Hoggard, M Cruickshank, K M Moar, P Barrett, S Bashir, and J D B Miller Inhibin {beta}B expression in murine adipose tissue and its regulation by leptin, insulin and dexamethasone
J. Mol. Endocrinol.,
October 1, 2009;
43(4):
171 - 177.
[Abstract][Full Text][PDF]
M. A. Edson, A. K. Nagaraja, and M. M. Matzuk The Mammalian Ovary from Genesis to Revelation
Endocr. Rev.,
October 1, 2009;
30(6):
624 - 712.
[Abstract][Full Text][PDF]
C. Ruoss, A. Tadros, T. O'Shea, J. McFarlane, and G. Almahbobi Ovarian follicle development in Booroola sheep exhibiting impaired bone morphogenetic protein signalling pathway
Reproduction,
October 1, 2009;
138(4):
689 - 696.
[Abstract][Full Text][PDF]
Y. Wang, P. K Nicholls, P. G Stanton, C. A Harrison, M. Sarraj, R. B Gilchrist, J. K Findlay, and P. G Farnworth Extra-ovarian expression and activity of growth differentiation factor 9
J. Endocrinol.,
September 1, 2009;
202(3):
419 - 430.
[Abstract][Full Text][PDF]
L. Li, J. J. Shen, J. C. Bournat, L. Huang, A. Chattopadhyay, Z. Li, C. Shaw, B. H. Graham, and C. W. Brown Activin Signaling: Effects on Body Composition and Mitochondrial Energy Metabolism
Endocrinology,
August 1, 2009;
150(8):
3521 - 3529.
[Abstract][Full Text][PDF]
F.-T. Shi, A. P. Cheung, and P. C. K. Leung Growth Differentiation Factor 9 Enhances Activin A-Induced Inhibin B Production in Human Granulosa Cells
Endocrinology,
August 1, 2009;
150(8):
3540 - 3546.
[Abstract][Full Text][PDF]
J. L Juengel, N. L Hudson, M. Berg, K. Hamel, P. Smith, S. B Lawrence, L. Whiting, and K. P McNatty Effects of active immunization against growth differentiation factor 9 and/or bone morphogenetic protein 15 on ovarian function in cattle
Reproduction,
July 1, 2009;
138(1):
107 - 114.
[Abstract][Full Text][PDF]
Q. Yang, S.-P. Chen, X.-P. Zhang, H. Wang, C. Zhu, and H.-Y. Lin Smurf2 Participates in Human Trophoblast Cell Invasion by Inhibiting TGF-{beta} Type I Receptor
J. Histochem. Cytochem.,
June 1, 2009;
57(6):
605 - 612.
[Abstract][Full Text][PDF]
M. Orisaka, J.-Y. Jiang, S. Orisaka, F. Kotsuji, and B. K. Tsang Growth Differentiation Factor 9 Promotes Rat Preantral Follicle Growth by Up-Regulating Follicular Androgen Biosynthesis
Endocrinology,
June 1, 2009;
150(6):
2740 - 2748.
[Abstract][Full Text][PDF]
K. H. Wrighton, X. Lin, P. B. Yu, and X.-H. Feng Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors
J. Biol. Chem.,
April 10, 2009;
284(15):
9755 - 9763.
[Abstract][Full Text][PDF]
M. Murakami, H. Kawachi, K. Ogawa, Y. Nishino, and M. Funaba Receptor expression modulates the specificity of transforming growth factor-beta signaling pathways.
Genes Cells,
April 1, 2009;
14(4):
469 - 482.
[Abstract][Full Text][PDF]
B R Klass, A O Grobbelaar, and K J Rolfe Transforming growth factor {beta}1 signalling, wound healing and repair: a multifunctional cytokine with clinical implications for wound repair, a delicate balance
Postgrad. Med. J.,
January 1, 2009;
85(999):
9 - 14.
[Abstract][Full Text][PDF]
Q. Li, S. A. Pangas, C. J. Jorgez, J. M. Graff, M. Weinstein, and M. M. Matzuk Redundant Roles of SMAD2 and SMAD3 in Ovarian Granulosa Cells In Vivo
Mol. Cell. Biol.,
December 1, 2008;
28(23):
7001 - 7011.
[Abstract][Full Text][PDF]
C. J. McIntosh, S. Lun, S. Lawrence, A. H. Western, K. P. McNatty, and J. L. Juengel The Proregion of Mouse BMP15 Regulates the Cooperative Interactions of BMP15 and GDF9
Biol Reprod,
November 1, 2008;
79(5):
889 - 896.
[Abstract][Full Text][PDF]
G. Xu, S. Bernaudo, G. Fu, D. Y. Lee, B. B. Yang, and C. Peng Cyclin G2 Is Degraded through the Ubiquitin-Proteasome Pathway and Mediates the Antiproliferative Effect of Activin Receptor-like Kinase 7
Mol. Biol. Cell,
November 1, 2008;
19(11):
4968 - 4979.
[Abstract][Full Text][PDF]
F. Ghannad, D. Nica, M. I. Garcia Fulle, D. Grenier, E. E. Putnins, S. Johnston, A. Eslami, L. Koivisto, G. Jiang, M. D. McKee, et al. Absence of {alpha}v{beta}6 Integrin Is Linked to Initiation and Progression of Periodontal Disease
Am. J. Pathol.,
May 1, 2008;
172(5):
1271 - 1286.
[Abstract][Full Text][PDF]
A. L. Blount, J. M. Vaughan, W. W. Vale, and L. M. Bilezikjian A Smad-binding Element in Intron 1 Participates in Activin-dependent Regulation of the Follistatin Gene
J. Biol. Chem.,
March 14, 2008;
283(11):
7016 - 7026.
[Abstract][Full Text][PDF]
S.-Y. Lin, R. G. Craythorn, A. E. O'Connor, M. M. Matzuk, J. E. Girling, J. R. Morrison, and D. M. de Kretser Female Infertility and Disrupted Angiogenesis Are Actions of Specific Follistatin Isoforms
Mol. Endocrinol.,
February 1, 2008;
22(2):
415 - 429.
[Abstract][Full Text][PDF]
H. E. McMahon, S. Sharma, and S. Shimasaki Phosphorylation of Bone Morphogenetic Protein-15 and Growth and Differentiation Factor-9 Plays a Critical Role in Determining Agonistic or Antagonistic Functions
Endocrinology,
February 1, 2008;
149(2):
812 - 817.
[Abstract][Full Text][PDF]
V. Dias, S. Meachem, E. Rajpert-De Meyts, R. McLachlan, U. Manuelpillai, and K.L. Loveland Activin receptor subunits in normal and dysfunctional adult human testis
Hum. Reprod.,
February 1, 2008;
23(2):
412 - 420.
[Abstract][Full Text][PDF]
L. J Spicer, P. Y Aad, D. T Allen, S. Mazerbourg, A. H Payne, and A. J Hsueh Growth Differentiation Factor 9 (GDF9) Stimulates Proliferation and Inhibits Steroidogenesis by Bovine Theca Cells: Influence of Follicle Size on Responses to GDF9
Biol Reprod,
February 1, 2008;
78(2):
243 - 253.
[Abstract][Full Text][PDF]
S. O. Park, Y. J. Lee, T. Seki, K.-H. Hong, N. Fliess, Z. Jiang, A. Park, X. Wu, V. Kaartinen, B. L. Roman, et al. ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2
Blood,
January 15, 2008;
111(2):
633 - 642.
[Abstract][Full Text][PDF]
S. A. Pangas, X. Li, L. Umans, A. Zwijsen, D. Huylebroeck, C. Gutierrez, D. Wang, J. F. Martin, S. P. Jamin, R. R. Behringer, et al. Conditional Deletion of Smad1 and Smad5 in Somatic Cells of Male and Female Gonads Leads to Metastatic Tumor Development in Mice
Mol. Cell. Biol.,
January 1, 2008;
28(1):
248 - 257.
[Abstract][Full Text][PDF]
F. J Diaz, K. Sugiura, and J. J Eppig Regulation of Pcsk6 Expression During the Preantral to Antral Follicle Transition in Mice: Opposing Roles of FSH and Oocytes
Biol Reprod,
January 1, 2008;
78(1):
176 - 183.
[Abstract][Full Text][PDF]
F. Cillo, T. A L Brevini, S. Antonini, A. Paffoni, G. Ragni, and F. Gandolfi Association between human oocyte developmental competence and expression levels of some cumulus genes
Reproduction,
November 1, 2007;
134(5):
645 - 650.
[Abstract][Full Text][PDF]
P. G. Farnworth, Y. Wang, R. Escalona, P. Leembruggen, G. T. Ooi, and J. K. Findlay Transforming Growth Factor-{beta} Blocks Inhibin Binding to Different Target Cell Types in a Context-Dependent Manner through Dual Mechanisms Involving Betaglycan
Endocrinology,
November 1, 2007;
148(11):
5355 - 5368.
[Abstract][Full Text][PDF]
Q. Li, J. M. Graff, A. E. O'Connor, K. L. Loveland, and M. M. Matzuk SMAD3 Regulates Gonadal Tumorigenesis
Mol. Endocrinol.,
October 1, 2007;
21(10):
2472 - 2486.
[Abstract][Full Text][PDF]
S. A. Pangas, C. J. Jorgez, M. Tran, J. Agno, X. Li, C. W. Brown, T. R. Kumar, and M. M. Matzuk Intraovarian Activins Are Required for Female Fertility
Mol. Endocrinol.,
October 1, 2007;
21(10):
2458 - 2471.
[Abstract][Full Text][PDF]
S. H. Wrzesinski, Y. Y. Wan, and R. A. Flavell Transforming Growth Factor-{beta} and the Immune Response: Implications for Anticancer Therapy
Clin. Cancer Res.,
September 15, 2007;
13(18):
5262 - 5270.
[Abstract][Full Text][PDF]
F. Dai, C. Chang, X. Lin, P. Dai, L. Mei, and X.-H. Feng Erbin Inhibits Transforming Growth Factor {beta} Signaling through a Novel Smad-Interacting Domain
Mol. Cell. Biol.,
September 1, 2007;
27(17):
6183 - 6194.
[Abstract][Full Text][PDF]
Q. Li, R. Kumar, K. Underwood, A. E. O'Connor, K. L. Loveland, J. S. Seehra, and M. M. Matzuk Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein
Mol. Hum. Reprod.,
September 1, 2007;
13(9):
675 - 683.
[Abstract][Full Text][PDF]
Y.-T. Wu, L. Tang, J. Cai, X.-E Lu, J. Xu, X.-M. Zhu, Q. Luo, and H.-F. Huang High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development
Hum. Reprod.,
June 1, 2007;
22(6):
1526 - 1531.
[Abstract][Full Text][PDF]
H. Wang and B. K Tsang Nodal signalling and apoptosis
Reproduction,
May 1, 2007;
133(5):
847 - 853.
[Abstract][Full Text][PDF]
G. Avila, I. M. Medina, E. Jimenez, G. Elizondo, and C. I. Aguilar Transforming growth factor-beta1 decreases cardiac muscle L-type Ca2+ current and charge movement by acting on the Cav1.2 mRNA
Am J Physiol Heart Circ Physiol,
January 1, 2007;
292(1):
H622 - H631.
[Abstract][Full Text][PDF]
X. Gueripel, V. Brun, and A. Gougeon Oocyte Bone Morphogenetic Protein 15, but not Growth Differentiation Factor 9, Is Increased During Gonadotropin-Induced Follicular Development in the Immature Mouse and Is Associated with Cumulus Oophorus Expansion
Biol Reprod,
December 1, 2006;
75(6):
836 - 843.
[Abstract][Full Text][PDF]
H. Zhang, J. S. Bailey, D. Coss, B. Lin, R. Tsutsumi, M. A. Lawson, P. L. Mellon, and N. J. G. Webster Activin Modulates the Transcriptional Response of LssT2 Cells to Gonadotropin-Releasing Hormone and Alters Cellular Proliferation
Mol. Endocrinol.,
November 1, 2006;
20(11):
2909 - 2930.
[Abstract][Full Text][PDF]
C. Chang, A. H. Brivanlou, and R. M. Harland Function of the Two Xenopus Smad4s in Early Frog Development
J. Biol. Chem.,
October 13, 2006;
281(41):
30794 - 30803.
[Abstract][Full Text][PDF]
M. Orisaka, S. Orisaka, J.-Y. Jiang, J. Craig, Y. Wang, F. Kotsuji, and B. K. Tsang Growth Differentiation Factor 9 Is Antiapoptotic during Follicular Development from Preantral to Early Antral Stage
Mol. Endocrinol.,
October 1, 2006;
20(10):
2456 - 2468.
[Abstract][Full Text][PDF]
A. Ishimura, J. K. Ng, M. Taira, S. G. Young, and S.-I. Osada Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor {beta} signaling
Development,
October 1, 2006;
133(19):
3919 - 3928.
[Abstract][Full Text][PDF]
K.R. Barnett, C. Schilling, C.R. Greenfeld, D. Tomic, and J.A. Flaws Ovarian follicle development and transgenic mouse models
Hum. Reprod. Update,
September 1, 2006;
12(5):
537 - 555.
[Abstract][Full Text][PDF]
A. Drummond and J. Findlay Focus on TGF-{beta} signalling.
Reproduction,
August 1, 2006;
132(2):
177 - 178.
[Full Text][PDF]
S J. Lin, T. F Lerch, R. W Cook, T. S Jardetzky, and T. K Woodruff The structural basis of TGF-{beta}, bone morphogenetic protein, and activin ligand binding.
Reproduction,
August 1, 2006;
132(2):
179 - 190.
[Abstract][Full Text][PDF]
P. G Knight and C. Glister TGF-{beta} superfamily members and ovarian follicle development.
Reproduction,
August 1, 2006;
132(2):
191 - 206.
[Abstract][Full Text][PDF]
L. M Bilezikjian, A. L Blount, C. J Donaldson, and W. W Vale Pituitary actions of ligands of the TGF-{beta} family: activins and inhibins.
Reproduction,
August 1, 2006;
132(2):
207 - 215.
[Abstract][Full Text][PDF]
R. L Jones, C. Stoikos, J. K Findlay, and L. A Salamonsen TGF-{beta} superfamily expression and actions in the endometrium and placenta.
Reproduction,
August 1, 2006;
132(2):
217 - 232.
[Abstract][Full Text][PDF]
C. Itman, S. Mendis, B. Barakat, and K. L. Loveland All in the family: TGF-{beta} family action in testis development.
Reproduction,
August 1, 2006;
132(2):
233 - 246.
[Abstract][Full Text][PDF]
E.K. Moses, E. Fitzpatrick, K.A. Freed, T.D. Dyer, S. Forrest, K. Elliott, M.P. Johnson, J. Blangero, and S.P. Brennecke Objective prioritization of positional candidate genes at a quantitative trait locus for pre-eclampsia on 2q22
Mol. Hum. Reprod.,
August 1, 2006;
12(8):
505 - 512.
[Abstract][Full Text][PDF]
S. E. Matsuo, S. G. Leoni, A. Colquhoun, and E. T. Kimura Transforming growth factor-{beta}1 and activin A generate antiproliferative signaling in thyroid cancer cells.
J. Endocrinol.,
July 1, 2006;
190(1):
141 - 150.
[Abstract][Full Text][PDF]
P. G. Farnworth, P. G. Stanton, Y. Wang, R. Escalona, J. K. Findlay, and G. T. Ooi Inhibins Differentially Antagonize Activin and Bone Morphogenetic Protein Action in a Mouse Adrenocortical Cell Line
Endocrinology,
July 1, 2006;
147(7):
3462 - 3471.
[Abstract][Full Text][PDF]
S. Mazerbourg and A. J.W. Hsueh Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands
Hum. Reprod. Update,
July 1, 2006;
12(4):
373 - 383.
[Abstract][Full Text][PDF]
W. Xia, D. D. Mruk, W. M. Lee, and C. Y. Cheng Differential Interactions between Transforming Growth Factor-beta3/TbetaR1, TAB1, and CD2AP Disrupt Blood-Testis Barrier and Sertoli-Germ Cell Adhesion
J. Biol. Chem.,
June 16, 2006;
281(24):
16799 - 16813.
[Abstract][Full Text][PDF]
S. A. Pangas, X. Li, E. J. Robertson, and M. M. Matzuk Premature Luteinization and Cumulus Cell Defects in Ovarian-Specific Smad4 Knockout Mice
Mol. Endocrinol.,
June 1, 2006;
20(6):
1406 - 1422.
[Abstract][Full Text][PDF]
R. Li, A. Rosendahl, G. Brodin, A. M. Cheng, A. Ahgren, C. Sundquist, S. Kulkarni, T. Pawson, C.-H. Heldin, and R. L. Heuchel Deletion of Exon I of SMAD7 in Mice Results in Altered B Cell Responses.
J. Immunol.,
June 1, 2006;
176(11):
6777 - 6784.
[Abstract][Full Text][PDF]
P. Laissue, S. Christin-Maitre, P. Touraine, F. Kuttenn, O. Ritvos, K. Aittomaki, N. Bourcigaux, L. Jacquesson, P. Bouchard, R. Frydman, et al. Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.
Eur. J. Endocrinol.,
May 1, 2006;
154(5):
739 - 744.
[Abstract][Full Text][PDF]
H. H.-C. Yao, J. Aardema, and K. Holthusen Sexually Dimorphic Regulation of Inhibin Beta B in Establishing Gonadal Vasculature in Mice
Biol Reprod,
May 1, 2006;
74(5):
978 - 983.
[Abstract][Full Text][PDF]
G. Xu, H. Zhou, Q. Wang, N. Auersperg, and C. Peng Activin Receptor-Like Kinase 7 Induces Apoptosis through Up-Regulation of Bax and Down-Regulation of Xiap in Normal and Malignant Ovarian Epithelial Cell Lines
Mol. Cancer Res.,
April 1, 2006;
4(4):
235 - 246.
[Abstract][Full Text][PDF]
P. G Farnworth, Y. Wang, P. Leembruggen, G. T Ooi, C. Harrison, D. M Robertson, and J. K Findlay Rodent adrenocortical cells display high affinity binding sites and proteins for inhibin A, and express components required for autocrine signalling by activins and bone morphogenetic proteins.
J. Endocrinol.,
March 1, 2006;
188(3):
451 - 465.
[Abstract][Full Text][PDF]
J. L Juengel, K. L Reader, A. H Bibby, S. Lun, I. Ross, L. J Haydon, and K. P McNatty The role of bone morphogenetic proteins 2, 4, 6 and 7 during ovarian follicular development in sheep: contrast to rat.
Reproduction,
March 1, 2006;
131(3):
501 - 513.
[Abstract][Full Text][PDF]
A. Roy and M. M Matzuk Deconstructing mammalian reproduction: using knockouts to define fertility pathways
Reproduction,
February 1, 2006;
131(2):
207 - 219.
[Abstract][Full Text][PDF]
S A Abdalla and M Letarte Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease
J. Med. Genet.,
February 1, 2006;
43(2):
97 - 110.
[Abstract][Full Text][PDF]
C. Chen, S. M. Ware, A. Sato, D. E. Houston-Hawkins, R. Habas, M. M. Matzuk, M. M. Shen, and C. W. Brown The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo
Development,
January 15, 2006;
133(2):
319 - 329.
[Abstract][Full Text][PDF]
E. Clelland, G. Kohli, R. K. Campbell, S. Sharma, S. Shimasaki, and C. Peng Bone Morphogenetic Protein-15 in the Zebrafish Ovary: Complementary Deoxyribonucleic Acid Cloning, Genomic Organization, Tissue Distribution, and Role in Oocyte Maturation
Endocrinology,
January 1, 2006;
147(1):
201 - 209.
[Abstract][Full Text][PDF]
P. Bertolino, M. Deckers, F. Lebrin, and P. ten Dijke Transforming Growth Factor-{beta} Signal Transduction in Angiogenesis and Vascular Disorders
Chest,
December 1, 2005;
128(6_suppl):
585S - 590S.
[Abstract][Full Text][PDF]
P. Bertolino, M. Deckers, F. Lebrin, and P. ten Dijke Transforming Growth Factor-{beta} Signal Transduction in Angiogenesis and Vascular Disorders
Chest,
December 1, 2005;
128(6_suppl):
585S - 590S.
[Abstract][Full Text][PDF]
X. Ma, A. Reyna, S. K. Mani, M. M. Matzuk, and T. R. Kumar Impaired Male Sexual Behavior in Activin Receptor Type II Knockout Mice
Biol Reprod,
December 1, 2005;
73(6):
1182 - 1190.
[Abstract][Full Text][PDF]
T. Stasyk, A. Dubrovska, M. Lomnytska, I. Yakymovych, C. Wernstedt, C.-H. Heldin, U. Hellman, and S. Souchelnytskyi Phosphoproteome Profiling of Transforming Growth Factor (TGF)-{beta} Signaling: Abrogation of TGF{beta}1-dependent Phosphorylation of Transcription Factor-II-I (TFII-I) Enhances Cooperation of TFII-I and Smad3 in Transcription
Mol. Biol. Cell,
October 1, 2005;
16(10):
4765 - 4780.
[Abstract][Full Text][PDF]
S. Mazerbourg, K. Sangkuhl, C.-W. Luo, S. Sudo, C. Klein, and A. J. W. Hsueh Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic Analyses
J. Biol. Chem.,
September 16, 2005;
280(37):
32122 - 32132.
[Abstract][Full Text][PDF]
Y. Omori, K. Nakamura, S. Yamashita, H. Matsuda, T. Mizutani, K. Miyamoto, and T. Minegishi Effect of Follicle-Stimulating Hormone and Estrogen on the Expression of Betaglycan Messenger Ribonucleic Acid Levels in Cultured Rat Granulosa Cells
Endocrinology,
August 1, 2005;
146(8):
3379 - 3386.
[Abstract][Full Text][PDF]
J. Lu, Y. Wu, N. Sousa, and O. F. X. Almeida SMAD pathway mediation of BDNF and TGF{beta}2 regulation of proliferation and differentiation of hippocampal granule neurons
Development,
July 15, 2005;
132(14):
3231 - 3242.
[Abstract][Full Text][PDF]
T. Alliston, T. C. Ko, Y. Cao, Y.-Y. Liang, X.-H. Feng, C. Chang, and R. Derynck Repression of Bone Morphogenetic Protein and Activin-inducible Transcription by Evi-1
J. Biol. Chem.,
June 24, 2005;
280(25):
24227 - 24237.
[Abstract][Full Text][PDF]
G. Karlsson, Y. Liu, J. Larsson, M.-J. Goumans, J.-S. Lee, S. S. Thorgeirsson, M. Ringner, and S. Karlsson Gene expression profiling demonstrates that TGF-{beta}1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-{beta} signaling
Physiol Genomics,
May 11, 2005;
21(3):
396 - 403.
[Abstract][Full Text][PDF]
B. Qiao, S. R. Padilla, and P. D. Benya Transforming Growth Factor (TGF)-{beta}-activated Kinase 1 Mimics and Mediates TGF-{beta}-induced Stimulation of Type II Collagen Synthesis in Chondrocytes Independent of Col2a1 Transcription and Smad3 Signaling
J. Biol. Chem.,
April 29, 2005;
280(17):
17562 - 17571.
[Abstract][Full Text][PDF]
L McClure, A E O'Connor, S Hayward, G Jenkin, D W Walker, and D J Phillips Effects of age and pregnancy on the circulatory activin response of sheep to acute inflammatory challenge by lipopolysaccharide
J. Endocrinol.,
April 1, 2005;
185(1):
139 - 149.
[Abstract][Full Text][PDF]
K. P McNatty, J. L Juengel, K. L Reader, S. Lun, S. Myllymaa, S. B Lawrence, A. Western, M. F Meerasahib, D. G Mottershead, N. P Groome, et al. Bone morphogenetic protein 15 and growth differentiation factor 9 co-operate to regulate granulosa cell function
Reproduction,
April 1, 2005;
129(4):
473 - 480.
[Abstract][Full Text][PDF]
B. D. Cherrington, T. A. Farmerie, C. A. Lents, J. D. Cantlon, M. S. Roberson, and C. M. Clay Activin Responsiveness of the Murine Gonadotropin-Releasing Hormone Receptor Gene Is Mediated by a Composite Enhancer Containing Spatially Distinct Regulatory Elements
Mol. Endocrinol.,
April 1, 2005;
19(4):
898 - 912.
[Abstract][Full Text][PDF]
K. P. Sarker, S. M. Wilson, and S. Bonni SnoN Is a Cell Type-specific Mediator of Transforming Growth Factor-{beta} Responses
J. Biol. Chem.,
April 1, 2005;
280(13):
13037 - 13046.
[Abstract][Full Text][PDF]
U. Valcourt, M. Kowanetz, H. Niimi, C.-H. Heldin, and A. Moustakas TGF-{beta} and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition
Mol. Biol. Cell,
April 1, 2005;
16(4):
1987 - 2002.
[Abstract][Full Text][PDF]
J.L. Juengel and K.P. McNatty The role of proteins of the transforming growth factor-{beta} superfamily in the intraovarian regulation of follicular development
Hum. Reprod. Update,
March 1, 2005;
11(2):
144 - 161.
[Abstract][Full Text][PDF]
D. S. Wilkinson, S. K. Ogden, S. A. Stratton, J. L. Piechan, T. T. Nguyen, G. A. Smulian, and M. C. Barton A Direct Intersection between p53 and Transforming Growth Factor {beta} Pathways Targets Chromatin Modification and Transcription Repression of the {alpha}-Fetoprotein Gene
Mol. Cell. Biol.,
February 1, 2005;
25(3):
1200 - 1212.
[Abstract][Full Text][PDF]
K. Bostrom, A. F. Zebboudj, Y. Yao, T. S. Lin, and A. Torres Matrix GLA Protein Stimulates VEGF Expression through Increased Transforming Growth Factor-{beta}1 Activity in Endothelial Cells
J. Biol. Chem.,
December 17, 2004;
279(51):
52904 - 52913.
[Abstract][Full Text][PDF]
E. del Re, Y. Sidis, D. A. Fabrizio, H. Y. Lin, and A. Schneyer Reconstitution and Analysis of Soluble Inhibin and Activin Receptor Complexes in a Cell-free System
J. Biol. Chem.,
December 17, 2004;
279(51):
53126 - 53135.
[Abstract][Full Text][PDF]
G. Xu, Y. Zhong, S. Munir, B. B. Yang, B. K. Tsang, and C. Peng Nodal Induces Apoptosis and Inhibits Proliferation in Human Epithelial Ovarian Cancer Cells via Activin Receptor-Like Kinase 7
J. Clin. Endocrinol. Metab.,
November 1, 2004;
89(11):
5523 - 5534.
[Abstract][Full Text][PDF]
L. Wine-Lee, K. J. Ahn, R. D. Richardson, Y. Mishina, K. M. Lyons, and E. B. Crenshaw III Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord
Development,
November 1, 2004;
131(21):
5393 - 5403.
[Abstract][Full Text][PDF]
K P McNatty, L G Moore, N L Hudson, L D Quirke, S B Lawrence, K Reader, J P Hanrahan, P Smith, N P Groome, M Laitinen, et al. The oocyte and its role in regulating ovulation rate: a new paradigm in reproductive biology
Reproduction,
October 1, 2004;
128(4):
379 - 386.
[Abstract][Full Text][PDF]
K. Bein, E. T. Odell-Fiddler, and M. Drinane Role of TGF-{beta}1 and JNK signaling in capillary tube patterning
Am J Physiol Cell Physiol,
October 1, 2004;
287(4):
C1012 - C1022.
[Abstract][Full Text][PDF]
R. M. Monteiro, S. M. C. de Sousa Lopes, O. Korchynskyi, P. t. Dijke, and C. L. Mummery Spatio-temporal activation of Smad1 and Smad5 in vivo: monitoring transcriptional activity of Smad proteins
J. Cell Sci.,
September 15, 2004;
117(20):
4653 - 4663.
[Abstract][Full Text][PDF]
D. Tomic, K. P. Miller, H. A. Kenny, T. K. Woodruff, P. Hoyer, and J. A. Flaws Ovarian Follicle Development Requires Smad3
Mol. Endocrinol.,
September 1, 2004;
18(9):
2224 - 2240.
[Abstract][Full Text][PDF]
I. Yakymovych, C.-H. Heldin, and S. Souchelnytskyi Smad2 Phosphorylation by Type I Receptor: CONTRIBUTION OF ARGININE 462 AND CYSTEINE 463 IN THE C TERMINUS OF SMAD2 FOR SPECIFICITY
J. Biol. Chem.,
August 20, 2004;
279(34):
35781 - 35787.
[Abstract][Full Text][PDF]
T. M. Doherty, L. A. Fitzpatrick, D. Inoue, J.-H. Qiao, M. C. Fishbein, R. C. Detrano, P. K. Shah, and T. B. Rajavashisth Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification
Endocr. Rev.,
August 1, 2004;
25(4):
629 - 672.
[Abstract][Full Text][PDF]
S. A. Pangas, C. J. Jorgez, and M. M. Matzuk Growth Differentiation Factor 9 Regulates Expression of the Bone Morphogenetic Protein Antagonist Gremlin
J. Biol. Chem.,
July 30, 2004;
279(31):
32281 - 32286.
[Abstract][Full Text][PDF]
S. Munir, G. Xu, Y. Wu, B. Yang, P. K. Lala, and C. Peng Nodal and ALK7 Inhibit Proliferation and Induce Apoptosis in Human Trophoblast Cells
J. Biol. Chem.,
July 23, 2004;
279(30):
31277 - 31286.
[Abstract][Full Text][PDF]
