Molecular Basis of Combined Pituitary Hormone Deficiencies
Laurie E. Cohen and
Sally Radovick
Division of Endocrinology (L.E.C.), Children’s Hospital and Harvard Medical School, Boston, Massachusetts 02115; and Division of Pediatric Endocrinology (S.R.), University of Chicago, Chicago, Illinois 60637
Correspondence: Address all correspondence and requests for reprints to: Sally Radovick, M.D., Department of Pediatrics, University of Chicago, 5841 South Maryland Avenue, MC5053, Chicago, Illinois 60637. E-mail: sradovic{at}peds.bsd.uchicago.edu
Pituitary gland commitment from oral ectoderm occurs in responseto inductive signals from the neuroepithelium of the ventraldiencephalon. Invagination of the oral ectoderm leads to thecreation of Rathke’s pouch. Intensified cell proliferationwithin Rathke’s pouch results in formation of the anteriorpituitary lobe. Subsequently, highly differentiated cell typesarise sequentially due to overlapping, but distinct, spatialand temporal patterns of signaling molecules and transcriptionfactors. Mutations in some of the pituitary-specific transcriptionfactors have been identified in patients with hypopituitarism,confirming the role of these factors in pituitary development.
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