Chandra P. Leo,
Sheau Yu Hsu and
Aaron J. W. Hsueh
Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305-5317
Correspondence: Address all correspondence and requests for reprints to: Aaron J. W. Hseuh, Ph.D., Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University Medical Center, 300 Pasteur Drive, Room A344, Stanford, California 94305-5317. E-mail: aaron. hsueh@forsythe.stanford.edu
The availability of the human genomic sequence is changing theway in which biological questions are addressed. Based on theprediction of genes from nucleotide sequences, homologies amongtheir encoded amino acids can be analyzed and used to placethem in distinct families. This serves as a first step in buildinghypotheses for testing the structural and functional propertiesof previously uncharacterized paralogous genes. As genomic informationfrom more organisms becomes available, these hypotheses canbe refined through comparative genomics and phylogenetic studies.Instead of the traditional single-gene approach in endocrineresearch, we are beginning to gain an understanding of entiremammalian genomes, thus providing the basis to reveal subfamiliesand pathways for genes involved in ligand signaling. The presentreview provides selective examples of postgenomic approachesin the analysis of novel genes involved in hormonal signalingand their chromosomal locations, polymorphisms, splicing variants,differential expression, and physiological function. In thepostgenomic era, scientists will be able to move from a gene-by-geneapproach to a reconstructionistic one by reading the encyclopediaof life from a global perspective. Eventually, a community-basedapproach will yield new insights into the complexity of intercellularcommunications, thereby offering us an understanding of hormonalphysiology and pathophysiology.
This article has been cited by other articles:
S. Mazerbourg and A. J.W. Hsueh Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands
Hum. Reprod. Update,
July 1, 2006;
12(4):
373 - 383.
[Abstract][Full Text][PDF]
A J W Hsueh, P Bouchard, and I Ben-Shlomo Hormonology: a genomic perspective on hormonal research
J. Endocrinol.,
December 1, 2005;
187(3):
333 - 338.
[Abstract][Full Text][PDF]
W. Wu, H. Kamma, M. Fujiwara, Y. Yano, H. Satoh, H. Hara, T. Yashiro, E. Ueno, and Y. Aiyoshi Altered Expression Patterns of Heterogeneous Nuclear Ribonucleoproteins A2 and B1 in the Adrenal Cortex
J. Histochem. Cytochem.,
April 1, 2005;
53(4):
487 - 495.
[Abstract][Full Text][PDF]
U. Vitt, D. Gietzen, K. Stevens, J. Wingrove, S. Becha, S. Bulloch, J. Burrill, N. Chawla, J. Chien, M. Crawford, et al. Identification of Candidate Disease Genes by EST Alignments, Synteny, and Expression and Verification of Ensembl Genes on Rat Chromosome 1q43-54
Genome Res.,
April 1, 2004;
14(4):
640 - 650.
[Abstract][Full Text][PDF]
K. De Bosscher, W. Vanden Berghe, and G. Haegeman The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression
Endocr. Rev.,
August 1, 2003;
24(4):
488 - 522.
[Abstract][Full Text][PDF]
I. Ben-Shlomo, S. Yu Hsu, R. Rauch, H. W. Kowalski, and A. J. W. Hsueh Signaling Receptome: A Genomic and Evolutionary Perspective of Plasma Membrane Receptors Involved in Signal Transduction
Sci. Signal.,
June 17, 2003;
2003(187):
re9 - re9.
[Abstract][Full Text][PDF]
D. O. Wiemers, L.-j. Shao, R. Ain, G. Dai, and M. J. Soares The Mouse Prolactin Gene Family Locus
Endocrinology,
January 1, 2003;
144(1):
313 - 325.
[Abstract][Full Text][PDF]
