The Lutropin/Choriogonadotropin Receptor, A 2002 Perspective
Mario Ascoli,
Francesca Fanelli and
Deborah L. Segaloff
Departments of Pharmacology (M.A.) and Physiology and Biophysics (D.L.S.), The University of Iowa, Iowa City, Iowa 52242-1109; and Dipartimento di Chimica (F.F.), Universitá di Modena e Reggio Emilia, Via Campi 183 41100 Modena, Italy
Correspondence: Address all correspondence and requests for reprints to: Dr. Mario Ascoli, Department of Pharmacology, The University of Iowa, 2-319B BSB, 51 Newton Road, Iowa City, Iowa 52242-1109. E-mail: mario-ascoli{at}uiowa.edu
Reproduction cannot take place without the proper functioningof the lutropin/choriogonadotropin receptor (LHR). When theLHR does not work properly, ovulation does not occur in femalesand Leydig cells do not develop normally in the male. Also,because the LHR is essential for sustaining the elevated levelsof progesterone needed to maintain pregnancy during the firsttrimester, disruptions in the functions of the LHR during pregnancyhave catastrophic consequences. As such, a full understandingof the biology of the LHR is essential to the survival of ourspecies. In this review we summarize our current knowledge ofthe structure, functions, and regulation of this important receptor.
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[Abstract][Full Text][PDF]
H.-F. Kwok, W.-K. So, Y. Wang, and W. Ge Zebrafish Gonadotropins and Their Receptors: I. Cloning and Characterization of Zebrafish Follicle-Stimulating Hormone and Luteinizing Hormone Receptors-- Evidence for Their Distinct Functions in Follicle Development
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C. Galet and M. Ascoli The Differential Binding Affinities of the Luteinizing Hormone (LH)/Choriogonadotropin Receptor for LH and Choriogonadotropin Are Dictated by Different Extracellular Domain Residues
Mol. Endocrinol.,
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H. Zhou, Y. Jiang, W. K W Ko, W. Li, and A. O L Wong Paracrine regulation of growth hormone gene expression by gonadotrophin release in grass carp pituitary cells: functional implications, molecular mechanisms and signal transduction
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T. P Meehan, B. G Harmon, M. E Overcast, K. K Yu, S. A Camper, D. Puett, and P. Narayan Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complex
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G. Piaditis, A. Angellou, G. Kontogeorgos, N. Mazarakis, T. Kounadi, G. Kaltsas, K. Vamvakidis, R. V. Lloyd, E. Horvath, and K. Kovacs Ectopic Bioactive Luteinizing Hormone Secretion by a Pancreatic Endocrine Tumor, Manifested as Luteinized Granulosa-Thecal Cell Tumor of the Ovaries
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U. M. Munshi, C. L. Clouser, H. Peegel, and K. M. J. Menon Evidence that Palmitoylation of Carboxyl Terminus Cysteine Residues of the Human Luteinizing Hormone Receptor Regulates Postendocytic Processing
Mol. Endocrinol.,
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B. Li, N. M. Nowak, S.-K. Kim, K. A. Jacobson, A. Bagheri, C. Schmidt, and J. Wess Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast: IDENTIFICATION OF SECOND-SITE MUTATIONS THAT RESTORE FUNCTION TO A COUPLING-DEFICIENT MUTANT M3 RECEPTOR
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L. Wang and K. M. J. Menon Regulation of Luteinizing Hormone/Chorionic Gonadotropin Receptor Messenger Ribonucleic Acid Expression in the Rat Ovary: Relationship to Cholesterol Metabolism
Endocrinology,
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M. Saint-Dizier, F. Foulon-Gauze, F. Lecompte, Y. Combarnous, and M. Chopineau Cloning and functional expression of the equine luteinizing hormone/chorionic gonadotrophin receptor
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S. Costagliola, M. Bonomi, N. G. Morgenthaler, J. Van Durme, V. Panneels, S. Refetoff, and G. Vassart Delineation of the Discontinuous-Conformational Epitope of a Monoclonal Antibody Displaying Full in Vitro and in Vivo Thyrotropin Activity
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E C Chin, T E Harris, and D R E Abayasekara Changes in cAMP-dependent protein kinase (PKA) and progesterone secretion in luteinizing human granulosa cells
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S Ramaswamy, C R Pohl, G R Marshall, and T M Plant A switch from continuous to episodic testicular testosterone release in response to pulsatile LH stimulation in juvenile rhesus monkeys (Macaca mulatta)
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N. A. Rahman, S. Kiiveri, A. Rivero-Muller, J. Levallet, S. Vierre, J. Kero, D. B. Wilson, M. Heikinheimo, and I. Huhtaniemi Adrenocortical Tumorigenesis in Transgenic Mice Expressing the Inhibin {alpha}-Subunit Promoter/Simian Virus 40 T-Antigen Transgene: Relationship between Ectopic Expression of Luteinizing Hormone Receptor and Transcription Factor GATA-4
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S. Mazerbourg, D. M. Bouley, S. Sudo, C. A. Klein, J. V. Zhang, K. Kawamura, L. V. Goodrich, H. Rayburn, M. Tessier-Lavigne, and A. J. W. Hsueh Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor 4 Null Mice Exhibit Intrauterine Growth Retardation Associated with Embryonic and Perinatal Lethality
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L. Montanelli, J. J. J. Van Durme, G. Smits, M. Bonomi, P. Rodien, E. J. Devor, K. Moffat-Wilson, L. Pardo, G. Vassart, and S. Costagliola Modulation of Ligand Selectivity Associated with Activation of the Transmembrane Region of the Human Follitropin Receptor
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M. Madhra, E. Gay, H. M. Fraser, and W.C. Duncan Alternative splicing of the human luteal LH receptor during luteolysis and maternal recognition of pregnancy
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D. Mizrachi and D. L. Segaloff Intracellularly Located Misfolded Glycoprotein Hormone Receptors Associate with Different Chaperone Proteins than Their Cognate Wild-Type Receptors
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F. Fanelli, M. Verhoef-Post, M. Timmerman, A. Zeilemaker, J. W. M. Martens, and A. P. N. Themmen Insight into Mutation-Induced Activation of the Luteinizing Hormone Receptor: Molecular Simulations Predict the Functional Behavior of Engineered Mutants at M398
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R. L. Bowen, G. Verdile, T. Liu, A. F. Parlow, G. Perry, M. A. Smith, R. N. Martins, and C. S. Atwood Luteinizing Hormone, a Reproductive Regulator That Modulates the Processing of Amyloid-{beta} Precursor Protein and Amyloid-{beta} Deposition
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J. D. Hennebold Characterization of the ovarian transcriptome through the use of differential analysis of gene expression methodologies
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A. K. Nair and K. M. J. Menon Isolation and Characterization of a Novel trans-Factor for Luteinizing Hormone Receptor mRNA from Ovary
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