The Functional Significance of FSH in Spermatogenesis and the Control of Its Secretion in Male Primates
Tony M. Plant and
Gary R. Marshall
Departments of Cell Biology and Physiology (T.M.P.) and Medicine
(G.R.M.), University of Pittsburgh School of Medicine, Pittsburgh,
Pennsylvania 15261
Correspondence: Address all correspondence and requests for reprints to: Tony M. Plant, Ph.D., Department of Cell Biology and Physiology, University of Pittsburgh, S-828A Scaife Hall, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261. E-mail: plant1+{at}pitt.edu
The aim of this review is to provide an integrative analysisof the
role of FSH in the control of testicular function inhigher primates,
including man. Attention is focused on theaction of FSH during
neonatal development, puberty, and adulthood.Whether FSH is the major
determinant of the adult complementof Sertoli cells and whether FSH is
obligatory for the initiation,maintenance, and restoration of
spermatogenesis is evaluated.The mechanism whereby the circulating
concentration of FSH regulatesspermatogonial proliferation to dictate
the sperm productionrate under physiological conditions in the adult
is discussedin detail. Inhibin B is the major component of the
testicularnegative feedback signal governing FSHß gene expression
andFSH secretion, and the evidence for this view is presented.The
review concludes with the presentation of a model for theoperation of
the FSH-inhibin B feedback control system regulatingsperm production
postpubertally in monkey and man, and withspeculation on issues of
clinical interest.
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