Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment
Fouad R. Kandeel,
Vivien K. T. Koussa and
Ronald S. Swerdloff
The Leslie and Susan Gonda (Goldschmied) Diabetes and Genetic
Research Center, Department of Diabetes, Endocrinology & Metabolism,
City of Hope National Medical Center, Duarte, California 91010; and
Department of Medicine, Harbor-UCLA Medical Center, Torrance,
California 90502
This review is designed to help the reproductive endocrinologist
integratehis or her professional activity with those of other
disciplinesincluding urology, radiology, neurology, and psychology in
orderto successfully manage all of the inseparable aspects of male
sexualand reproductive functioning. Significant advances in the field
ofmale sexual physiology and pathophysiology and new methods of
investigationand treatment of male sexual disorders are outlined. The
reviewsynthesizes available data on the following: norms of sexual
organs,aging and sexuality, role of central and peripheral
neurochemicalsin each stage of the sexual cycle, role of corporeal
smoothmuscles in the hemodynamic control of erection and detumescence,
influenceof psychological factors, drugs, and disease on all aspects
ofsexual functioning, and use of nocturnal penile tumescence
monitoring,imaging investigations, and neurophysiologic studies in the
diagnosticworkup of males with sexual dysfunction. Clinical algorithms
arepresented where appropriate. Extensive discussions on newly
developedstrategies in psychological and behavioral counseling, drug
therapy,tissue engineering, nonsurgical devices, and surgical
treatmentsfor all forms of sexual disorders are also provided. Lastly,
theeffect of sexual dysfunction and its treatment on quality oflife
in affected men is addressed, along with recommendationsfor future
research endeavors.
This article has been cited by other articles:
R. Yang, J. Wang, Y. Chen, Z. Sun, R. Wang, and Y. Dai Effect of Caffeine on Erectile Function via Up-Regulating Cavernous Cyclic Guanosine Monophosphate in Diabetic Rats
J Androl,
September 1, 2008;
29(5):
586 - 591.
[Abstract][Full Text][PDF]
S. Lamas, C. J. Lowenstein, and T. Michel Nitric oxide signaling comes of age: 20 years and thriving
Cardiovasc Res,
July 15, 2007;
75(2):
207 - 209.
[Full Text][PDF]
S. M Setter, J. L Iltz, J. E Fincham, R K. Campbell, and D. E Baker Phosphodiesterase 5 Inhibitors for Erectile Dysfunction
Ann. Pharmacother.,
July 1, 2005;
39(7):
1286 - 1295.
[Abstract][Full Text][PDF]
L. Vignozzi, S. Filippi, M. Luconi, A. Morelli, R. Mancina, M. Marini, G. B. Vannelli, S. Granchi, C. Orlando, S. Gelmini, et al. Oxytocin Receptor Is Expressed in the Penis and Mediates an Estrogen-Dependent Smooth Muscle Contractility
Endocrinology,
April 1, 2004;
145(4):
1823 - 1834.
[Abstract][Full Text][PDF]
S. Jesmin, C. N. Mowa, N. Matsuda, A.-E. Salah-Eldin, H. Togashi, I. Sakuma, Y. Hattori, and A. Kitabatake Evidence for a Potential Role of Estrogen in the Penis: Detection of Estrogen Receptor-{alpha} and -{beta} Messenger Ribonucleic Acid and Protein
Endocrinology,
December 1, 2002;
143(12):
4764 - 4774.
[Abstract][Full Text][PDF]
