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Endocrine Reviews 22 (2): 255-288
Copyright © 2001 by The Endocrine Society

Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology1

Nelly Auersperg, Alice S. T. Wong, Kyung-Chul Choi, Sung Keun Kang and Peter C. K. Leung

Department of Obstetrics and Gynaecology, British Columbia Women’s Hospital, University of British Columbia, Vancouver, British Columbia, V6H 3V5, Canada

The epithelial ovarian carcinomas, which make up more than 85% of human ovarian cancer, arise in the ovarian surface epithelium (OSE). The etiology and early events in the progression of these carcinomas are among the least understood of all major human malignancies because there are no appropriate animal models, and because methods to culture OSE have become available only recently. The objective of this article is to review the cellular and molecular mechanisms that underlie the control of normal and neoplastic OSE cell growth, differentiation, and expression of indicators of neoplastic progression. We begin with a brief discussion of the development of OSE, from embryonic to the adult. The pathological and genetic changes of OSE during neoplastic progression are next summarized. The histological characteristics of OSE cells in culture are also described. Finally, the potential involvement of hormones, growth factors, and cytokines is discussed in terms of their contribution to our understanding of the physiology of normal OSE and ovarian cancer development.




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 Mol Hum ReprodHome page
Y. Nagayoshi, T. Ohba, H. Yamamoto, Y. Miyahara, H. Tashiro, H. Katabuchi, and H. Okamura
Characterization of 17{beta}-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells
Mol. Hum. Reprod., September 1, 2005; 11(9): 615 - 621.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
E. Ntougkos, R. Rush, D. Scott, T. Frankenberg, H. Gabra, J. F. Smyth, and G. C. Sellar
The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates
Clin. Cancer Res., August 15, 2005; 11(16): 5764 - 5768.
[Abstract] [Full Text] [PDF]

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 Endocr Relat CancerHome page
J.-H. Choi, K.-C. Choi, N. Auersperg, and P. C K Leung
Gonadotropins upregulate the epidermal growth factor receptor through activation of mitogen-activated protein kinases and phosphatidyl-inositol-3-kinase in human ovarian surface epithelial cells
Endocr. Relat. Cancer, June 1, 2005; 12(2): 407 - 421.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
T. Daikoku, D. Wang, S. Tranguch, J. D. Morrow, S. Orsulic, R. N. DuBois, and S. K. Dey
Cyclooxygenase-1 Is a Potential Target for Prevention and Treatment of Ovarian Epithelial Cancer
Cancer Res., May 1, 2005; 65(9): 3735 - 3744.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
S. A. Bapat, A. M. Mali, C. B. Koppikar, and N. K. Kurrey
Stem and Progenitor-Like Cells Contribute to the Aggressive Behavior of Human Epithelial Ovarian Cancer
Cancer Res., April 15, 2005; 65(8): 3025 - 3029.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
Y. L. Pon, N. Auersperg, and A. S. T. Wong
Gonadotropins Regulate N-cadherin-mediated Human Ovarian Surface Epithelial Cell Survival at Both Post-translational and Transcriptional Levels through a Cyclic AMP/Protein Kinase A Pathway
J. Biol. Chem., April 15, 2005; 280(15): 15438 - 15448.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. Y. W. Bourguignon, E. Gilad, K. Rothman, and K. Peyrollier
Hyaluronan-CD44 Interaction with IQGAP1 Promotes Cdc42 and ERK Signaling, Leading to Actin Binding, Elk-1/Estrogen Receptor Transcriptional Activation, and Ovarian Cancer Progression
J. Biol. Chem., March 25, 2005; 280(12): 11961 - 11972.
[Abstract] [Full Text] [PDF]

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 ReproductionHome page
M Gaytan, M A Sanchez, C Morales, C Bellido, Y Millan, J Martin de las Mulas, J E Sanchez-Criado, and F Gaytan
Cyclic changes of the ovarian surface epithelium in the rat
Reproduction, March 1, 2005; 129(3): 311 - 321.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
F. Gaytan, C. Morales, M. L. Barreiro, P. Jeffery, L. K. Chopin, A. C. Herington, F. F. Casanueva, E. Aguilar, C. Dieguez, and M. Tena-Sempere
Expression of Growth Hormone Secretagogue Receptor Type 1a, the Functional Ghrelin Receptor, in Human Ovarian Surface Epithelium, Mullerian Duct Derivatives, and Ovarian Tumors
J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1798 - 1804.
[Abstract] [Full Text] [PDF]

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 Mol. Cell. ProteomicsHome page
D. M. Smith-Beckerman, K. W. Fung, K. E. Williams, N. Auersperg, A. K. Godwin, and A. L. Burlingame
Proteome Changes in Ovarian Epithelial Cells Derived from Women with BRCA1 Mutations and Family Histories of Cancer
Mol. Cell. Proteomics, February 1, 2005; 4(2): 156 - 168.
[Abstract] [Full Text] [PDF]

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 Toxicol SciHome page
D. A. Symonds, D. Tomic, K. P. Miller, and J. A. Flaws
Methoxychlor Induces Proliferation of the Mouse Ovarian Surface Epithelium
Toxicol. Sci., February 1, 2005; 83(2): 355 - 362.
[Abstract] [Full Text] [PDF]

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 Cancer Epidemiol. Biomarkers Prev.Home page
A. Lukanova and R. Kaaks
Endogenous Hormones and Ovarian Cancer: Epidemiology and Current Hypotheses
Cancer Epidemiol. Biomarkers Prev., January 1, 2005; 14(1): 98 - 107.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
S. L. Stewart, T. D. Querec, A. R. Ochman, B. N. Gruver, R. Bao, J. S. Babb, T. S. Wong, T. Koutroukides, A. D. Pinnola, A. Klein-Szanto, et al.
Characterization of a Carcinogenesis Rat Model of Ovarian Preneoplasia and Neoplasia
Cancer Res., November 15, 2004; 64(22): 8177 - 8183.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
J.-H. Choi, K.-C. Choi, N. Auersperg, and P. C. K. Leung
Overexpression of Follicle-Stimulating Hormone Receptor Activates Oncogenic Pathways in Preneoplastic Ovarian Surface Epithelial Cells
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5508 - 5516.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
G. Xu, Y. Zhong, S. Munir, B. B. Yang, B. K. Tsang, and C. Peng
Nodal Induces Apoptosis and Inhibits Proliferation in Human Epithelial Ovarian Cancer Cells via Activin Receptor-Like Kinase 7
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5523 - 5534.
[Abstract] [Full Text] [PDF]

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 ReproductionHome page
O Gubbay, W Guo, M T Rae, D Niven, A F Howie, A S McNeilly, L Xu, and S G Hillier
Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells
Reproduction, November 1, 2004; 128(5): 607 - 614.
[Abstract] [Full Text] [PDF]

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 J EndocrinolHome page
M T Rae, D Niven, A Ross, T Forster, R Lathe, H O D Critchley, P Ghazal, and S G Hillier
Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1{alpha} determined by microarray analysis
J. Endocrinol., October 1, 2004; 183(1): 19 - 28.
[Abstract] [Full Text] [PDF]

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 Mol. Endocrinol.Home page
R. Steinmetz, H. A. Wagoner, P. Zeng, J. R. Hammond, T. S. Hannon, J. L. Meyers, and O. H. Pescovitz
Mechanisms Regulating the Constitutive Activation of the Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Ovarian Cancer and the Effect of Ribonucleic Acid Interference for ERK1/2 on Cancer Cell Proliferation
Mol. Endocrinol., October 1, 2004; 18(10): 2570 - 2582.
[Abstract] [Full Text] [PDF]

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 J. Clin. Endocrinol. Metab.Home page
M. T. Rae, D. Niven, H. O. D. Critchley, C. R. Harlow, and S. G. Hillier
Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4538 - 4544.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
V. A. Heinzelmann-Schwarz, M. Gardiner-Garden, S. M. Henshall, J. Scurry, R. A. Scolyer, M. J. Davies, M. Heinzelmann, L. H. Kalish, A. Bali, J. G. Kench, et al.
Overexpression of the Cell Adhesion Molecules DDR1, Claudin 3, and Ep-CAM in Metaplastic Ovarian Epithelium and Ovarian Cancer
Clin. Cancer Res., July 1, 2004; 10(13): 4427 - 4436.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
Y. Zhu, J. Maric, M. Nilsson, M. Brannstrom, P.-O. Janson, and K. Sundfeldt
Formation and Barrier Function of Tight Junctions in Human Ovarian Surface Epithelium
Biol Reprod, July 1, 2004; 71(1): 53 - 59.
[Abstract] [Full Text] [PDF]

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 Reproductive SciencesHome page
C. M. Salamanca, S. L. Maines-Bandiera, P. C. K. Leung, Y.-L. Hu, and N. Auersperg
Effects of Epidermal Growth Factor/Hydrocortisone on the Growth and Differentiation of Human Ovarian Surface Epithelium
Reproductive Sciences, May 1, 2004; 11(4): 241 - 251.
[Abstract] [PDF]

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 CarcinogenesisHome page
G. Strathdee, B.R. Davies, J.K. Vass, N. Siddiqui, and R. Brown
Cell type-specific methylation of an intronic CpG island controls expression of the MCJ gene
Carcinogenesis, May 1, 2004; 25(5): 693 - 701.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
W.-L. Yang, A. K. Godwin, and X.-X. Xu
Tumor Necrosis Factor-{alpha}-Induced Matrix Proteolytic Enzyme Production and Basement Membrane Remodeling by Human Ovarian Surface Epithelial Cells: Molecular Basis Linking Ovulation and Cancer Risk
Cancer Res., February 15, 2004; 64(4): 1534 - 1540.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson
The Bone Morphogenetic Protein System In Mammalian Reproduction
Endocr. Rev., February 1, 2004; 25(1): 72 - 101.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
F. Spinella, L. Rosano, V. Di Castro, M. R. Nicotra, P. G. Natali, and A. Bagnato
Endothelin-1 Decreases Gap Junctional Intercellular Communication by Inducing Phosphorylation of Connexin 43 in Human Ovarian Carcinoma Cells
J. Biol. Chem., October 17, 2003; 278(42): 41294 - 41301.
[Abstract] [Full Text] [PDF]

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 Am J EpidemiolHome page
K.-H. Tung, M. T. Goodman, A. H. Wu, K. McDuffie, L. R. Wilkens, L. N. Kolonel, A. M. Y. Nomura, K. Y. Terada, M. E. Carney, and L. H. Sobin
Reproductive Factors and Epithelial Ovarian Cancer Risk by Histologic Type:A Multiethnic Case-Control Study
Am. J. Epidemiol., October 1, 2003; 158(7): 629 - 638.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
A. J. Li, R. L. Baldwin, and B. Y. Karlan
Short Androgen Receptor Allele Length Is a Poor Prognostic Factor in Epithelial Ovarian Carcinoma
Clin. Cancer Res., September 1, 2003; 9(10): 3667 - 3673.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
T. G. Shepherd and M. W. Nachtigal
Identification of a Putative Autocrine Bone Morphogenetic Protein-Signaling Pathway in Human Ovarian Surface Epithelium and Ovarian Cancer Cells
Endocrinology, August 1, 2003; 144(8): 3306 - 3314.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
D. C. Connolly, R. Bao, A. Y. Nikitin, K. C. Stephens, T. W. Poole, X. Hua, S. S. Harris, B. C. Vanderhyden, and T. C. Hamilton
Female Mice Chimeric for Expression of the Simian Virus 40 TAg under Control of the MISIIR Promoter Develop Epithelial Ovarian Cancer
Cancer Res., March 15, 2003; 63(6): 1389 - 1397.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
A. Tomassetti, F. Mangiarotti, M. Mazzi, S. Sforzini, S. Miotti, E. Galmozzi, P. C. Elwood, and S. Canevari
The Variant Hepatocyte Nuclear Factor 1 Activates the P1 Promoter of the Human {alpha}-Folate Receptor Gene in Ovarian Carcinoma
Cancer Res., February 1, 2003; 63(3): 696 - 704.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
L. Zhang, N. Yang, J.-R. Conejo-Garcia, D. Katsaros, A. Mohamed-Hadley, S. Fracchioli, K. Schlienger, A. Toll, B. Levine, S. C. Rubin, et al.
Expression of Endocrine Gland-derived Vascular Endothelial Growth Factor in Ovarian Carcinoma
Clin. Cancer Res., January 1, 2003; 9(1): 264 - 272.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
K. R. Kalli, O. I. Falowo, L. K. Bale, M. A. Zschunke, P. C. Roche, and C. A. Conover
Functional Insulin Receptors on Human Epithelial Ovarian Carcinoma Cells: Implications for IGF-II Mitogenic Signaling
Endocrinology, September 1, 2002; 143(9): 3259 - 3267.
[Abstract] [Full Text] [PDF]


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