Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology1
Nelly Auersperg,
Alice S. T. Wong,
Kyung-Chul Choi,
Sung Keun Kang and
Peter C. K. Leung
Department of Obstetrics and Gynaecology, British Columbia Women’s
Hospital, University of British Columbia, Vancouver, British Columbia,
V6H 3V5, Canada
The epithelial ovarian carcinomas, which make up more than 85%of
human ovarian cancer, arise in the ovarian surface epithelium(OSE).
The etiology and early events in the progression of thesecarcinomas
are among the least understood of all major humanmalignancies because
there are no appropriate animal models,and because methods to culture
OSE have become available onlyrecently. The objective of this article
is to review the cellularand molecular mechanisms that underlie the
control of normaland neoplastic OSE cell growth, differentiation, and
expressionof indicators of neoplastic progression. We begin with a
briefdiscussion of the development of OSE, from embryonic to the
adult.The pathological and genetic changes of OSE during neoplastic
progressionare next summarized. The histological characteristics of
OSEcells in culture are also described. Finally, the potential
involvementof hormones, growth factors, and cytokines is discussed in
termsof their contribution to our understanding of the physiologyof
normal OSE and ovarian cancer development.
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F. Gaytan, C. Morales, M. L. Barreiro, P. Jeffery, L. K. Chopin, A. C. Herington, F. F. Casanueva, E. Aguilar, C. Dieguez, and M. Tena-Sempere Expression of Growth Hormone Secretagogue Receptor Type 1a, the Functional Ghrelin Receptor, in Human Ovarian Surface Epithelium, Mullerian Duct Derivatives, and Ovarian Tumors
J. Clin. Endocrinol. Metab.,
March 1, 2005;
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1798 - 1804.
[Abstract][Full Text][PDF]
D. M. Smith-Beckerman, K. W. Fung, K. E. Williams, N. Auersperg, A. K. Godwin, and A. L. Burlingame Proteome Changes in Ovarian Epithelial Cells Derived from Women with BRCA1 Mutations and Family Histories of Cancer
Mol. Cell. Proteomics,
February 1, 2005;
4(2):
156 - 168.
[Abstract][Full Text][PDF]
D. A. Symonds, D. Tomic, K. P. Miller, and J. A. Flaws Methoxychlor Induces Proliferation of the Mouse Ovarian Surface Epithelium
Toxicol. Sci.,
February 1, 2005;
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355 - 362.
[Abstract][Full Text][PDF]
A. Lukanova and R. Kaaks Endogenous Hormones and Ovarian Cancer: Epidemiology and Current Hypotheses
Cancer Epidemiol. Biomarkers Prev.,
January 1, 2005;
14(1):
98 - 107.
[Abstract][Full Text][PDF]
S. L. Stewart, T. D. Querec, A. R. Ochman, B. N. Gruver, R. Bao, J. S. Babb, T. S. Wong, T. Koutroukides, A. D. Pinnola, A. Klein-Szanto, et al. Characterization of a Carcinogenesis Rat Model of Ovarian Preneoplasia and Neoplasia
Cancer Res.,
November 15, 2004;
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[Abstract][Full Text][PDF]
J.-H. Choi, K.-C. Choi, N. Auersperg, and P. C. K. Leung Overexpression of Follicle-Stimulating Hormone Receptor Activates Oncogenic Pathways in Preneoplastic Ovarian Surface Epithelial Cells
J. Clin. Endocrinol. Metab.,
November 1, 2004;
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[Abstract][Full Text][PDF]
G. Xu, Y. Zhong, S. Munir, B. B. Yang, B. K. Tsang, and C. Peng Nodal Induces Apoptosis and Inhibits Proliferation in Human Epithelial Ovarian Cancer Cells via Activin Receptor-Like Kinase 7
J. Clin. Endocrinol. Metab.,
November 1, 2004;
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[Abstract][Full Text][PDF]
O Gubbay, W Guo, M T Rae, D Niven, A F Howie, A S McNeilly, L Xu, and S G Hillier Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells
Reproduction,
November 1, 2004;
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607 - 614.
[Abstract][Full Text][PDF]
M T Rae, D Niven, A Ross, T Forster, R Lathe, H O D Critchley, P Ghazal, and S G Hillier Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1{alpha} determined by microarray analysis
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October 1, 2004;
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[Abstract][Full Text][PDF]
R. Steinmetz, H. A. Wagoner, P. Zeng, J. R. Hammond, T. S. Hannon, J. L. Meyers, and O. H. Pescovitz Mechanisms Regulating the Constitutive Activation of the Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Ovarian Cancer and the Effect of Ribonucleic Acid Interference for ERK1/2 on Cancer Cell Proliferation
Mol. Endocrinol.,
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[Abstract][Full Text][PDF]
M. T. Rae, D. Niven, H. O. D. Critchley, C. R. Harlow, and S. G. Hillier Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells
J. Clin. Endocrinol. Metab.,
September 1, 2004;
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[Abstract][Full Text][PDF]
V. A. Heinzelmann-Schwarz, M. Gardiner-Garden, S. M. Henshall, J. Scurry, R. A. Scolyer, M. J. Davies, M. Heinzelmann, L. H. Kalish, A. Bali, J. G. Kench, et al. Overexpression of the Cell Adhesion Molecules DDR1, Claudin 3, and Ep-CAM in Metaplastic Ovarian Epithelium and Ovarian Cancer
Clin. Cancer Res.,
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[Abstract][Full Text][PDF]
Y. Zhu, J. Maric, M. Nilsson, M. Brannstrom, P.-O. Janson, and K. Sundfeldt Formation and Barrier Function of Tight Junctions in Human Ovarian Surface Epithelium
Biol Reprod,
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[Abstract][Full Text][PDF]
C. M. Salamanca, S. L. Maines-Bandiera, P. C. K. Leung, Y.-L. Hu, and N. Auersperg Effects of Epidermal Growth Factor/Hydrocortisone on the Growth and Differentiation of Human Ovarian Surface Epithelium
Reproductive Sciences,
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[Abstract][PDF]
G. Strathdee, B.R. Davies, J.K. Vass, N. Siddiqui, and R. Brown Cell type-specific methylation of an intronic CpG island controls expression of the MCJ gene
Carcinogenesis,
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W.-L. Yang, A. K. Godwin, and X.-X. Xu Tumor Necrosis Factor-{alpha}-Induced Matrix Proteolytic Enzyme Production and Basement Membrane Remodeling by Human Ovarian Surface Epithelial Cells: Molecular Basis Linking Ovulation and Cancer Risk
Cancer Res.,
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S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson The Bone Morphogenetic Protein System In Mammalian Reproduction
Endocr. Rev.,
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F. Spinella, L. Rosano, V. Di Castro, M. R. Nicotra, P. G. Natali, and A. Bagnato Endothelin-1 Decreases Gap Junctional Intercellular Communication by Inducing Phosphorylation of Connexin 43 in Human Ovarian Carcinoma Cells
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[Abstract][Full Text][PDF]
K.-H. Tung, M. T. Goodman, A. H. Wu, K. McDuffie, L. R. Wilkens, L. N. Kolonel, A. M. Y. Nomura, K. Y. Terada, M. E. Carney, and L. H. Sobin Reproductive Factors and Epithelial Ovarian Cancer Risk by Histologic Type:A Multiethnic Case-Control Study
Am. J. Epidemiol.,
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[Abstract][Full Text][PDF]
A. J. Li, R. L. Baldwin, and B. Y. Karlan Short Androgen Receptor Allele Length Is a Poor Prognostic Factor in Epithelial Ovarian Carcinoma
Clin. Cancer Res.,
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[Abstract][Full Text][PDF]
