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Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390
Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.
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A. Yogi, C. Mercure, J. Touyz, G. E. Callera, A. C.I. Montezano, A. B. Aranha, R. C. Tostes, T. Reudelhuber, and R. M. Touyz Renal Redox-Sensitive Signaling, but Not Blood Pressure, Is Attenuated by Nox1 Knockout in Angiotensin II-Dependent Chronic Hypertension Hypertension, February 1, 2008; 51(2): 500 - 506. [Abstract] [Full Text] [PDF]
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Y. Wang, M. Zhu, M. Ayalew, and J. A. Ruff Down-regulation of Pkc1-mediated Signaling by the Deubiquitinating Enzyme Ubp3 J. Biol. Chem., January 25, 2008; 283(4): 1954 - 1961. [Abstract] [Full Text] [PDF]
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D. J. Weiss, C. D. Souza, O. A. Evanson, M. Sanders, and M. Rutherford Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium J. Leukoc. Biol., January 1, 2008; 83(1): 48 - 55. [Abstract] [Full Text] [PDF]
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C. G. Ziegler, F. Sicard, P. Lattke, S. R. Bornstein, M. Ehrhart-Bornstein, and A. W. Krug Dehydroepiandrosterone Induces a Neuroendocrine Phenotype in Nerve Growth Factor-Stimulated Chromaffin Pheochromocytoma PC12 Cells Endocrinology, January 1, 2008; 149(1): 320 - 328. [Abstract] [Full Text] [PDF]
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 G. W. Pearson and T. Hunter Real-time imaging reveals that noninvasive mammary epithelial acini can contain motile cells J. Cell Biol., December 31, 2007; 179(7): 1555 - 1567. [Abstract] [Full Text] [PDF]
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J. Wang, J.-Y. Zhou, and G. S. Wu ERK-Dependent MKP-1 Mediated Cisplatin Resistance in Human Ovarian Cancer Cells Cancer Res., December 15, 2007; 67(24): 11933 - 11941. [Abstract] [Full Text] [PDF]
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H. Vaidyanathan, J. Opoku-Ansah, S. Pastorino, H. Renganathan, M. L. Matter, and J. W. Ramos ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15 PNAS, December 11, 2007; 104(50): 19837 - 19842. [Abstract] [Full Text] [PDF]
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M. Nakamura, B. Han, T. Nishishita, Y. Bai, and K. Kakudo Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers J. Mol. Endocrinol., December 1, 2007; 39(6): 375 - 384. [Abstract] [Full Text] [PDF]
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M.-Y. Han, H. Kosako, T. Watanabe, and S. Hattori Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Regulates Actin Organization and Cell Motility by Phosphorylating the Actin Cross-Linking Protein EPLIN Mol. Cell. Biol., December 1, 2007; 27(23): 8190 - 8204. [Abstract] [Full Text] [PDF]
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T. Vomastek, M. P. Iwanicki, H.-J. Schaeffer, A. Tarcsafalvi, J. T. Parsons, and M. J. Weber RACK1 Targets the Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway To Link Integrin Engagement with Focal Adhesion Disassembly and Cell Motility Mol. Cell. Biol., December 1, 2007; 27(23): 8296 - 8305. [Abstract] [Full Text] [PDF]
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W. O. Sampaio, C. Henrique de Castro, R. A.S. Santos, E. L. Schiffrin, and R. M. Touyz Angiotensin-(1-7) Counterregulates Angiotensin II Signaling in Human Endothelial Cells Hypertension, December 1, 2007; 50(6): 1093 - 1098. [Abstract] [Full Text] [PDF]
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D. Gu, W. A. Beltran, Z. Li, G. M. Acland, and G. D. Aguirre Clinical Light Exposure, Photoreceptor Degeneration, and AP-1 Activation: A Cell Death or Cell Survival Signal in the Rhodopsin Mutant Retina? Invest. Ophthalmol. Vis. Sci., November 1, 2007; 48(11): 4907 - 4918. [Abstract] [Full Text] [PDF]
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 H. J. Bootsma, M. Egmont-Petersen, and P. W. M. Hermans Analysis of the In Vitro Transcriptional Response of Human Pharyngeal Epithelial Cells to Adherent Streptococcus pneumoniae: Evidence for a Distinct Response to Encapsulated Strains Infect. Immun., November 1, 2007; 75(11): 5489 - 5499. [Abstract] [Full Text] [PDF]
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 J. Cheetham, D. A. Smith, A. da Silva Dantas, K. S. Doris, M. J. Patterson, C. R. Bruce, and J. Quinn A Single MAPKKK Regulates the Hog1 MAPK Pathway in the Pathogenic Fungus Candida albicans Mol. Biol. Cell, November 1, 2007; 18(11): 4603 - 4614. [Abstract] [Full Text] [PDF]
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E. Szatmari, K. B. Kalita, G. Kharebava, and M. Hetman Role of Kinase Suppressor of Ras-1 in Neuronal Survival Signaling by Extracellular Signal-Regulated Kinase 1/2 J. Neurosci., October 17, 2007; 27(42): 11389 - 11400. [Abstract] [Full Text] [PDF]
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S.-W. Kim, J. S. Hong, S.-H. Ryu, W.-C. Chung, J.-H. Yoon, and J. S. Koo Regulation of Mucin Gene Expression by CREB via a Nonclassical Retinoic Acid Signaling Pathway Mol. Cell. Biol., October 1, 2007; 27(19): 6933 - 6947. [Abstract] [Full Text] [PDF]
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C.-H. Teng, W.-N. Huang, and T.-C. Meng Several Dual Specificity Phosphatases Coordinate to Control the Magnitude and Duration of JNK Activation in Signaling Response to Oxidative Stress J. Biol. Chem., September 28, 2007; 282(39): 28395 - 28407. [Abstract] [Full Text] [PDF]
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M. M. McKay and D. K. Morrison Caspase-dependent Cleavage Disrupts the ERK Cascade Scaffolding Function of KSR1 J. Biol. Chem., September 7, 2007; 282(36): 26225 - 26234. [Abstract] [Full Text] [PDF]
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Y.-Y. Cho, K. Yao, H.-G. Kim, B. S. Kang, D. Zheng, A. M. Bode, and Z. Dong Ribosomal S6 Kinase 2 Is a Key Regulator in Tumor Promoter Induced Cell Transformation Cancer Res., September 1, 2007; 67(17): 8104 - 8112. [Abstract] [Full Text] [PDF]
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A. Yogi, G.E. Callera, A.C.I. Montezano, A.B. Aranha, R.C. Tostes, E.L. Schiffrin, and R.M. Touyz Endothelin-1, but not Ang II, Activates MAP Kinases Through c-Src-Independent Ras-Raf-Dependent Pathways in Vascular Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., September 1, 2007; 27(9): 1960 - 1967. [Abstract] [Full Text] [PDF]
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 R. A. Falin and C. U. Cotton Acute Downregulation of ENaC by EGF Involves the PY Motif and Putative ERK Phosphorylation Site J. Gen. Physiol., August 27, 2007; 130(3): 313 - 328. [Abstract] [Full Text] [PDF]
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 H. J. Kim, Y. Lee, E.-J. Chang, H.-M. Kim, S.-P. Hong, Z. H. Lee, J. Ryu, and H.-H. Kim Suppression of Osteoclastogenesis by N,N-Dimethyl-D-erythro-sphingosine: A Sphingosine Kinase Inhibition-Independent Action Mol. Pharmacol., August 1, 2007; 72(2): 418 - 428. [Abstract] [Full Text] [PDF]
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 R. Tan, X. Zhang, J. Yang, Y. Li, and Y. Liu Molecular Basis for the Cell Type Specific Induction of SnoN Expression by Hepatocyte Growth Factor J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2340 - 2349. [Abstract] [Full Text] [PDF]
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 M. Maekawa, T. Yamamoto, M. Kohno, M. Takeichi, and E. Nishida Requirement for ERK MAP kinase in mouse preimplantation development Development, August 1, 2007; 134(15): 2751 - 2759. [Abstract] [Full Text] [PDF]
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S. Chu, L. Li, H. Singh, and R. Bhatia BCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous Leukemia Cancer Res., July 15, 2007; 67(14): 7045 - 7053. [Abstract] [Full Text] [PDF]
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N. Geoghegan-Morphet, D. Burger, X. Lu, V. Sathish, T. Peng, S. M. Sims, and Q. Feng Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes Cardiovasc Res, July 15, 2007; 75(2): 408 - 416. [Abstract] [Full Text] [PDF]
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C. Gaitanaki, T. Kalpachidou, I.-K. S. Aggeli, P. Papazafiri, and I. Beis CoCl2 induces protective events via the p38-MAPK signalling pathway and ANP in the perfused amphibian heart J. Exp. Biol., July 1, 2007; 210(13): 2267 - 2277. [Abstract] [Full Text] [PDF]
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 J. J. Benschop, S. Mohammed, M. O'Flaherty, A. J. R. Heck, M. Slijper, and F. L. H. Menke Quantitative Phosphoproteomics of Early Elicitor Signaling in Arabidopsis Mol. Cell. Proteomics, July 1, 2007; 6(7): 1198 - 1214. [Abstract] [Full Text] [PDF]
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K. Shiraishi and M. Ascoli Lutropin/Choriogonadotropin Stimulate the Proliferation of Primary Cultures of Rat Leydig Cells through a Pathway that Involves Activation of the Extracellularly Regulated Kinase 1/2 Cascade Endocrinology, July 1, 2007; 148(7): 3214 - 3225. [Abstract] [Full Text] [PDF]
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G. Li, E. J. Barrett, M. O. Barrett, W. Cao, and Z. Liu Tumor Necrosis Factor-{alpha} Induces Insulin Resistance in Endothelial Cells via a p38 Mitogen-Activated Protein Kinase-Dependent Pathway Endocrinology, July 1, 2007; 148(7): 3356 - 3363. [Abstract] [Full Text] [PDF]
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 K. Nasu, M. Nishida, T. Ueda, A. Yuge, N. Takai, and H. Narahara Application of the nuclear factor-{kappa}B inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E16 - E23. [Abstract] [Full Text] [PDF]
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T. Yokoyama, K. Takano, A. Yoshida, F. Katada, P. Sun, T. Takenawa, T. Andoh, and T. Endo DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation J. Cell Biol., June 21, 2007; 177(5): 781 - 793. [Abstract] [Full Text] [PDF]
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J.-G. Ren, Z. Li, and D. B. Sacks IQGAP1 modulates activation of B-Raf PNAS, June 19, 2007; 104(25): 10465 - 10469. [Abstract] [Full Text] [PDF]
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T. D. Prickett and D. L. Brautigan Cytokine Activation of p38 Mitogen-Activated Protein Kinase and Apoptosis Is Opposed by alpha-4 Targeting of Protein Phosphatase 2A for Site-Specific Dephosphorylation of MEK3 Mol. Cell. Biol., June 15, 2007; 27(12): 4217 - 4227. [Abstract] [Full Text] [PDF]
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S. Keates, X. Han, C. P. Kelly, and A. C. Keates Macrophage-Inflammatory Protein-3{alpha} Mediates Epidermal Growth Factor Receptor Transactivation and ERK1/2 MAPK Signaling in Caco-2 Colonic Epithelial Cells via Metalloproteinase-Dependent Release of Amphiregulin J. Immunol., June 15, 2007; 178(12): 8013 - 8021. [Abstract] [Full Text] [PDF]
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