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Endocrine Reviews 22 (1): 53-74
Copyright © 2001 by The Endocrine Society

The Somatomedin Hypothesis: 2001

Derek Le Roith, Carolyn Bondy, Shoshana Yakar, Jun-Li Liu and Andrew Butler

Clinical Endocrinology Branch (D.L., S.Y. J.-L. L.), and the Developmental Endocrinology Branch (C.B.), National Institutes of Health, Bethesda, Maryland 20892; and the Vollum Institute (A.B.), Oregon Health Sciences University, Portland, Oregon 97201

Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery that IGF-I is produced by most, if not all, tissues, the role of autocrine/paracrine IGF-I vs. the circulating form has been hotly debated. Recent experiments using transgenic and gene-deletion technologies have attempted to answer these questions. In the liver-specific igf-1 gene-deleted mouse model, postnatal growth and development are normal despite the marked reduction in circulating IGF-I and IGF-binding protein levels; free IGF-I levels are normal. Thus, the normal postnatal growth and development in these animals may be due to normal free IGF-I levels (from as yet unidentified sources), although the role of autocrine/paracrine IGF-I has yet to be determined.




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