This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Andersen, B. Articles by Rosenfeld, M. G. Search for Related Content PubMed PubMed Citation Articles by Andersen, B. Articles by Rosenfeld, M. G.

POU Domain Factors in the Neuroendocrine System: Lessons from Developmental Biology Provide Insights into Human Disease¹

Division of Endocrinology and Metabolism (B.A.), and Howard Hughes Medical Institute (M.G.R.), Department of Medicine, University of California, San Diego, La Jolla, California 92093-0648

POU domain factors are transcriptional regulators characterized by a highly conserved DNA-binding domain referred to as the POU domain. The structure of the POU domain has been solved, facilitating the understanding of how these proteins bind to DNA and regulate transcription via complex protein-protein interactions. Several members of the POU domain family have been implicated in the control of development and function of the neuroendocrine system. Such roles have been most clearly established for Pit-1, which is required for formation of somatotropes, lactotropes, and thyrotropes in the anterior pituitary gland, and for Brn-2, which is critical for formation of magnocellular and parvocellular neurons in the paraventricular and supraoptic nuclei of the hypothalamus. While genetic evidence is lacking, molecular biology experiments have implicated several other POU factors in the regulation of gene expression in the hypothalamus and pituitary gland. Pit-1 mutations in humans cause combined pituitary hormone deficiency similar to that found in mice deleted for the Pit-1 gene, providing a striking example of how basic developmental biology studies have provided important insights into human disease.

This article has been cited by other articles:

				D. Kelberman, K. Rizzoti, R. Lovell-Badge, I. C. A. F. Robinson, and M. T. Dattani Genetic Regulation of Pituitary Gland Development in Human and Mouse Endocr. Rev., December 1, 2009; 30(7): 790 - 829. [Abstract] [Full Text] [PDF]

				K. S Alatzoglou, D. Kelberman, and M. T Dattani The role of SOX proteins in normal pituitary development J. Endocrinol., March 1, 2009; 200(3): 245 - 258. [Abstract] [Full Text] [PDF]

				M. Doucleff and G. M. Clore Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1 PNAS, September 16, 2008; 105(37): 13871 - 13876. [Abstract] [Full Text] [PDF]

				J. Davis, D. Davis, B. Norman, and J. Piatigorsky Gene Expression of the Mouse Corneal Crystallin Aldh3a1: Activation by Pax6, Oct1, and p300 Invest. Ophthalmol. Vis. Sci., May 1, 2008; 49(5): 1814 - 1826. [Abstract] [Full Text] [PDF]

				N. Ben-Jonathan, C. R. LaPensee, and E. W. LaPensee What Can We Learn from Rodents about Prolactin in Humans? Endocr. Rev., February 1, 2008; 29(1): 1 - 41. [Abstract] [Full Text] [PDF]

				D. Kelberman and M. T. Dattani Hypothalamic and pituitary development: novel insights into the aetiology Eur. J. Endocrinol., August 1, 2007; 157(suppl_1): S3 - S14. [Abstract] [Full Text] [PDF]

				X. Zhu, A. S. Gleiberman, and M. G. Rosenfeld Molecular Physiology of Pituitary Development: Signaling and Transcriptional Networks Physiol Rev, July 1, 2007; 87(3): 933 - 963. [Abstract] [Full Text] [PDF]

				D. L. Duval, M. D. Jonsen, S. E. Diamond, P. Murapa, A. Jean, and A. Gutierrez-Hartmann Differential Utilization of Transcription Activation Subdomains by Distinct Coactivators Regulates Pit-1 Basal and Ras Responsiveness Mol. Endocrinol., January 1, 2007; 21(1): 172 - 185. [Abstract] [Full Text] [PDF]

				I. Pellegrini, C. Roche, M.-H. Quentien, M. Ferrand, G. Gunz, S. Thirion, C. Bagnis, A. Enjalbert, and J.-L. Franc Involvement of the Pituitary-Specific Transcription Factor Pit-1 in Somatolactotrope Cell Growth and Death: An Approach Using Dominant-Negative Pit-1 Mutants Mol. Endocrinol., December 1, 2006; 20(12): 3212 - 3227. [Abstract] [Full Text] [PDF]

				B. S. Ellsworth, N. Egashira, J. L. Haller, D. L. Butts, J. Cocquet, C. M. Clay, R. Y. Osamura, and S. A. Camper FOXL2 in the Pituitary: Molecular, Genetic, and Developmental Analysis Mol. Endocrinol., November 1, 2006; 20(11): 2796 - 2805. [Abstract] [Full Text] [PDF]

				R. M Luque, M. D Gahete, R. J Valentine, and R. D Kineman Examination of the direct effects of metabolic factors on somatotrope function in a non-human primate model, Papio anubis. J. Mol. Endocrinol., August 1, 2006; 37(1): 25 - 38. [Abstract] [Full Text] [PDF]

				A. Mukherjee, W. D. J. Ryder, A. Jostel, and S. M. Shalet Prolactin Deficiency Is Independently Associated with Reduced Insulin-Like Growth Factor I Status in Severely Growth Hormone-Deficient Adults J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2520 - 2525. [Abstract] [Full Text] [PDF]

				K. van Erp, K. Dach, I. Koch, J. Heesemann, and R. Hoffmann Role of strain differences on host resistance and the transcriptional response of macrophages to infection with Yersinia enterocolitica Physiol Genomics, March 13, 2006; 25(1): 75 - 84. [Abstract] [Full Text] [PDF]

				H. Nogami, Y. Hiraoka, K. Ogasawara, S. Aiso, and S. Hisano The role of pit-1 in the regulation of the rat growth hormone-releasing hormone receptor gene transcription by glucocorticoids J. Mol. Endocrinol., December 1, 2005; 35(3): 477 - 488. [Abstract] [Full Text] [PDF]

				P. G. Gallagher, R. I. Liem, E. Wong, M. J. Weiss, and D. M. Bodine GATA-1 and Oct-1 Are Required for Expression of the Human {alpha}-Hemoglobin-stabilizing Protein Gene J. Biol. Chem., November 25, 2005; 280(47): 39016 - 39023. [Abstract] [Full Text] [PDF]

				J. P. G. Turton, R. Reynaud, A. Mehta, J. Torpiano, A. Saveanu, K. S. Woods, A. Tiulpakov, V. Zdravkovic, J. Hamilton, S. Attard-Montalto, et al. Novel Mutations within the POU1F1 Gene Associated with Variable Combined Pituitary Hormone Deficiency J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4762 - 4770. [Abstract] [Full Text] [PDF]

				V. Goffin, S. Bernichtein, P. Touraine, and P. A. Kelly Development and Potential Clinical Uses of Human Prolactin Receptor Antagonists Endocr. Rev., May 1, 2005; 26(3): 400 - 422. [Abstract] [Full Text] [PDF]

				R. Alazard, M. Blaud, S. Elbaz, C. Vossen, G. Icre, G. Joseph, L. Nieto, and M. Erard Identification of the 'NORE' (N-Oct-3 responsive element), a novel structural motif and composite element Nucleic Acids Res., March 14, 2005; 33(5): 1513 - 1523. [Abstract] [Full Text] [PDF]

				S. Tanaka, Y. Kamachi, A. Tanouchi, H. Hamada, N. Jing, and H. Kondoh Interplay of SOX and POU Factors in Regulation of the Nestin Gene in Neural Primordial Cells Mol. Cell. Biol., October 15, 2004; 24(20): 8834 - 8846. [Abstract] [Full Text] [PDF]

				W. Herzog, C. Sonntag, S. von der Hardt, H. H. Roehl, Z. M. Varga, and M. Hammerschmidt Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis Development, August 1, 2004; 131(15): 3681 - 3692. [Abstract] [Full Text] [PDF]

				L. M. Valor, M. Castillo, J. A. Ortiz, and M. Criado Transcriptional Regulation by Activation and Repression Elements Located at the 5'-Noncoding Region of the Human {alpha}9 Nicotinic Receptor Subunit Gene J. Biol. Chem., September 26, 2003; 278(39): 37249 - 37255. [Abstract] [Full Text] [PDF]

				A. Cabral, D. F. Fischer, W. P. Vermeij, and C. Backendorf Distinct Functional Interactions of Human Skn-1 Isoforms with Ese-1 during Keratinocyte Terminal Differentiation J. Biol. Chem., May 9, 2003; 278(20): 17792 - 17799. [Abstract] [Full Text] [PDF]

				M. Kishimoto, Y. Okimura, K. Yagita, G. Iguchi, M. Fumoto, K. Iida, H. Kaji, H. Okamura, and K. Chihara Novel Function of the Transactivation Domain of a Pituitary-specific Transcription Factor, Pit-1 J. Biol. Chem., November 15, 2002; 277(47): 45141 - 45148. [Abstract] [Full Text] [PDF]

				M.-H. Quentien, I. Manfroid, D. Moncet, G. Gunz, M. Muller, M. Grino, A. Enjalbert, and I. Pellegrini Pitx Factors Are Involved in Basal and Hormone-regulated Activity of the Human Prolactin Promoter J. Biol. Chem., November 8, 2002; 277(46): 44408 - 44416. [Abstract] [Full Text] [PDF]

				H. Nogami, Y. Hiraoka, M. Matsubara, E. Nonobe, T. Harigaya, M. Katayama, N. Hemmi, S. Kobayashi, K. Mogi, S. Aiso, et al. A Composite Hormone Response Element Regulates Transcription of the Rat GHRH Receptor Gene Endocrinology, April 1, 2002; 143(4): 1318 - 1326. [Abstract] [Full Text] [PDF]

				J. C. Cross, L. Anson-Cartwright, and I. C. Scott Transcription Factors Underlying the Development and Endocrine Functions of the Placenta Recent Prog. Horm. Res., January 1, 2002; 57(1): 221 - 234. [Abstract] [Full Text] [PDF]

				T. M. Sugihara, E. I. Kudryavtseva, V. Kumar, J. J. Horridge, and B. Andersen The POU Domain Factor Skin-1a Represses the Keratin 14 Promoter Independent of DNA Binding. A POSSIBLE ROLE FOR INTERACTIONS BETWEEN Skn-1a AND CREB-BINDING PROTEIN/p300 J. Biol. Chem., August 24, 2001; 276(35): 33036 - 33044. [Abstract] [Full Text] [PDF]