help button home button Endocrine Society Endocrine Reviews
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints, Permissions and Rights
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamaguchi, A.
Right arrow Articles by Suda, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamaguchi, A.
Right arrow Articles by Suda, T.
Endocrine Reviews 21 (4): 393-411
Copyright © 2000 by The Endocrine Society

Regulation of Osteoblast Differentiation Mediated by Bone Morphogenetic Proteins, Hedgehogs, and Cbfa1

Akira Yamaguchi, Toshihisa Komori and Tatsuo Suda

Department of Oral Pathology (A.Y.), Nagasaki University School of Dentistry, 1–7-1 Sakamoto, Nagasaki 852, Department of Molecular Medicine (T.K.), School of Medicine, Osaka University, 2–2 Yamada-oka, Suita, Osaka 565 and "Form and Function", PRESTO, Japan Science and Technology Corporation, and Department of Biochemistry (T.S.), School of Dentistry, Showa University, 1–5-8 Hatanodai, Shinagawa-ku, Tokyo 142, Japan

Osteoblasts arise from common progenitors with chondrocytes, muscle and adipocytes, and various hormones and local factors regulate their differentiation. We review here regulation of osteoblast differentiation mediated by the local factors such as bone morphogenetic proteins (BMPs) and hedgehogs and the transcription factor, core-binding factor {alpha}-1 (Cbfa1). BMPs are the most potent regulators of osteoblast differentiation among the local factors. Sonic and Indian hedgehogs are involved in osteoblast differentiation by interacting with BMPs. Cbfa1, a member of the runt domain gene family, plays a major role in the processes of a determination of osteoblast cell lineage and maturation of osteoblasts. Cbfa1 is an essential transcription factor for osteoblast differentiation and bone formation, because Cbfa1-deficient mice completely lacked bone formation due to maturation arrest of osteoblasts. Although the regulatory mechanism of Cbfa1 expression has not been fully clarified, BMPs are an important local factor that up-regulates Cbfa1 expression. Thus, the intimate interaction between local factors such as BMPs and hedgehogs and the transcription factor, Cbfa1, is important to osteoblast differentiation and bone formation.




This article has been cited by other articles:


Home page
 IBMS BoneKEyHome page
R. Nishimura
A Novel Role for TGF-{beta}1 in Bone Remodeling
IBMS BoneKEy, November 1, 2009; 6(11): 434 - 438.
[Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S.-F. Chang, T.-K. Chang, H.-H. Peng, Y.-T. Yeh, D.-Y. Lee, C.-R. Yeh, J. Zhou, C.-K. Cheng, C. A. Chang, and J.-J. Chiu
BMP-4 Induction of Arrest and Differentiation of Osteoblast-Like Cells via p21CIP1 and p27KIP1 Regulation
Mol. Endocrinol., November 1, 2009; 23(11): 1827 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Mao, T. Yang, Z. Gu, W. C. Heird, M. J. Finegold, B. Lee, and S. J. Wakil
aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues
PNAS, October 13, 2009; 106(41): 17576 - 17581.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. W. Park, H. Waki, W.-K. Kim, B. S. J. Davies, S. G. Young, F. Parhami, and P. Tontonoz
The Small Molecule Phenamil Induces Osteoblast Differentiation and Mineralization
Mol. Cell. Biol., July 15, 2009; 29(14): 3905 - 3914.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Endo, K. Ohta, and T. Kobayashi
Expression and Function of Cbfa-1/Runx2 in Thyroid Papillary Carcinoma Cells
J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2409 - 2412.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. Abzhanov, S. J. Rodda, A. P. McMahon, and C. J. Tabin
Regulation of skeletogenic differentiation in cranial dermal bone
Development, September 1, 2007; 134(17): 3133 - 3144.
[Abstract] [Full Text] [PDF]

Home page
 J Bone Joint Surg BrHome page
K. Watanabe, H. Tsuchiya, K. Sakurakichi, and K. Tomita
Bone transport using hydroxyapatite loaded with bone morphogenetic protein in rabbits
J Bone Joint Surg Br, August 1, 2007; 89-B(8): 1122 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Shimoyama, M. Wada, F. Ikeda, K. Hata, T. Matsubara, A. Nifuji, M. Noda, K. Amano, A. Yamaguchi, R. Nishimura, et al.
Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function
Mol. Biol. Cell, July 1, 2007; 18(7): 2411 - 2418.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Luan, X.-P. Yu, K. Xu, B. Ding, J. Yu, Y. Huang, N. Yang, P. Lengyel, P. E. Di Cesare, and C.-j. Liu
The Retinoblastoma Protein Is an Essential Mediator of Osteogenesis That Links the p204 Protein to the Cbfa1 Transcription Factor Thereby Increasing Its Activity
J. Biol. Chem., June 8, 2007; 282(23): 16860 - 16870.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Yamamoto, N. Udagawa, S. Matsuura, Y. Nakamichi, H. Horiuchi, A. Hosoya, M. Nakamura, H. Ozawa, K. Takaoka, J. M. Penninger, et al.
Osteoblasts Provide a Suitable Microenvironment for the Action of Receptor Activator of Nuclear Factor-{kappa}B Ligand
Endocrinology, July 1, 2006; 147(7): 3366 - 3374.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
D. Vernet, G. Nolazco, L. Cantini, T. R. Magee, A. Qian, J. Rajfer, and N. F. Gonzalez-Cadavid
Evidence That Osteogenic Progenitor Cells in the Human Tunica Albuginea May Originate from Stem Cells: Implications for Peyronie Disease
Biol Reprod, December 1, 2005; 73(6): 1199 - 1210.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Nakashima, T. Katagiri, and M. Tamura
Cross-talk between Wnt and Bone Morphogenetic Protein 2 (BMP-2) Signaling in Differentiation Pathway of C2C12 Myoblasts
J. Biol. Chem., November 11, 2005; 280(45): 37660 - 37668.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Oshima, M. Abe, J. Asano, T. Hara, K. Kitazoe, E. Sekimoto, Y. Tanaka, H. Shibata, T. Hashimoto, S. Ozaki, et al.
Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
Blood, November 1, 2005; 106(9): 3160 - 3165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
T. Morgan, G. J. Atkins, M. K. Trivett, S. A. Johnson, M. Kansara, S. L. Schlicht, J. L. Slavin, P. Simmons, I. Dickinson, G. Powell, et al.
Molecular Profiling of Giant Cell Tumor of Bone and the Osteoclastic Localization of Ligand for Receptor Activator of Nuclear Factor {kappa}B
Am. J. Pathol., July 1, 2005; 167(1): 117 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Br J OphthalmolHome page
S Toyran, A Y Lin, and D P Edward
Expression of growth differentiation factor-5 and bone morphogenic protein-7 in intraocular osseous metaplasia
Br J Ophthalmol, July 1, 2005; 89(7): 885 - 890.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
D.D. Bosshardt
Are Cementoblasts a Subpopulation of Osteoblasts or a Unique Phenotype?
Journal of Dental Research, May 1, 2005; 84(5): 390 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Hata, R. Nishimura, M. Ueda, F. Ikeda, T. Matsubara, F. Ichida, K. Hisada, T. Nokubi, A. Yamaguchi, and T. Yoneda
A CCAAT/Enhancer Binding Protein {beta} Isoform, Liver-Enriched Inhibitory Protein, Regulates Commitment of Osteoblasts and Adipocytes
Mol. Cell. Biol., March 1, 2005; 25(5): 1971 - 1979.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-j. Liu, E. Chang, J. Yu, C. S. Carlson, L. Prazak, X.-P. Yu, B. Ding, P. Lengyel, and P. E. D. Cesare
The Interferon-inducible p204 Protein Acts as a Transcriptional Coactivator of Cbfa1 and Enhances Osteoblast Differentiation
J. Biol. Chem., January 28, 2005; 280(4): 2788 - 2796.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. I. Reinhold, M. Abe, R. M. Kapadia, Z. Liao, and M. C. Naski
FGF18 Represses Noggin Expression and Is Induced by Calcineurin
J. Biol. Chem., September 10, 2004; 279(37): 38209 - 38219.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
L. Mejia-Luna and G. Avila
Ca2+ channel regulation by transforming growth factor-{beta}1 and bone morphogenetic protein-2 in developing mice myotubes
J. Physiol., August 15, 2004; 559(1): 41 - 54.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Ichida, R. Nishimura, K. Hata, T. Matsubara, F. Ikeda, K. Hisada, H. Yatani, X. Cao, T. Komori, A. Yamaguchi, et al.
Reciprocal Roles of Msx2 in Regulation of Osteoblast and Adipocyte Differentiation
J. Biol. Chem., August 6, 2004; 279(32): 34015 - 34022.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
T. M. Doherty, L. A. Fitzpatrick, D. Inoue, J.-H. Qiao, M. C. Fishbein, R. C. Detrano, P. K. Shah, and T. B. Rajavashisth
Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification
Endocr. Rev., August 1, 2004; 25(4): 629 - 672.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. L. Sierra, S.-L. Cheng, A. P. Loewy, N. Charlton-Kachigian, and D. A. Towler
MINT, the Msx2 Interacting Nuclear Matrix Target, Enhances Runx2-dependent Activation of the Osteocalcin Fibroblast Growth Factor Response Element
J. Biol. Chem., July 30, 2004; 279(31): 32913 - 32923.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
X.-D. CHEN, L. W. FISHER, P. G. ROBEY, and M. F. YOUNG
The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation
FASEB J, June 1, 2004; 18(9): 948 - 958.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Komaki, A. Asakura, M. A. Rudnicki, J. Sodek, and S. Cheifetz
MyoD enhances BMP7-induced osteogenic differentiation of myogenic cell cultures
J. Cell Sci., March 15, 2004; 117(8): 1457 - 1468.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Hay, J. Lemonnier, O. Fromigue, H. Guenou, and P. J. Marie
Bone Morphogenetic Protein Receptor IB Signaling Mediates Apoptosis Independently of Differentiation in Osteoblastic Cells
J. Biol. Chem., January 16, 2004; 279(3): 1650 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
T. Aberg, A. Cavender, J. S. Gaikwad, A. L.J.J. Bronckers, X. Wang, J. Waltimo-Siren, I. Thesleff, and R. N. D'Souza
Phenotypic Changes in Dentition of Runx2 Homozygote-null Mutant Mice
J. Histochem. Cytochem., January 1, 2004; 52(1): 131 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
J. Melrose, S. Smith, P. Ghosh, and J. Whitelock
Perlecan, the Multidomain Heparan Sulfate Proteoglycan of Basement Membranes, Is also a Prominent Component of the Cartilaginous Primordia in the Developing Human Fetal Spine
J. Histochem. Cytochem., October 1, 2003; 51(10): 1331 - 1341.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
H. Cheng, W. Jiang, F. M. Phillips, R. C. Haydon, Y. Peng, L. Zhou, H. H. Luu, N. An, B. Breyer, P. Vanichakarn, et al.
Osteogenic Activity of the Fourteen Types of Human Bone Morphogenetic Proteins (BMPs)
J. Bone Joint Surg. Am., August 1, 2003; 85(8): 1544 - 1552.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K.-i. Hirose, H. Tomiyama, R. Okazaki, T. Arai, Y. Koji, G. Zaydun, S. Hori, and A. Yamashina
Increased Pulse Wave Velocity Associated with Reduced Calcaneal Quantitative Osteo-sono Index: Possible Relationship Between Atherosclerosis and Osteopenia
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2573 - 2578.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Sowa, H. Kaji, L. Canaff, G. N. Hendy, T. Tsukamoto, T. Yamaguchi, K. Miyazono, T. Sugimoto, and K. Chihara
Inactivation of Menin, the Product of the Multiple Endocrine Neoplasia Type 1 Gene, Inhibits the Commitment of Multipotential Mesenchymal Stem Cells into the Osteoblast Lineage
J. Biol. Chem., May 30, 2003; 278(23): 21058 - 21069.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Qi, D. J. Aguiar, S. M. Williams, A. La Pean, W. Pan, and C. M. Verfaillie
Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells
PNAS, March 18, 2003; 100(6): 3305 - 3310.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Takeuchi, S. Watanabe, G. Ishii, S. Takeda, K. Nakayama, S. Fukumoto, Y. Kaneta, D. Inoue, T. Matsumoto, K. Harigaya, et al.
Interleukin-11 as a Stimulatory Factor for Bone Formation Prevents Bone Loss with Advancing Age in Mice
J. Biol. Chem., December 6, 2002; 277(50): 49011 - 49018.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. L. Hager-Theodorides, S. V. Outram, D. K. Shah, R. Sacedon, R. E. Shrimpton, A. Vicente, A. Varas, and T. Crompton
Bone Morphogenetic Protein 2/4 Signaling Regulates Early Thymocyte Differentiation
J. Immunol., November 15, 2002; 169(10): 5496 - 5504.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. M. Willis, A. P. Loewy, N. Charlton-Kachigian, J.-S. Shao, D. M. Ornitz, and D. A. Towler
Regulation of Osteocalcin Gene Expression by a Novel Ku Antigen Transcription Factor Complex
J. Biol. Chem., September 27, 2002; 277(40): 37280 - 37291.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Hadjiargyrou, F. Lombardo, S. Zhao, W. Ahrens, J. Joo, H. Ahn, M. Jurman, D. W. White, and C. T. Rubin
Transcriptional Profiling of Bone Regeneration. INSIGHT INTO THE MOLECULAR COMPLEXITY OF WOUND REPAIR
J. Biol. Chem., August 9, 2002; 277(33): 30177 - 30182.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. M. Ornitz and P. J. Marie
FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
Genes & Dev., June 15, 2002; 16(12): 1446 - 1465.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Okazaki, D. Inoue, M. Shibata, M. Saika, S. Kido, H. Ooka, H. Tomiyama, Y. Sakamoto, and T. Matsumoto
Estrogen Promotes Early Osteoblast Differentiation and Inhibits Adipocyte Differentiation in Mouse Bone Marrow Stromal Cell Lines that Express Estrogen Receptor (ER) {alpha} or {beta}
Endocrinology, June 1, 2002; 143(6): 2349 - 2356.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
W. Liu, S. Toyosawa, T. Furuichi, N. Kanatani, C. Yoshida, Y. Liu, M. Himeno, S. Narai, A. Yamaguchi, and T. Komori
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
J. Cell Biol., October 1, 2001; 155(1): 157 - 166.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Yang, K. Fizazi, S. Peleg, C. R. Sikes, A. K. Raymond, N. Jamal, M. Hu, M. Olive, L. A. Martinez, C. G. Wood, et al.
Prostate Cancer Cells Induce Osteoblast Differentiation through a Cbfa1-dependent Pathway
Cancer Res., July 1, 2001; 61(14): 5652 - 5659.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Gruber, C. Mayer, K. Bobacz, M.-T. Krauth, W. Graninger, F. P. Luyten, and L. Erlacher
Effects of Cartilage-Derived Morphogenetic Proteins and Osteogenic Protein-1 on Osteochondrogenic Differentiation of Periosteum-Derived Cells
Endocrinology, May 1, 2001; 142(5): 2087 - 2094.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 2000 by The Endocrine Society