Adrenomedullin, a Multifunctional Regulatory Peptide1
Joy Patricia Hinson,
Supriya Kapas and
David Michael Smith
Department of Molecular and Cellular Biology (J.P.H.) and Clinical
Sciences Research Centre (S.K.), St. Bartholomew’s and the Royal
London School of Medicine and Dentistry, Queen Mary and Westfield
College, University of London, London E1 4NS; and Department of
Metabolic Medicine (D.M.S.), Division of Investigative Sciences,
Imperial College School of Medicine, Hammersmith Hospital, London W12
0NN United Kingdom
Since the discovery of adrenomedullin in 1993 several hundredpapers
have been published regarding the regulation of its secretionand the
multiplicity of its actions. It has been shown to bean almost
ubiquitous peptide, with the number of tissues andcell types
synthesizing adrenomedullin far exceeding those thatdo not. In
Section II of this paper we give a comprehensivereview
both of tissues and cell lines secreting adrenomedullinand of the
mechanisms regulating gene expression. The data oncirculating
adrenomedullin, obtained with the various assaysavailable, are also
reviewed, and the disease states in whichplasma adrenomedullin is
elevated are listed. In Section IIIthe pharmacology and
biochemistry of adrenomedullin bindingsites, both specific sites and
calcitonin gene-related peptide(CGRP) receptors, are discussed. In
particular, the putativeadrenomedullin receptor clones and signal
transduction pathwaysare described. In Section IV the
various actions of adrenomedullinare discussed: its actions on
cellular growth, the cardiovascularsystem, the central nervous system,
and the endocrine systemare all considered. Finally, in Section
V, we consider someunresolved issues and propose future areas
for research.
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280(6):
F964 - F971.
[Abstract][Full Text][PDF]
D. Naot, K. E. Callon, A. Grey, G. J. S. Cooper, I. R. Reid, and J. Cornish A Potential Role for Adrenomedullin as a Local Regulator of Bone Growth
Endocrinology,
May 1, 2001;
142(5):
1849 - 1857.
[Abstract][Full Text]
T. Udono, K. Takahashi, M. Nakayama, A. Yoshinoya, K. Totsune, O. Murakami, Y. K. Durlu, M. Tamai, and S. Shibahara Induction of Adrenomedullin by Hypoxia in Cultured Retinal Pigment Epithelial Cells
Invest. Ophthalmol. Vis. Sci.,
April 1, 2001;
42(5):
1080 - 1086.
[Abstract][Full Text]
P. Rocchi, F. Boudouresque, A. J. Zamora, X. Muracciole, E. Lechevallier, P.-M. Martin, and L'H. Ouafik Expression of Adrenomedullin and Peptide Amidation Activity in Human Prostate Cancer and in Human Prostate Cancer Cell Lines
Cancer Res.,
February 1, 2001;
61(3):
1196 - 1206.
[Abstract][Full Text]
M. Fujioka, K. Nishio, T. Sakaki, N. Minamino, and K. Kitamura Adrenomedullin in Patients With Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Stroke,
December 1, 2000;
31
(12):
3079 - 3083.
[Full Text]
A. Ladoux and C. Frelin Coordinated Up-regulation by Hypoxia of Adrenomedullin and One of Its Putative Receptors (RDC-1) in Cells of the Rat Blood-Brain Barrier
J. Biol. Chem.,
December 15, 2000;
275(51):
39914 - 39919.
[Abstract][Full Text][PDF]
R. Pio, A. Martinez, E. J. Unsworth, J. A. Kowalak, J. A. Bengoechea, P. F. Zipfel, T. H. Elsasser, and F. Cuttitta Complement Factor H Is a Serum-binding Protein for Adrenomedullin, and the Resulting Complex Modulates the Bioactivities of Both Partners
J. Biol. Chem.,
April 6, 2001;
276(15):
12292 - 12300.
[Abstract][Full Text][PDF]
K. M. Caron and O. Smithies Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
PNAS,
January 16, 2001;
98(2):
615 - 619.
[Abstract][Full Text][PDF]
R. D. Reidelberger, L. Kelsey, and D. Heimann Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats
Am J Physiol Regulatory Integrative Comp Physiol,
May 1, 2002;
282(5):
R1395 - R1404.
[Abstract][Full Text][PDF]
