This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints, Permissions and Rights Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bray, G. A. Articles by Greenway, F. L. Search for Related Content PubMed PubMed Citation Articles by Bray, G. A. Articles by Greenway, F. L.

Current and Potential Drugs for Treatment of Obesity

Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808-4124

I. Introduction

II. Criteria for Evaluating the Efficacy of Antiobesity Treatment

III. Physiological and Pharmacological Mechanisms to Reduce Food Intake

A. Peripherally acting agents

B. Centrally acting agents

IV. Drugs That Alter Metabolism

A. Preabsorptive agents

B. Postabsorptive modifiers of nutrient metabolism

V. Drugs That Increase Energy Expenditure

A. Thyroid hormone

B. Adrenergic thermogenic drugs

VI. Conclusion

This article has been cited by other articles:

				B. A. Spear, S. E. Barlow, C. Ervin, D. S. Ludwig, B. E. Saelens, K. E. Schetzina, and E. M. Taveras Recommendations for Treatment of Child and Adolescent Overweight and Obesity Pediatrics, December 1, 2007; 120(Supplement_4): S254 - S288. [Abstract] [Full Text] [PDF]

				A. Guijarro, S. Suzuki, C. Chen, H. Kirchner, F. A. Middleton, S. Nadtochiy, P. S. Brookes, A. Niijima, A. Inui, and M. M. Meguid Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1474 - R1489. [Abstract] [Full Text] [PDF]

				J. Yin, J. Zhang, and J. D. Chen Inhibitory effects of intestinal electrical stimulation on food intake, weight loss and gastric emptying in rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R78 - R82. [Abstract] [Full Text] [PDF]

				G. A. Bray and F. L. Greenway Pharmacological Treatment of the Overweight Patient Pharmacol. Rev., June 1, 2007; 59(2): 151 - 184. [Full Text] [PDF]

				Y. Si, J. Yoon, and K. Lee Flux profile and modularity analysis of time-dependent metabolic changes of de novo adipocyte formation Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1637 - E1646. [Abstract] [Full Text] [PDF]

				D. C.W. Lau, J. D. Douketis, K. M. Morrison, I. M. Hramiak, A. M. Sharma, E. Ur, and for members of the Obesity Canada Clinical Practic 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary] Can. Med. Assoc. J., April 10, 2007; 176(8): S1 - S13. [Full Text] [PDF]

				D. C.W. Lau, J. D. Douketis, K. M. Morrison, I. M. Hramiak, A. M. Sharma, E. Ur, and pour les membres du Groupe d'experts d'Obesite Can Lignes directrices canadiennes de 2006 sur la prise en charge et la prevention de l'obesite chez les adultes et les enfants [sommaire] Can. Med. Assoc. J., April 10, 2007; 176(8): SF1 - SF14. [Full Text] [PDF]

				R. Christensen, E. M. Bartels, A. Astrup, and H. Bliddal Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis Ann Rheum Dis, April 1, 2007; 66(4): 433 - 439. [Abstract] [Full Text] [PDF]

				K. E. Foster-Schubert and D. E. Cummings Emerging Therapeutic Strategies for Obesity Endocr. Rev., December 1, 2006; 27(7): 779 - 793. [Abstract] [Full Text] [PDF]

				J J G Hillebrand, A C M Heinsbroek, M J H Kas, and R A H Adan The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia J. Mol. Endocrinol., February 1, 2006; 36(1): 153 - 162. [Abstract] [Full Text] [PDF]

				K. J. Miller SEROTONIN 5-HT2C RECEPTOR AGONISTS: POTENTIAL FOR THE TREATMENT OF OBESITY Mol. Interv., October 1, 2005; 5(5): 282 - 291. [Abstract] [Full Text] [PDF]

				J. T. Mallare, A. H. Karabell, P. Velasquez-Mieyer, S. R.S. Stender, and M. L. Christensen Current and Future Treatment of Metabolic Syndrome and Type 2 Diabetes in Children and Adolescents Diabetes Spectr, October 1, 2005; 18(4): 220 - 228. [Abstract] [Full Text] [PDF]

				The American Diabetes Association, the North American Association for the Study of Ob, and and the American Society for Clinical Nutrition Weight Management Using Lifestyle Modification in the Prevention and Management of Type 2 Diabetes: Rationale and Strategies Clin. Diabetes, July 1, 2005; 23(3): 130 - 136. [Full Text] [PDF]

				Z. Li, M. Maglione, W. Tu, W. Mojica, D. Arterburn, L. R. Shugarman, L. Hilton, M. Suttorp, V. Solomon, P. G. Shekelle, et al. Meta-Analysis: Pharmacologic Treatment of Obesity Ann Intern Med, April 5, 2005; 142(7): 532 - 546. [Abstract] [Full Text] [PDF]

				J. Klein, S. Westphal, D. Kraus, B. Meier, N. Perwitz, V. Ott, M. Fasshauer, and H H. Klein Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes J. Endocrinol., November 1, 2004; 183(2): 299 - 307. [Abstract] [Full Text] [PDF]

				S. Klein, N. F Sheard, X. Pi-Sunyer, A. Daly, J. Wylie-Rosett, K. Kulkarni, and N. G Clark Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies. A statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition Am. J. Clinical Nutrition, August 1, 2004; 80(2): 257 - 263. [Abstract] [Full Text] [PDF]

				S. Klein, N. F. Sheard, X. Pi-Sunyer, A. Daly, J. Wylie-Rosett, K. Kulkarni, and N. G. Clark Weight Management Through Lifestyle Modification for the Prevention and Management of Type 2 Diabetes: Rationale and Strategies: A statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition Diabetes Care, August 1, 2004; 27(8): 2067 - 2073. [Full Text] [PDF]

				S. L. Norris, X. Zhang, A. Avenell, E. Gregg, C. H. Schmid, C. Kim, and J. Lau Efficacy of Pharmacotherapy for Weight Loss in Adults With Type 2 Diabetes Mellitus: A Meta-analysis Arch Intern Med, July 12, 2004; 164(13): 1395 - 1404. [Abstract] [Full Text] [PDF]

				G. Di Sacco Amfepramone does not cause primary pulmonary hypertension Eur. Respir. J., May 1, 2004; 23(5): 790 - 790. [Full Text] [PDF]

				D. E. Kelley, L. H. Kuller, T. M. McKolanis, P. Harper, J. Mancino, and S. Kalhan Effects of Moderate Weight Loss and Orlistat on Insulin Resistance, Regional Adiposity, and Fatty Acids in Type 2 Diabetes Diabetes Care, January 1, 2004; 27(1): 33 - 40. [Abstract] [Full Text] [PDF]

				J. W. Anderson, C. W.C. Kendall, and D. J.A. Jenkins Importance of Weight Management in Type 2 Diabetes: Review with Meta-analysis of Clinical Studies J. Am. Coll. Nutr., October 1, 2003; 22(5): 331 - 339. [Abstract] [Full Text] [PDF]

				B. O. Ogunnaike, S. B. Jones, D. B. Jones, D. Provost, and C. W. Whitten Anesthetic Considerations for Bariatric Surgery Anesth. Analg., December 1, 2002; 95(6): 1793 - 1805. [Full Text] [PDF]

				G. A. Bray The Underlying Basis for Obesity: Relationship to Cancer J. Nutr., November 1, 2002; 132(11): 3451S - 3455. [Abstract] [Full Text] [PDF]

				M. Steelman, W. P. Weiss, F. Maese, M. Lechin, S. Z. Yanovski, and J. A. Yanovski Pharmacotherapy for Obesity N. Engl. J. Med., June 27, 2002; 346(26): 2092 - 2093. [Full Text] [PDF]

				A. Del Parigi, K. Chen, J.-F. Gautier, A. D Salbe, R. E Pratley, E. Ravussin, E. M Reiman, and P A. Tataranni Sex differences in the human brain's response to hunger and satiation Am. J. Clinical Nutrition, June 1, 2002; 75(6): 1017 - 1022. [Abstract] [Full Text] [PDF]

				S. Z. Yanovski and J. A. Yanovski Obesity N. Engl. J. Med., February 21, 2002; 346(8): 591 - 602. [Full Text] [PDF]

				G. J. Hom, M. J. Forrest, T. J. Bach, E. Brady, M. R. Candelore, M. A. Cascieri, D. J. Fletcher, M. H. Fisher, S. A. Iliff, R. Mathvink, et al. {beta}3-Adrenoceptor Agonist-Induced Increases in Lipolysis, Metabolic Rate, Facial Flushing, and Reflex Tachycardia in Anesthetized Rhesus Monkeys J. Pharmacol. Exp. Ther., April 1, 2001; 297(1): 299 - 307. [Abstract] [Full Text]

				C. V. Mobbs, G. A. Bray, R. L. Atkinson, A. Bartke, C. E. Finch, E. Maratos-Flier, J. N. Crawley, and J. F. Nelson Neuroendocrine and Pharmacological Manipulations to Assess How Caloric Restriction Increases Life Span J Gerontol A Biol Sci Med Sci, March 1, 2001; 56(suppl_1): 34 - 44. [Abstract] [Full Text] [PDF]

				T. A. Wadden, R. I. Berkowitz, D. B. Sarwer, R. Prus-Wisniewski, and C. Steinberg Benefits of Lifestyle Modification in the Pharmacologic Treatment of Obesity: A Randomized Trial Arch Intern Med, January 22, 2001; 161(2): 218 - 227. [Abstract] [Full Text] [PDF]

				A. INUI Transgenic study of energy homeostasis equation: implications and confounding influences FASEB J, November 1, 2000; 14(14): 2158 - 2170. [Abstract] [Full Text]