The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily1
Vivian Hwa,
Youngman Oh and
Ron G. Rosenfeld
Department of Pediatrics, Oregon Health Sciences University,
Portland, Oregon 97201
I. Introduction
A. Concept of an IGFBP superfamily
B. Superfamilynomenclature
II. IGFBP Family
A. Structure of IGFBPs
B.Correlations between structure and function
C. Biologicalfunctions of IGFBPs
D. Genomics of IGFBPs
III. Mac25
A.IGFBP-rP1 (Mac25/TAF/PSF)
IV. CCN Family
A. IGFBP-rP2 (CTGF)
B. IGFBP-rP3 (NovH)
C. IGFBP-rP4 (Cyr61)
D. New members
V. L56
A. IGFBP-rP5 (L56/HtrA)
VI. ESM-1
A. IGFBP-rP6(endothelial specific molecule-1)
VII. Structural RelationshipsWithin the IGFBP Superfamily
A. Protein domains (modules)
B. Gene structure and correlation with protein domains
VIII.Functional Relationships Within the IGFBP Superfamily
A. IGFbinding
B. Insulin binding
C. IGF/insulin-independent actions
IX. Evolutionary Relationships Within the IGFBP Superfamily
A. N-terminal domains
B. C-terminal domains
C. Evolutionarymodels
X. Summary
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R. D. Devlin, Z. Du, V. Buccilli, V. Jorgetti, and E. Canalis Transgenic Mice Overexpressing Insulin-Like Growth Factor Binding Protein-5 Display Transiently Decreased Osteoblastic Function and Osteopenia
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A. Bachelot, P. Monget, P. Imbert-Bollore, K. Coshigano, J. J. Kopchick, P. A. Kelly, and N. Binart Growth Hormone Is Required for Ovarian Follicular Growth
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E. J. Kim, P. E. Holthuizen, H. S. Park, Y. L. Ha, K. C. Jung, and J. H. Y. Park Trans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth
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T. J. Maures and C. Duan Structure, Developmental Expression, and Physiological Regulation of Zebrafish IGF Binding Protein-1
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H.-M. P. Wilson, R. S. Birnbaum, M. Poot, L. S. Quinn, and K. Swisshelm Insulin-like Growth Factor Binding Protein-related Protein 1 Inhibits Proliferation of MCF-7 Breast Cancer Cells via a Senescence-like Mechanism
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A. Hourvitz, A. Kuwahara, J. D. Hennebold, A. B. Tavares, H. Negishi, T. H. Lee, G. F. Erickson, and E. Y. Adashi The Regulated Expression of the Pregnancy-Associated Plasma Protein-A in the Rodent Ovary: A Proposed Role in the Development of Dominant Follicles and of Corpora Lutea
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J. Liu, V.-M. Kosma, T. Vanttinen, C. Hyden-Granskog, and R. Voutilainen Gonadotrophins inhibit the expression of insulin-like growth factor binding protein-related protein-2 mRNA in cultured human granulosa-luteal cells
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P Vorwerk, H Wex, B Hohmann, K Mohnike, U Schmidt, and U Mittler Expression of components of the IGF signalling system in childhood acute lymphoblastic leukaemia
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C. H. Lang, G. J. Nystrom, and R. A. Frost Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent
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Y. Lu, X. Zi, Y. Zhao, D. Mascarenhas, and M. Pollak Insulin-Like Growth Factor-I Receptor Signaling and Resistance to Trastuzumab (Herceptin)
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A. Hoeflich, R. Reisinger, H. Lahm, W. Kiess, W. F. Blum, H. J. Kolb, M. M. Weber, and E. Wolf Insulin-like Growth Factor-binding Protein 2 in Tumorigenesis: Protector or Promoter?
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C. G. Goodyer, R. M. O. Figueiredo, S. Krackovitch, L. De Souza Li, J. A. Manalo, and G. Zogopoulos Characterization of the growth hormone receptor in human dermal fibroblasts and liver during development
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A. Decensi, H. Johansson, R. Miceli, L. Mariani, T. Camerini, E. Cavadini, M. G. Di Mauro, A. Barreca, A. G. Gonzaga, S. Diani, et al. Long-Term Effects of Fenretinide, a Retinoic Acid Derivative, on the Insulin-like Growth Factor System in Women with Early Breast Cancer
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M. W. Elmlinger, I. Mayer, D. Schnabel, B. S. Schuett, D. Diesing, G. Romalo, H. A. Wollmann, W. Weidemann, K.-D. Spindler, M. B. Ranke, et al. Decreased Expression of IGF-II and Its Binding Protein, IGF-Binding Protein-2, in Genital Skin Fibroblasts of Patients with Complete Androgen Insensitivity Syndrome Compared with Normally Virilized Males
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C. K. Buckway, E. M. Wilson, M. Ahlsen, P. Bang, Y. Oh, and R. G. Rosenfeld Mutation of Three Critical Amino Acids of the N-Terminal Domain of IGF-Binding Protein-3 Essential for High Affinity IGF Binding
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Z Laron Insulin-like growth factor 1 (IGF-1): a growth hormone
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P Vilmos, K Gaudenz, Z Hegedus, and J L Marsh The Twisted gastrulation family of proteins, together with the IGFBP and CCN families, comprise the TIC superfamily of cysteine rich secreted factors
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E. M. Wilson, Y. Oh, V. Hwa, and R. G. Rosenfeld Interaction of IGF-Binding Protein-Related Protein 1 with a Novel Protein, Neuroendocrine Differentiation Factor, Results in Neuroendocrine Differentiation of Prostate Cancer Cells
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T. C. Voss, M. P. Flynn, and D. L. Hurley IGF-I Causes an Ultrasensitive Reduction in GH mRNA Levels via an Extracellular Mechanism Involving IGF Binding Proteins
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C. Martinerie, C. Gicquel, A. Louvel, M. Laurent, P. N. Schofield, and Y. Le Bouc Altered Expression of novH Is Associated with Human Adrenocortical Tumorigenesis
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T. Nickerson, F. Chang, D. Lorimer, S. P. Smeekens, C. L. Sawyers, and M. Pollak In Vivo Progression of LAPC-9 and LNCaP Prostate Cancer Models to Androgen Independence Is Associated with Increased Expression of Insulin-like Growth Factor I (IGF-I) and IGF-I Receptor (IGF-IR)
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K. Prelle, M. Stojkovic, K. Boxhammer, J. Motlik, D. Ewald, G. J. Arnold, and E. Wolf Insulin-Like Growth Factor I (IGF-I) and Long R3IGF-I Differently Affect Development and Messenger Ribonucleic Acid Abundance for IGF-Binding Proteins and Type I IGF Receptors in in Vitro Produced Bovine Embryos
Endocrinology,
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R. G. Rosenfeld, V. Hwa, and Y. Oh Nomenclature of the Insulin-Like Growth Factor-Binding Protein Superfamily
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