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Endocrine Reviews 20 (6): 761-787
Copyright © 1999 by The Endocrine Society

The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily1

Vivian Hwa, Youngman Oh and Ron G. Rosenfeld

Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201

I. Introduction
A. Concept of an IGFBP superfamily
B. Superfamily nomenclature
II. IGFBP Family
A. Structure of IGFBPs
B. Correlations between structure and function
C. Biological functions of IGFBPs
D. Genomics of IGFBPs
III. Mac25
A. IGFBP-rP1 (Mac25/TAF/PSF)
IV. CCN Family
A. IGFBP-rP2 (CTGF)
B. IGFBP-rP3 (NovH)
C. IGFBP-rP4 (Cyr61)
D. New members
V. L56
A. IGFBP-rP5 (L56/HtrA)
VI. ESM-1
A. IGFBP-rP6 (endothelial specific molecule-1)
VII. Structural Relationships Within the IGFBP Superfamily
A. Protein domains (modules)
B. Gene structure and correlation with protein domains
VIII. Functional Relationships Within the IGFBP Superfamily
A. IGF binding
B. Insulin binding
C. IGF/insulin-independent actions
IX. Evolutionary Relationships Within the IGFBP Superfamily
A. N-terminal domains
B. C-terminal domains
C. Evolutionary models
X. Summary




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