Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism1
Béatrice Desvergne and
Walter Wahli
Institute of Animal Biology, University of Lausanne, CH-1015
Lausanne, Switzerland
I. Introduction
II. Molecular Aspects
A. PPAR isotypes:identity, genomic organization and chromosomal
localization
B. DNA binding properties
C. PPAR ligand-binding properties
D. Alternative pathways for PPAR activation
E. PPAR-mediatedtransactivation properties
III. Physiological Aspects
A.Differential expression of PPAR mRNAs
B. PPAR target genesand functions in fatty acid metabolism
C. PPARs and controlof inflammatory responses
D. PPARs and atherosclerosis
E.PPARs and the development of the fetal epidermal permeabilitybarrier
F. PPARs, carcinogenesis, and control of the cellcycle
IV. Conclusions
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B. D. Abbott, C. J. Wolf, J. E. Schmid, K. P. Das, R. D. Zehr, L. Helfant, S. Nakayama, A. B. Lindstrom, M. J. Strynar, and C. Lau Perfluorooctanoic Acid Induced Developmental Toxicity in the Mouse is Dependent on Expression of Peroxisome Proliferator Activated Receptor-alpha
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M. Takeda, F. Otsuka, H. Otani, K. Inagaki, T. Miyoshi, J. Suzuki, Y. Mimura, T. Ogura, and H. Makino Effects of peroxisome proliferator-activated receptor activation on gonadotropin transcription and cell mitosis induced by bone morphogenetic proteins in mouse gonadotrope L{beta}T2 cells
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A. Guellich, T. Damy, Y. Lecarpentier, M. Conti, V. Claes, J.-L. Samuel, J. Quillard, J.-L. Hebert, T. Pineau, and C. Coirault Role of oxidative stress in cardiac dysfunction of PPAR{alpha}-/- mice
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W.-L. Chou, L.-M. Chuang, C.-C. Chou, A. H.-J. Wang, J. A. Lawson, G. A. FitzGerald, and Z.-F. Chang Identification of a Novel Prostaglandin Reductase Reveals the Involvement of Prostaglandin E2 Catabolism in Regulation of Peroxisome Proliferator-activated Receptor {gamma} Activation
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N. Viswakarma, S. Yu, S. Naik, P. Kashireddy, K. Matsumoto, J. Sarkar, S. Surapureddi, Y. Jia, M. S. Rao, and J. K. Reddy Transcriptional Regulation of Cidea, Mitochondrial Cell Death-inducing DNA Fragmentation Factor {alpha}-Like Effector A, in Mouse Liver by Peroxisome Proliferator-activated Receptor {alpha} and {gamma}
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P. D. Cornwell and R. G. Ulrich Investigating the Mechanistic Basis for Hepatic Toxicity Induced by an Experimental Chemokine Receptor 5 (CCR5) Antagonist Using a Compendium of Gene Expression Profiles
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F. Zapata-Gonzalez, F. Rueda, J. Petriz, P. Domingo, F. Villarroya, A. de Madariaga, and J. C. Domingo 9-cis-Retinoic Acid (9cRA), a Retinoid X Receptor (RXR) Ligand, Exerts Immunosuppressive Effects on Dendritic Cells by RXR-Dependent Activation: Inhibition of Peroxisome Proliferator-Activated Receptor {gamma} Blocks Some of the 9cRA Activities, and Precludes Them to Mature Phenotype Development
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S. Chintharlapalli, S. Papineni, I. Jutooru, A. McAlees, and S. Safe Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells
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D. Genini and C. V. Catapano Block of Nuclear Receptor Ubiquitination: A MECHANISM OF LIGAND-DEPENDENT CONTROL OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR {delta} ACTIVITY
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A. Gatica, M. C. Aguilera, D. Contador, G. Loyola, C. O. Pinto, L. Amigo, J. E. Tichauer, S. Zanlungo, and M. Bronfman P450 CYP2C epoxygenase and CYP4A {omega}-hydroxylase mediate ciprofibrate-induced PPAR{alpha}-dependent peroxisomal proliferation
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L. Michalik, V. Zoete, G. Krey, A. Grosdidier, L. Gelman, P. Chodanowski, J. N. Feige, B. Desvergne, W. Wahli, and O. Michielin Combined Simulation and Mutagenesis Analyses Reveal the Involvement of Key Residues for Peroxisome Proliferator-activated Receptor{alpha} Helix 12 Dynamic Behavior
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