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Endocrine Reviews 20 (3): 418-434
Copyright © 1999 by The Endocrine Society

Selective Estrogen Receptor Modulators: Clinical Spectrum1

Felicia Cosman and Robert Lindsay

Clinical Research and Regional Bone Centers, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York 10993

I. Introduction
II. Breast Effects
A. Women with primary breast cancer without metastases
B. Women with metastatic disease
C. Breast cancer prevention
III. Reproductive System Effects
A. Ovary
B. Uterus
C. Vagina
D. Neuroendocrine
IV. Skeletal Effects: Bone Mass, Bone Metabolism, and Fracture Occurrence
A. Tamoxifen
B. Raloxifene
V. Vascular System Effects: Intermediate Markers and Disease Outcomes
A. Intermediate markers
B. Vascular disease outcomes
VI. Central Nervous System Effects
A. Cognitive function and mood
B. Eye disease
VII. Hepatic Effects
VIII. Miscellaneous Effects
IX. Conclusion




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