Clinical Research and Regional Bone Centers, Helen Hayes Hospital,
New York State Department of Health, West Haverstraw, New York
10993
I. Introduction
II. Breast Effects
A. Women with primarybreast cancer without metastases
B. Women with metastaticdisease
C. Breast cancer prevention
III. Reproductive SystemEffects
A. Ovary
B. Uterus
C. Vagina
D. Neuroendocrine
IV. Skeletal Effects: Bone Mass, Bone Metabolism, and FractureOccurrence
A. Tamoxifen
B. Raloxifene
V. Vascular SystemEffects: Intermediate Markers and DiseaseOutcomes
A. Intermediatemarkers
B. Vascular disease outcomes
VI. Central NervousSystem Effects
A. Cognitive function and mood
B. Eye disease
VII. Hepatic Effects
VIII. Miscellaneous Effects
IX. Conclusion
This article has been cited by other articles:
F. Saad, J. D. Adachi, J. P. Brown, L. A. Canning, K. A. Gelmon, R. G. Josse, and K. I. Pritchard Cancer Treatment-Induced Bone Loss in Breast and Prostate Cancer
J. Clin. Oncol.,
November 20, 2008;
26(33):
5465 - 5476.
[Abstract][Full Text][PDF]
C. Prakash, K. A. Johnson, C. M. Schroeder, and M. J. Potchoiba Metabolism, Distribution, and Excretion of a Next Generation Selective Estrogen Receptor Modulator, Lasofoxifene, in Rats and Monkeys
Drug Metab. Dispos.,
September 1, 2008;
36(9):
1753 - 1769.
[Abstract][Full Text][PDF]
G. Coiret, A.-S. Borowiec, P. Mariot, H. Ouadid-Ahidouch, and F. Matifat The Antiestrogen Tamoxifen Activates BK Channels and Stimulates Proliferation of MCF-7 Breast Cancer Cells
Mol. Pharmacol.,
March 1, 2007;
71(3):
843 - 851.
[Abstract][Full Text][PDF]
M Maggiolini, A G Recchia, D Bonofiglio, S Catalano, A Vivacqua, A Carpino, V Rago, R Rossi, and S Ando The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor {alpha} in human breast cancer cells
J. Mol. Endocrinol.,
October 1, 2005;
35(2):
269 - 281.
[Abstract][Full Text][PDF]
C. J. Larson, D. L. Osburn, K. Schmitz, L. Giampa, S.-M. Mong, K. Marschke, H. M. Seidel, J. Rosen, and A. Negro-Vilar Peptide Binding Identifies an ER{alpha} Conformation That Generates Selective Activity in Multiple In Vitro Assays
J Biomol Screen,
September 1, 2005;
10(6):
590 - 598.
[Abstract][PDF]
T. Takahashi, M. Ohmichi, J. Kawagoe, C. Ohshima, M. Doshida, T. Ohta, M. Saitoh, A. Mori-Abe, B. Du, H. Igarashi, et al. Growth Factors Change Nuclear Distribution of Estrogen Receptor-{alpha} via Mitogen-Activated Protein Kinase or Phosphatidylinositol 3-Kinase Cascade in a Human Breast Cancer Cell Line
Endocrinology,
September 1, 2005;
146(9):
4082 - 4089.
[Abstract][Full Text][PDF]
J. E Sanchez-Criado, C. Bellido, R. Aguilar, and J. C Garrido-Gracia A paradoxical inhibitory effect of oestradiol-17{beta} on GnRH self-priming in pituitaries from tamoxifen-treated rats
J. Endocrinol.,
July 1, 2005;
186(1):
43 - 49.
[Abstract][Full Text][PDF]
A. Tamrazi, K. E. Carlson, A. L. Rodriguez, and J. A. Katzenellenbogen Coactivator Proteins as Determinants of Estrogen Receptor Structure and Function: Spectroscopic Evidence for a Novel Coactivator-Stabilized Receptor Conformation
Mol. Endocrinol.,
June 1, 2005;
19(6):
1516 - 1528.
[Abstract][Full Text][PDF]
J. Gauduchon, F. Gouilleux, S. Maillard, V. Marsaud, J.-M. Renoir, and B. Sola 4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members
Clin. Cancer Res.,
March 15, 2005;
11(6):
2345 - 2354.
[Abstract][Full Text][PDF]
J E Sanchez-Criado, J M. de las Mulas, C Bellido, R Aguilar, and J C Garrido-Gracia Gonadotrope oestrogen receptor-{alpha} and -{beta} and progesterone receptor immunoreactivity after ovariectomy and exposure to oestradiol benzoate, tamoxifen or raloxifene in the rat: correlation with LH secretion
J. Endocrinol.,
January 1, 2005;
184(1):
59 - 68.
[Abstract][Full Text][PDF]
R. F. Casper Phytoestrogens, Clomiphene, and the Uterus
Reproductive Sciences,
July 1, 2004;
11(5):
261 - 262.
[PDF]
M. Tena-Sempere, V.M. Navarro, A. Mayen, C. Bellido, and J.E. Sanchez-Criado Regulation of Estrogen Receptor (ER) Isoform Messenger RNA Expression by Different ER Ligands in Female Rat Pituitary
Biol Reprod,
March 1, 2004;
70(3):
671 - 678.
[Abstract][Full Text][PDF]
A. Tamrazi, K. E. Carlson, and J. A. Katzenellenbogen Molecular Sensors of Estrogen Receptor Conformations and Dynamics
Mol. Endocrinol.,
December 1, 2003;
17(12):
2593 - 2602.
[Abstract][Full Text][PDF]
M. Dutertre and C. L. Smith Ligand-Independent Interactions of p160/Steroid Receptor Coactivators and CREB-Binding Protein (CBP) with Estrogen Receptor-{alpha}: Regulation by Phosphorylation Sites in the A/B Region Depends on Other Receptor Domains
Mol. Endocrinol.,
July 1, 2003;
17(7):
1296 - 1314.
[Abstract][Full Text][PDF]
A. Cagnacci, A. M. Paoletti, A. Zanni, S. Arangino, G. Ibba, M. Orru, G. B. Melis, and A. Volpe Raloxifene Does Not Modify Insulin Sensitivity and Glucose Metabolism in Postmenopausal Women
J. Clin. Endocrinol. Metab.,
September 1, 2002;
87(9):
4117 - 4121.
[Abstract][Full Text][PDF]
T. Simoncini, G. Varone, L. Fornari, P. Mannella, M. Luisi, F. Labrie, and A. R. Genazzani Genomic and Nongenomic Mechanisms of Nitric Oxide Synthesis Induction in Human Endothelial Cells by a Fourth-Generation Selective Estrogen Receptor Modulator
Endocrinology,
June 1, 2002;
143(6):
2052 - 2061.
[Abstract][Full Text][PDF]
H. Brady, S. Desai, L. M. Gayo-Fung, S. Khammungkhune, J. A. McKie, E. O'Leary, L. Pascasio, M. K. Sutherland, D. W. Anderson, S. S. Bhagwat, et al. Effects of SP500263, a Novel, Potent Antiestrogen, on Breast Cancer Cells and in Xenograft Models
Cancer Res.,
March 1, 2002;
62(5):
1439 - 1442.
[Abstract][Full Text][PDF]
T. S Mikkola and T. B Clarkson Estrogen replacement therapy, atherosclerosis, and vascular function
Cardiovasc Res,
February 15, 2002;
53(3):
605 - 619.
[Abstract][Full Text][PDF]
J. M. Fitts, R. M. Klein, and C. A. Powers Estrogen and Tamoxifen Interplay with T3 in Male Rats: Pharmacologically Distinct Classes of Estrogen Responses Affecting Growth, Bone, and Lipid Metabolism, and Their Relation to Serum GH and IGF-I
Endocrinology,
October 1, 2001;
142(10):
4223 - 4235.
[Abstract][Full Text][PDF]
S. Nilsson, S. Makela, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, K. Pettersson, M. Warner, and J.-A. Gustafsson Mechanisms of Estrogen Action
Physiol Rev,
October 1, 2001;
81(4):
1535 - 1565.
[Abstract][Full Text][PDF]
B. H. Arjmandi The Role of Phytoestrogens in the Prevention and Treatment of Osteoporosis in Ovarian Hormone Deficiency
J. Am. Coll. Nutr.,
October 1, 2001;
20(90005):
398S - 402.
[Abstract][Full Text]
M. Dutertre and C. L. Smith Molecular Mechanisms of Selective Estrogen Receptor Modulator (SERM) Action
J. Pharmacol. Exp. Ther.,
November 1, 2000;
295(2):
431 - 437.
[Abstract][Full Text]
D. M. Kraichely, J. Sun, J. A. Katzenellenbogen, and B. S. Katzenellenbogen Conformational Changes and Coactivator Recruitment by Novel Ligands for Estrogen Receptor-{alpha} and Estrogen Receptor-{beta}: Correlations with Biological Character and Distinct Differences among SRC Coactivator Family Members
Endocrinology,
October 1, 2000;
141(10):
3534 - 3545.
[Abstract][Full Text][PDF]
S. Tamir, M. Eizenberg, D. Somjen, N. Stern, R. Shelach, A. Kaye, and J. Vaya Estrogenic and Antiproliferative Properties of Glabridin from Licorice in Human Breast Cancer Cells
Cancer Res.,
October 1, 2000;
60(20):
5704 - 5709.
[Abstract][Full Text]
R. B. Dickson and G. M. Stancel Chapter 8: Estrogen Receptor-Mediated Processes in Normal and Cancer Cells
J Natl Cancer Inst Monographs,
July 1, 2000;
2000(27):
135 - 145.
[Abstract][Full Text][PDF]
H. Z. Ke, H. Qi, D. T. Crawford, K. L. Chidsey-Frink, H. A. Simmons, and D. D. Thompson Lasofoxifene (CP-336,156), a Selective Estrogen Receptor Modulator, Prevents Bone Loss Induced by Aging and Orchidectomy in the Adult Rat
Endocrinology,
April 1, 2000;
141(4):
1338 - 1344.
[Abstract][Full Text][PDF]
A. Negro-Vilar Selective Androgen Receptor Modulators (SARMs): A Novel Approach to Androgen Therapy for the New Millennium
J. Clin. Endocrinol. Metab.,
October 1, 1999;
84(10):
3459 - 3462.
[Full Text][PDF]
N. K. Shevde, A. C. Bendixen, K. M. Dienger, and J. W. Pike Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression
PNAS,
July 5, 2000;
97(14):
7829 - 7834.
[Abstract][Full Text][PDF]
