Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families
Tatsuo Suda,
Naoyuki Takahashi,
Nobuyuki Udagawa,
Eijiro Jimi,
Matthew T. Gillespie and
T. John Martin
Department of Biochemistry (T.S., N.T., N.U., E.J.), School of
Dentistry, Showa University, Shinagawa-ku, Tokyo 142-8555,
Japan; and St. Vincent’s Institute of Medical Research (M.T.G.,
T.J.M.), University of Melbourne, Fitzroy, Victoria 3065,
Australia
I. Introduction
II. Role of Osteoblasts/Stromal Cells in OsteoclastDifferentiationand
Function
A. Origin of osteoclasts
B.Stimulation of osteoclast differentiation by osteoblasts/stromalcells
C. Stimulation of osteoclast function by osteoblasts/stromalcells
III. New Members of the Tumor Necrosis Factor (TNF)Receptorand Ligand
Families
A. Osteoprotegerin (OPG)
B.Osteoclast differentiation factor (ODF) and stromal osteoclast-forming
activity(SOFA)
IV. Regulatory Mechanism in Osteoclast Developmentand Function
A. Regulatory mechanism of osteoclast differentiationby RANKL
B. Regulatory mechanism of RANKL action on osteoclastfunction
C. Signals induced by interleukin-1 (IL-1) and RANKLin osteoclasts
V. Regulation of Human Osteoclast Development
VI. Summary and Conclusion
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[Abstract][Full Text][PDF]
W. Gianni, A. Ricci, P. Gazzaniga, M. Brama, M. Pietropaolo, S. Votano, F. Patane, A. M. Agliano, G. Spera, V. Marigliano, et al. Raloxifene Modulates Interleukin-6 and Tumor Necrosis Factor-{alpha} Synthesis in Vivo: Results from a Pilot Clinical Study
J. Clin. Endocrinol. Metab.,
December 1, 2004;
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[Abstract][Full Text][PDF]
M. Matsumoto, M. Kogawa, S. Wada, H. Takayanagi, M. Tsujimoto, S. Katayama, K. Hisatake, and Y. Nogi Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1
J. Biol. Chem.,
October 29, 2004;
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T. Kukita, N. Wada, A. Kukita, T. Kakimoto, F. Sandra, K. Toh, K. Nagata, T. Iijima, M. Horiuchi, H. Matsusaki, et al. RANKL-induced DC-STAMP Is Essential for Osteoclastogenesis
J. Exp. Med.,
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N. Sato, N. Takahashi, K. Suda, M. Nakamura, M. Yamaki, T. Ninomiya, Y. Kobayashi, H. Takada, K. Shibata, M. Yamamoto, et al. MyD88 But Not TRIF Is Essential for Osteoclastogenesis Induced by Lipopolysaccharide, Diacyl Lipopeptide, and IL-1{alpha}
J. Exp. Med.,
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[Abstract][Full Text][PDF]
D. Kamei, K. Yamakawa, Y. Takegoshi, M. Mikami-Nakanishi, Y. Nakatani, S. Oh-ishi, H. Yasui, Y. Azuma, N. Hirasawa, K. Ohuchi, et al. Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1
J. Biol. Chem.,
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T. M. Doherty, L. A. Fitzpatrick, D. Inoue, J.-H. Qiao, M. C. Fishbein, R. C. Detrano, P. K. Shah, and T. B. Rajavashisth Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification
Endocr. Rev.,
August 1, 2004;
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Y. Okamatsu, D. Kim, R. Battaglino, H. Sasaki, U. Spate, and P. Stashenko MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival.
J. Immunol.,
August 1, 2004;
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M. Bastepe, A. Raas-Rothschild, J. Silver, I. Weissman, S. Wientroub, H. Juppner, and D. Gillis A Form of Jansen's Metaphyseal Chondrodysplasia with Limited Metabolic and Skeletal Abnormalities Is Caused by a Novel Activating Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mutation
J. Clin. Endocrinol. Metab.,
July 1, 2004;
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S. Ishikawa, N. Arase, T. Suenaga, Y. Saita, M. Noda, T. Kuriyama, H. Arase, and T. Saito Involvement of FcR{gamma} in signal transduction of osteoclast-associated receptor (OSCAR)
Int. Immunol.,
July 1, 2004;
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D. Vanderschueren, L. Vandenput, S. Boonen, M. K. Lindberg, R. Bouillon, and C. Ohlsson Androgens and Bone
Endocr. Rev.,
June 1, 2004;
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K. Saito, N. Ohara, H. Hotokezaka, S. Fukumoto, K. Yuasa, M. Naito, T. Fujiwara, and K. Nakayama Infection-induced Up-regulation of the Costimulatory Molecule 4-1BB in Osteoblastic Cells and Its Inhibitory Effect on M-CSF/RANKL-induced in Vitro Osteoclastogenesis
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J. L. Roccisana, N. Kawanabe, H. Kajiya, M. Koide, G. D. Roodman, and S. V. Reddy Functional Role for Heat Shock Factors in the Transcriptional Regulation of Human RANK Ligand Gene Expression in Stromal/Osteoblast Cells
J. Biol. Chem.,
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N. Okahashi, H. Inaba, I. Nakagawa, T. Yamamura, M. Kuboniwa, K. Nakayama, S. Hamada, and A. Amano Porphyromonas gingivalis Induces Receptor Activator of NF-{kappa}B Ligand Expression in Osteoblasts through the Activator Protein 1 Pathway
Infect. Immun.,
March 1, 2004;
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H.-I. Shin, P. Divieti, N. A. Sims, T. Kobayashi, D. Miao, A. C. Karaplis, R. Baron, R. Bringhurst, and H. M. Kronenberg gp130-Mediated Signaling Is Necessary for Normal Osteoblastic Function in Vivo and in Vitro
Endocrinology,
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A. Matsunuma, T. Kawane, T. Maeda, S. Hamada, and N. Horiuchi Leptin Corrects Increased Gene Expression of Renal 25-Hydroxyvitamin D3-1{alpha}-Hydroxylase and -24-Hydroxylase in Leptin-Deficient, ob/ob Mice
Endocrinology,
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K. Suda, N. Udagawa, N. Sato, M. Takami, K. Itoh, J.-T. Woo, N. Takahashi, and K. Nagai Suppression of Osteoprotegerin Expression by Prostaglandin E2 Is Crucially Involved in Lipopolysaccharide-Induced Osteoclast Formation
J. Immunol.,
February 15, 2004;
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S. Niida, M. Kawahara, Y. Ishizuka, Y. Ikeda, T. Kondo, T. Hibi, Y. Suzuki, K. Ikeda, and N. Taniguchi {gamma}-Glutamyltranspeptidase Stimulates Receptor Activator of Nuclear Factor-{kappa}B Ligand Expression Independent of Its Enzymatic Activity and Serves as a Pathological Bone-resorbing Factor
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February 13, 2004;
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E. Tian, F. Zhan, R. Walker, E. Rasmussen, Y. Ma, B. Barlogie, and J. D. Shaughnessy Jr. The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
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D.-H. Chung, M. B. Humphrey, M. C. Nakamura, D. G. Ginzinger, W. E. Seaman, and M. R. Daws CMRF-35-Like Molecule-1, a Novel Mouse Myeloid Receptor, Can Inhibit Osteoclast Formation
J. Immunol.,
December 15, 2003;
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G. Thomas, P. Moffatt, P. Salois, M.-H. Gaumond, R. Gingras, E. Godin, D. Miao, D. Goltzman, and C. Lanctot Osteocrin, a Novel Bone-specific Secreted Protein That Modulates the Osteoblast Phenotype
J. Biol. Chem.,
December 12, 2003;
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M. Nakamura, N. Udagawa, S. Matsuura, M. Mogi, H. Nakamura, H. Horiuchi, N. Saito, B. Y. Hiraoka, Y. Kobayashi, K. Takaoka, et al. Osteoprotegerin Regulates Bone Formation through a Coupling Mechanism with Bone Resorption
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A. Takuma, T. Kaneda, T. Sato, S. Ninomiya, M. Kumegawa, and Y. Hakeda Dexamethasone Enhances Osteoclast Formation Synergistically with Transforming Growth Factor-{beta} by Stimulating the Priming of Osteoclast Progenitors for Differentiation into Osteoclasts
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[Abstract][Full Text][PDF]
