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Endocrine Reviews 20 (3): 321-344
Copyright © 1999 by The Endocrine Society

Nuclear Receptor Coregulators: Cellular and Molecular Biology1

Neil J. McKenna, Rainer B. Lanz and Bert W. O’Malley

Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030

I. Introduction
A. The nuclear receptor superfamily
B. General transcription factors (GTFs)
II. Nuclear Receptor Coactivators
A. Background
B. Receptor-associated proteins and coactivators
III. Nuclear Receptor Corepressors
A. Background
B. Corepressors
IV. Nuclear Receptors and Chromatin
A. Background
B. The MMTV and TRßA promoters
C. Coactivators and acetylation
D. Chromatin-remodeling proteins
E. Corepressors and deacetylation
V. Concluding Remarks




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